Systems and methods for detecting magnetic markers for surgical guidance
A detection system and method uses an implantable magnetic marker comprising at least one piece of a large Barkhausen jump material (LBJ). The marker is deployed to mark a tissue site in the body for subsequent surgery, and the magnetic detection system includes a handheld probe to excite the marker below the switching field for bistable switching of the marker causing a harmonic response to be generated in a sub-bistable mode that allows the marker to be detected and localised. The marker implanted may also be shorter than the critical length required to initiate bistable switching of the LBJ material.
1. A detection system for locating a marker in a body, the detection system comprising:
an implantable marker;
a drive coil arranged to excite the marker with an alternating magnetic field at a first frequency between 10 KHz and 40 KHz; and
a sense coil arranged to detect a signal received from the excited marker;
a magnetic field generator configured to drive an alternating magnetic field through the drive coil; and
a detector configured to receive the signal from the sense coil, wherein the sense coil detects a harmonic signal response from the marker at a second frequency of less than 100 KHz.
2. The detection system of claim 1 wherein the implantable marker comprises one or more pieces of magnetic material.
3. The detection system of claim 2 wherein the marker has a shape, wherein at least a portion of the shape is defined by the arrangement of the one or more pieces of magnetic material.
4. The detection system of claim 1 wherein the magnitude of the harmonic signal response from the marker when interrogated by an alternating magnetic field is the same, a maximum:minimum ratio≤4, when measured from any direction relative to the marker.
5. The detection system of claim 2 wherein the implantable marker comprises less than 5 mg of magnetic material.
6. The detection system of claim 1 wherein the marker is <25 mm in length, preferably <10 mm.
7. The detection system of claim 2 , wherein the one or more pieces of magnetic material is coated or provided within a hollow tube.
8. The detection system of claim 2 , wherein each marker is deployable from an initial, compact configuration to an extended, deployed configuration.
9. The detection system of claim 2 wherein at least one of the drive and sense coils is provided in a handheld or robotic probe.
10. The detection system of claim 2 further comprising an output module configured to process the received harmonic signal and provide at least one indicator to the user relating to a location of the marker relative to the sense coil.
11. The detection system of claim 3 , wherein the shape is a wire.
12. The detection system of claim 11 , wherein the shape comprises one or more bends.
13. The detection system of claim 11 , wherein the shape comprises three pieces of the magnetic material, wherein each of the three pieces is orthogonally arranged relative to one of the other pieces.
14. The detection system of claim 11 , wherein the shape is defined by one or more angled portions.
15. A method of locating a marker in a body, the method comprising: positioning an implantable marker near a region of interest;
exciting the marker, using a drive coil, with an alternating magnetic field at a first frequency between 10 KHz and 40 KHz;
detecting a signal received from the excited marker using a sense coil arranged relative thereto;
driving, using a magnetic field generator, an alternating magnetic field through the drive coil;
receiving the signal from the sense coil; and
detecting a harmonic signal response from the marker at a second frequency of less than 100 KHz.