IP Library › Granted Patent US 11,590,231
Granted Patent B2
US 11,590,231 · App. 16/632,626 · Granted Feb 28, 2023

Compositions for enhancing bioavailability of pharmaceuticals, supplements and ingested substances

Inventors: Andrew R. Lefkowitz (Solon, OH); Sean Farmer (North Miami Beach, FL); Ken Alibek (Solon, OH)
Assignee: LOCUS SOLUTIONS IPCO, LLC
A61K47/26A61K9/5123A61K47/42
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Quick Facts
Patent No.
US 11,590,231
App. No.
16/632,626
Filed
Jan 21, 2020
Granted
Feb 28, 2023
Kind
B2
Art Unit
1615
USPC
424/451
Abstract

The present invention relates to compositions and methods for enhancing bioavailability of health-promoting substances, such as pharmaceuticals and nutritional supplements. The subject invention utilizes an adjuvant composition comprising one or more microbial-produced biosurfactants and/or isoforms thereof, to enhance bioavailability of health-promoting substances and to reduce the effective dosage that is required.

Claims (4)

1. A method for enhancing the bioavailability of a pharmaceutical, the method comprising orally administering to a subject, a composition comprising said pharmaceutical and a bioavailability-enhancing amount of a purified sophorolipid, wherein at least 90% by weight of said purified sophorolipid is in a lactonic form, and

wherein said pharmaceutical is at least one of antivirals, pain-relievers, and anti-inflammatory compounds.

2. The adjuvant composition of claim 1 , wherein said pharmaceutical is acyclovir, ribavirin, valacyclovir, or famciclovir.

3. The adjuvant composition of claim 1 , wherein said pharmaceutical is ibuprofen or aspirin.

Assignments (9)
RELEASE OF SECURITY INTEREST Recorded Nov 18, 2024
From: U.S. BANK TRUST COMPANY
To: LOCUS SOLUTIONS, LLC; LOCUS MANAGEMENT GP, INC.; LOCUS MANAGEMENT, LLC; LOCUS IP COMPANY, LLC; LOCUS OIL HOLDING, LLC,; LOCUS BIO-ENERGY SOLUTIONS, LLC; LOCUS OIL IP COMPANY, LLC; LOCUS AGRICULTURE HOLDING, LLC; LOCUS AGRICULTURAL SOLUTIONS, LLC; LOCUS AGRICULTURE IP COMPANY, LLC,; LOCUS SOLUTIONS IPCO, LLC; LOCUS SOLUTIONS IPHOLDCO, LLC; LOCUS CONSUMER BRANDS HOLDING, LLC; ARCTIVA WELLNESS, LLC
Reel/Frame 069386/0272 →
SECURITY INTEREST Recorded Nov 11, 2024
From: LOCUS SOLUTIONS IPCO, LLC
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 069333/0911 →
RELEASE OF SECURITY INTEREST Recorded Oct 30, 2024
From: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: LOCUS SOLUTIONS IPCO, LLC
Reel/Frame 069273/0361 →
SECURITY INTEREST Recorded Dec 8, 2023
From: LOCUS SOLUTIONS IPCO, LLC
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS THE COLLATERAL AGENT
Reel/Frame 065836/0868 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 17, 2023
From: LOCUS IP COMPANY, LLC
To: LOCUS SOLUTIONS IPCO, LLC
Reel/Frame 065615/0905 →
SECURITY INTEREST Recorded Dec 7, 2022
From: LOCUS SOLUTIONS, LLC; LOCUS MANAGEMENT GP, INC.; LOCUS MANAGEMENT, LLC; LOCUS IP COMPANY, LLC; LOCUS OIL HOLDING, LLC; LOCUS BIO-ENERGY SOLUTIONS, LLC; LOCUS OIL IP COMPANY, LLC; LOCUS AGRICULTURE HOLDING, LLC; LOCUS AGRICULTURAL SOLUTIONS, LLC; LOCUS AGRICULTURE IP COMPANY, LLC; LOCUS SOLUTIONS IPCO, LLC; LOCUS SOLUTIONS IPHOLDCO, LLC; LOCUS CONSUMER BRANDS HOLDING, LLC; ARCTIVA WELLNESS, LLC
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 062079/0829 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 3, 2022
From: LOCUS IP COMPANY, LLC
To: LOCUS SOLUTIONS IPCO, LLC
Reel/Frame 062054/0132 →
CHANGE OF ADDRESS FOR ASSIGNEE Recorded Jan 23, 2020
From: LOCUS IP COMPANY, LLC
To: LOCUS IP COMPANY, LLC
Reel/Frame 051669/0360 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 21, 2020
From: LEFKOWITZ, ANDREW R.; FARMER, SEAN; ALIBEK, KEN; MOLDAKOZHAYEV, ALIBEK
To: LOCUS IP COMPANY, LLC
Reel/Frame 051566/0532 →