Ingestible device for sampling material and method for using the same
An ingestible device for sampling material at least one time is provided. The ingestible device includes a first chamber that is enlargeable in volume and that includes an inlet, and that can be filled with the material to be sampled, a second chamber that is diminishable in volume and that includes an outlet, and a reversible actuating mechanism. The reversible actuating mechanism is configured such that triggering the reversible actuating mechanism leads to an enlargement of the first chamber to collect the material to be sampled through the inlet and also leads to a diminishment of the second chamber.
1 . An ingestible device for sampling material at least one time, the ingestible device comprising:
a first chamber having an enlargeable volume, wherein the first chamber comprises an inlet, and wherein the first chamber is capable of being filled with the material to be sampled;
a second chamber having a diminishable volume, wherein the second chamber comprises an outlet;
a third chamber having an enlargeable volume, wherein the third chamber comprises a further inlet, and wherein the third chamber is capable of being filled with further material to be sampled;
a fourth chamber having a diminishable volume, wherein the fourth chamber comprises a further outlet;
a reversible actuating mechanism, wherein the reversible actuating mechanism is configured to, in response to triggering the reversible actuating mechanism, cause (i) an enlargement of the first chamber, thereby collecting the material to be sampled in the first chamber via the inlet and (ii) a diminishment of the second chamber; and
a further reversible actuating mechanism, wherein the further reversible actuating mechanism is configured to, in response to triggering the further reversible actuating mechanism, cause (i) an enlargement of the third chamber, thereby collecting further material in the third chamber via the further inlet and (ii) a diminishment of the fourth chamber.
2 . The ingestible device of claim 1 ,
wherein the inlet is configured to be sealed following collection of the material in the first chamber when the material is collected.
3 . The ingestible device of claim 1 , further comprising: a substance to be released that is disposed within the second chamber, wherein diminishment of the second chamber results in release of the substance to be released via the outlet.
4 . The ingestible device of claim 3 , wherein the substance to be released is a drug.
5 . The ingestible device of claim 1 , wherein at least one of: (i) the first chamber and the second chamber are axisymmetric with respect to the third chamber and the fourth chamber; (ii) the first chamber and the second chamber are point-symmetric with respect to the third chamber and the fourth chamber, (iii) the first chamber and the second chamber are rotationally symmetric with respect to the same axis, (iv) the reversible actuating mechanism is at least one of axisymmetric or point-symmetric with respect to the further reversible actuating mechanism, or (v) the reversible actuating mechanism and the further reversible actuating mechanism are rotationally symmetric with respect to the same axis.
6 . The ingestible device of claim 1 , wherein the reversible actuating mechanism comprises:
a spring that is compressed prior to triggering the reversible actuating mechanism; and
an electrically conductive alloy portion, wherein triggering the reversible actuating mechanism comprises conductively connecting the electrically conductive alloy portion to an energy source, wherein connecting the electrically conductive alloy portion to the energy source results in a reversible deformation of the electrically conductive alloy portion due to Joule heating,
wherein such a reversible deformation of the electrically conductive alloy portion results in a decompression of the spring, wherein such a decompression of the spring results in (i) enlargement of the first chamber and (ii) diminishment of the second chamber.
7 . The ingestible device of claim 6 , wherein the reversible actuating mechanism further comprises:
at least one ball release member, wherein the reversible deformation of the electrically conductive alloy portion results in a movement of the at least one ball release member into at least one indentation, thereby decompressing the spring.
8 . The ingestible device of claim 1 , wherein the inlet comprises a passive one-way valve.
9 . The ingestible device of claim 8 , wherein the passive one-way valve is an umbrella valve.
10 . The ingestible device of claim 1 , wherein the first chamber comprises a removable portion that provides access to an internal space of the first chamber.
11 . The ingestible device of claim 10 , wherein the removable portion is a screwable cap.
12 . The ingestible device of claim 1 , wherein the material to be sampled is gastrointestinal content.
13 . The ingestible device of claim 1 , further comprising a stabilizing substance disposed in the first chamber.
14 . The ingestible device of claim 13 , wherein the stabilizing substance comprises a quencher that reduces a rate of chemical reaction of the material to be sampled.
15 . The ingestible device of claim 1 , wherein the ingestible device further comprises a body portion having a hollow inner space that is sealed against an environment of the body portion, wherein the first chamber and the second chamber are attached to the body portion.
16 . The ingestible device of claim 15 , further comprising, disposed within the hollow inner space of the body portion, at least one of:
an energy source configured to supply energy to the reversible actuating mechanism;
a remote trigger unit to receive at least one remote trigger signal and, in response to receiving the at least one remote trigger signal, trigger the reversible actuating mechanism;
a data recording unit configured to record at least one of environment data or localization data;
a wireless data transmission unit configured to wirelessly transmit at least one of environment data or localization data; or
a pH-value sensor.
17 . The ingestible device of claim 1 , wherein a length of the ingestible device is less than 24 millimeters and a diameter of the ingestible device is less than 9 millimeters.
18 . The ingestible device of claim 1 , wherein the ingestible device has a shape of a pill or cylinder.
19 . The ingestible device of claim 1 , further comprising a stabilizing substance disposed in the third chamber.