Film coated tablet
An object of the present invention is to provide a film coated tablet that has an excellent tablet slipperiness in an oral cavity and prevents delay in disintegration time of an uncoated tablet. The present invention provides a film coated tablet including a tablet, a first film layer that coats the tablet and contains an inorganic salt, and a second film layer that coats the tablet coated with the first film layer and contains a thickener, and a film coated tablet including a tablet, a first film layer that coats the tablet, and a second film layer that coats an outside of the first film layer and contains a thickener, in which the first film layer contains an inorganic salt, and the inorganic salt reduces a viscosity of the thickener contained in the second film layer.
1 . A film coated tablet, comprising:
a tablet;
a first film layer that coats the tablet and contains (a) a first water-soluble film base selected from hydroxypropyl methylcellulose, hydroxypropylcellulose, and a combination thereof and (b) an inorganic salt selected from the group consisting of potassium phosphate, sodium hydrogen carbonate, sodium chloride, and a combination thereof; and
a second film layer that coats the tablet coated with the first film layer and contains (a) a second water-soluble film base selected from hydroxypropyl methylcellulose, hydroxypropylcellulose, and a combination thereof and (b) a thickener selected from the group consisting of sodium alginate, xanthan gum, and a combination thereof.
2 . A film coated tablet, comprising:
a tablet;
a first film layer that coats the tablet and contains (a) a first water-soluble film base selected from hydroxypropyl methylcellulose, hydroxypropylcellulose, and a combination thereof and (b) an inorganic salt selected from the group consisting of potassium phosphate, sodium hydrogen carbonate, sodium chloride, and a combination thereof; and
a second film layer that coats an outside of the first film layer and contains (a) a second water-soluble film base selected from hydroxypropyl methylcellulose, hydroxypropylcellulose, and a combination thereof and (b) a thickener selected from the group consisting of sodium alginate, xanthan gum, and a combination thereof,
wherein the inorganic salt in the first film layer reduces a viscosity of the thickener contained in the second film layer.
3 . A film coated tablet, comprising:
a tablet;
a first film layer that coats the tablet and contains (a) a first water-soluble film base selected from hydroxypropyl methylcellulose, hydroxypropylcellulose, and a combination thereof and (b) an inorganic salt selected from the group consisting of potassium phosphate, sodium hydrogen carbonate, sodium chloride, and a combination thereof; and
a second film layer that coats an outside of the first film layer and contains (a) a second water-soluble film base selected from hydroxypropyl methylcellulose, hydroxypropylcellulose, and a combination thereof and (b) a thickener selected from the group consisting of sodium alginate, xanthan gum, and a combination thereof,
wherein the first water-soluble film base has a 2% by mass aqueous solution viscosity at 20° C. of 100 mPa·s or less.
4 . The film-coated tablet according to claim 1 , wherein a content of the inorganic salt in the first film layer is 20 to 55% by mass, and a content of the thickener in the second film layer is 20 to 40% by mass.
5 . The film-coated tablet according to claim 1 , wherein the first film layer is 2 to 6 parts by mass per 100 parts by mass of the tablet, and the second film layer is 2 to 4 parts by mass per 100 parts by mass of the tablet.
6 . The film-coated tablet according to claim 1 , wherein the inorganic salt contained in the first film layer is a water-soluble inorganic salt.
7 . The film-coated tablet according to claim 2 , wherein a content of the inorganic salt in the first film layer is 20 to 55% by mass, and a content of the thickener in the second film layer is 20 to 40% by mass.
8 . The film-coated tablet according to claim 2 , wherein the first film layer is 2 to 6 parts by mass per 100 parts by mass of the tablet, and the second film layer is 2 to 4 parts by mass per 100 parts by mass of the tablet.
9 . The film-coated tablet according to claim 2 , wherein the inorganic salt contained in the first film layer is a water-soluble inorganic salt.
10 . The film-coated tablet according to claim 3 , wherein a content of the inorganic salt in the first film layer is 20 to 55% by mass, and a content of the thickener in the second film layer is 20 to 40% by mass.
11 . The film-coated tablet according to claim 3 , wherein the first film layer is 2 to 6 parts by mass per 100 parts by mass of the tablet, and the second film layer is 2 to 4 parts by mass per 100 parts by mass of the tablet.
12 . The film-coated tablet according to claim 3 , wherein the inorganic salt contained in the first film layer is a water-soluble inorganic salt.
13 . The film-coated tablet according to claim 1 , wherein a content of the first water-soluble film base in the first film layer is 30 to 80% by mass, and a content of the second water-soluble film base in the second film layer is 30 to 70% by mass.
14 . The film-coated tablet according to claim 13 , wherein a content of the inorganic salt in the first film layer is 20 to 55% by mass, and a content of the thickener in the second film layer is 20 to 40% by mass.
15 . The film-coated tablet according to claim 2 , wherein a content of the first water-soluble film base in the first film layer is 30 to 80% by mass, and a content of the second water-soluble film base in the second film layer is 30 to 70% by mass.
16 . The film-coated tablet according to claim 15 , wherein a content of the inorganic salt in the first film layer is 20 to 55% by mass, and a content of the thickener in the second film layer is 20 to 40% by mass.
17 . The film-coated tablet according to claim 3 , wherein a content of the first water-soluble film base in the first film layer is 30 to 80% by mass, and a content of the second water-soluble film base in the second film layer is 30 to 70% by mass.
18 . The film-coated tablet according to claim 17 , wherein a content of the inorganic salt in the first film layer is 20 to 55% by mass, and a content of the thickener in the second film layer is 20 to 40% by mass.