Method and apparatus for laser ablation under ultrasound guidance
A method for minimally invasive laser ablation of a target tissue within a patient while sparing tissue within a safety zone proximate to the target tissue, comprising: guiding a laser fiber within a patient with a guidance tool; measuring a temperature within the target tissue and the safety zone based on an invasive and a non-invasive thermal sensor; computing a thermal profile in conjunction with a real-time tissue image adapted for guidance of the laser fiber with the guidance tool within the patient; and controlling a laser to deliver energy through the laser fiber, to deliver a minimally therapeutic ablation therapy to the target tissue while ensuring that the safety zone is maintained in a non-ablation condition, based on at least a treatment plan, the measured temperature, and the thermal profile.
1 . A system for performing minimally invasive laser ablation of a target tissue within a patient while sparing tissue within a safety zone proximate to the target tissue, comprising:
a guidance tool configured to guide a laser fiber within a patient;
a controller configured to control a laser to deliver energy through the laser fiber;
an invasive thermal sensor and a non-invasive thermal sensor; and
at least one automated processor configured to:
measure a temperature within the target tissue using one or more of the invasive thermal sensor and the non-invasive thermal sensor,
measure a temperature within the safety zone using one or more of the invasive thermal sensor and the non-invasive thermal sensor,
control the controller to deliver a minimally therapeutic ablation therapy to the target tissue based on at least a treatment plan, while ensuring that the safety zone is maintained in a non-ablation condition,
compute a thermal profile of the target tissue and the safety zone based on at least a combination of the temperatures measured by the invasive thermal sensor and the non-invasive thermal sensor in conjunction with a real-time tissue image adapted for guidance of the laser fiber with the guidance tool within the patient,
generate a thermal map based on the thermal profile, wherein the thermal map illustrates:
the combination of the temperatures measured by the invasive thermal sensor and the non-invasive thermal sensor,
an isothermal region representing a highest temperature allowable within the safety zone, and
an isothermal region representing a lowest temperature allowable within the target tissue, and
cause the thermal map to be overlaid on the real-time ultrasound image.
2 . The system according to claim 1 , wherein the guidance tool is configured to automatically control insertion of the laser fiber into the patient.
3 . The system according to claim 1 , wherein the controller is further configured to define a duration and dosage of laser energy delivered through the laser fiber.
4 . The system according to claim 1 , wherein the non-invasive thermal sensor comprises an ultrasound thermometer.
5 . The system according to claim 1 , wherein the at least one automated processor is further configured to communicate with the controller to deactivate the delivery of laser energy through the laser fiber based on the computed thermal profile.
6 . The system according to claim 1 , wherein the guidance tool is configured to guide the invasive thermal sensor into the safety zone.
7 . The system according to claim 1 , wherein the invasive and the non-invasive thermal sensor comprises a combination of a hypodermic thermal sensor, a surface thermal sensor, and an ultrasound signal analysis thermal sensor, which are together analyzed by the at least one automated processor to provide an accurate temperature measurement.
8 . The system according to claim 1 , wherein the guidance tool comprises a perforated plate having a regular array of holes configured to guide the laser fiber.
9 . The system according to claim 1 , wherein the guidance tool comprises a perforated plate having a regular array of holes configured to guide the invasive thermal sensor.
10 . The system according to claim 9 , wherein the first imaging modality comprises at least one of PET, CT, MM, and MRSI, and the real-time tissue imager comprises an ultrasonic imager.
11 . A method for minimally invasive laser ablation of a target tissue within a patient while sparing tissue within a safety zone proximate to the target tissue, comprising:
guiding a laser fiber within a patient with a guidance tool;
measuring a temperature within the target tissue using one or more of an invasive thermal sensor and a non-invasive thermal sensor;
computing a thermal profile of the target tissue and the safety zone based on at least a combination the temperatures measured by the invasive thermal sensor and the non-invasive thermal sensor in conjunction with a real-time tissue image adapted for guidance of the laser fiber with the guidance tool within the patient; and
controlling a laser to deliver energy through the laser fiber, to deliver a minimally therapeutic ablation therapy to the target tissue while ensuring that the safety zone is continually maintained in a non-ablation condition, based on at least a treatment plan, the measured temperature, and the thermal profile;
generating a thermal map based on the thermal profile, wherein the thermal map illustrates the combination of the temperatures measured by the invasive thermal sensor and the non-invasive thermal sensor, an isocontour representing a highest temperature allowable within the safety zone, and an isocontour representing a lowest temperature allowable within the target tissue; and
causing the thermal map to be overlaid on the real-time ultrasound image.
12 . The method according to claim 11 , wherein the guidance tool automatically controls insertion of the laser fiber into the patient.
13 . The method according to claim 11 , wherein the non-invasive thermal sensor comprises an ultrasound thermometer.
14 . The method according to claim 13 , wherein the ultrasound thermometer further generates the real-time image of at least the target tissue during ablation.
15 . The method according to claim 11 , further comprising guiding the invasive thermal sensor within the patient with the guidance tool.
16 . The method according to claim 11 , further comprising guiding the invasive thermal sensor within the safety zone with the guidance tool.
17 . The method according to claim 11 , wherein the invasive and the non-invasive thermal sensor comprises a combination of a hypodermic thermal sensor, a surface thermal sensor, and an ultrasound signal analysis thermal sensor, which are together analyzed to provide an accurate temperature measurement.
18 . The method according to claim 11 , wherein the guidance tool comprises a perforated plate having a regular array of holes configured to guide the laser fiber and the invasive thermal sensor.
19 . The method according to claim 11 , wherein the guidance tool is mounted to an ultrasonic transducer for generating a real-time ultrasound image, and has an array of guided trajectories which define at least one plane of a virtual grid and which guide the laser fiber along a respective guided trajectory.
20 . A non-transitory computer readable medium which stores computer readable instructions to control a programmable processor, for support of minimally invasive laser ablation of a target tissue within a patient while sparing tissue within a safety zone proximate to the target tissue, to perform the steps of:
receiving data representing at least one temperature within a target tissue and the safety zone based on information from at least one invasive thermal sensor and at least one non-invasive thermal sensor;
computing a thermal profile of the target tissue and the safety zone based on at least a combination of the at least one temperature within a target tissue and the safety zone based on information from the at least one invasive thermal sensor and the at least one non-invasive thermal sensor in conjunction with a real-time tissue image adapted for guidance of a laser fiber toward the target tissue;
controlling a laser to deliver energy through the laser fiber, to deliver a minimally therapeutic ablation therapy to the target tissue while ensuring that the safety zone is continually maintained in a non-ablation condition, based on at least a treatment plan, the measured temperature, and the thermal profile;
generating a thermal map basal on the thermal profile, wherein the thermal map illustrates the combination of the temperatures measured by the invasive thermal sensor and the non-invasive thermal sensor, an isocontour representing a highest temperature allowable within the safety zone, and an isocontour representing a lowest temperature allowable within the target tissue; and
causing the thermal map to be overlaid on the real-time ultrasound image.