Quantitative measurement of intraocular structures

1 . A method of imaging intraocular structures, comprising:

capturing, using an intraoperative optical coherence tomography (OCT) system, an OCT image of features of an eye and intraocular elements introduced to the eye;

determining geometric dimensions of the features of the eye from the OCT image;

determining geometric dimensions of the intraocular elements from the OCT image, wherein the intraocular elements comprise a subretinal bleb of a therapeutic agent;

creating an optical model of the eye with respect to the intraoperative OCT system using at least one of the determined geometric dimensions of the features of the eye from the OCT image and known dimensions of elements within the intraoperative OCT system; and

applying the optical model to the OCT image.

2 . The method of claim 1 , wherein creating the optical model of the eye with respect to the intraoperative OCT system comprises:

adjusting a default model of the eye using the geometric dimensions of the elements within the eye from the OCT image; and

using known dimensions of elements within the intraoperative OCT system.

3 . The method of claim 1 , wherein applying the optical model to the OCT image comprises calculating a volume of an intraocular element using the determined geometric dimensions for that intraocular element within the eye from the OCT image and the optical model.

4 . The method of claim 3 , further comprising:

determining that the volume of the intraocular element is less than a specified volume of the intraocular element; and

in response to determining that the volume of the intraocular element is less than the specified volume of the intraocular element, providing, via a display, a recommendation for insertion of an additional volume of the intraocular element into the eye.

5 . The method of claim 1 , further comprising:

capturing a second image of the features of the eye, wherein the second image includes an intraocular element;

wherein applying the optical model to the image comprises calculating a volume of the intraocular element based on the optical model and the second image.

6 . The method of claim 5 , wherein the intraocular element is not present when the image of the features of the eye is captured before creating the optical model.

7 . The method of claim 1 , wherein the image of the features of the eye includes an intraocular element, the method further comprising determining a location of at least a portion of the intraocular element based on the optical model and the OCT image.

8 . The method of claim 1 , wherein the known dimensions of elements within the intraoperative OCT system comprise a distance related to placement of an optical system of the intraoperative OCT system.

9 . The method of claim 8 , wherein the optical system is a contact indirect retinal viewing system, wherein the distance related to the placement of the optical system comprises a distance between an initial position of an intermediate image plane of the contact indirect retinal viewing system and a position for imaging a retina of the eye.

10 . The method of claim 8 , wherein the optical system is a non-contact indirect retinal viewing system, wherein the distance related to the placement of the optical system comprises a distance between an objective of the intraoperative OCT system and a bottom lens of the optical system of the non-contact indirect retinal viewing system.

11 . The method of claim 1 , wherein the determined geometric dimensions of the elements within the eye from the OCT image comprise an axial eye length.

12 . The method of claim 1 , wherein applying the optical model to the OCT image comprises determining an additional volume of an intraocular element is needed;

wherein the method further comprises directing the additional volume of the intraocular element to be inserted into the eye.

13 . The method of claim 1 , further comprising:

capturing a second image of the features of the eye, wherein the second image comprises an intraocular element;

wherein applying the optical model to the OCT image comprises calculating a volume of an intraocular element within the eye based on the optical model and the second image to determine whether the calculated volume of the intraocular element satisfies a specified condition; and

upon determining that the calculated volume of the intraocular element satisfies the specified condition, outputting a signal indicating satisfaction of the specified condition.

14 . The method of claim 1 , further comprising calibrating the optical model by determining axial and lateral voxel pitches based on the geometric dimensions of the elements within the eye.

15 . The method of claim 1 , further comprising visually correcting the OCT image of the features of the eye.

16 . An intraoperative optical coherence tomography (OCT) system for imaging intraocular structures, comprising:

an optical system; and

a processing system coupled to the optical system, the processing system comprises a processor, memory, and instructions stored on the memory that when executed by the processor, direct the intraoperative OCT system to:

capture an OCT image of features of an eye and intraocular elements introduced to the eye, wherein the intraocular elements comprise a subretinal bleb of a therapeutic agent;

determine geometric dimensions of the features of the eye from the OCT image;

determine geometric dimensions of the intraocular elements from the OCT image;

create an optical model of the eye with respect to the intraoperative OCT system using at least one of the determined geometric dimensions of the features of the eye from the OCT image and known dimensions of elements within the intraoperative OCT system; and

apply the optical model to the OCT image.

17 . The intraoperative OCT system of claim 16 , wherein the instructions to create the optical model of the eye with respect to the intraoperative OCT system comprises instructions to:

adjust a default model of the eye using the geometric dimensions of the elements within the eye from the image; and

use known dimensions of elements within the intraoperative OCT system.

18 . The intraoperative OCT system of claim 16 , wherein the instructions to apply the optical model to the OCT image comprises instructions to calculate a volume of an intraocular element using the determined geometric dimensions for that intraocular element within the eye from the OCT image and the optical model.

19 . The intraoperative OCT system of claim 16 , wherein the instructions further direct the processing system to:

capture a second image of the features of the eye, wherein the second image includes an intraocular element;

wherein the instructions to apply the optical model comprise instructions to calculate a volume of the intraocular element based on the optical model and the second image.

20 . The method of claim 1 , wherein the subretinal bleb of the therapeutic agent is in a subretinal space between a retina of the eye and a retinal pigment epithelium of the eye.