Emollient compositions comprising linoleic acid and conjugated linoleic acid and methods of use
Emollient compositions and their use to treat inflammatory skin disorders including plaque psoriasis, particularly emollient compositions comprising a combination of linoleic acid and conjugated linoleic acid.
1 . An emollient composition comprising:
(a) a 3-component combination of
(i) a LA/CLA combination, wherein the linoleic acid and the conjugated linoleic acid are present at a weight ratio of from 2:1 to 1:2,
(ii) a ceramide, and
(iii) a cholesterol, and
(b) an emollient base,
wherein the linoleic acid and the conjugated linoleic acid are the only polyunsaturated fatty acids present in the emollient composition.
2 . The composition of claim 1 , wherein the emollient composition comprises the ceramide, the LA/CLA combination, and the cholesterol in a physiologically balanced ratio of (3±10%): (1±10%): (1±10%).
3 . The composition of claim 1 , further comprising water, wherein the emollient composition comprises from 25 to 50 wt. % emollient base, and from 50 to 75 wt. % water.
4 . The composition of claim 1 , further comprising water, wherein the emollient composition comprises from 25 to 50 wt. % emollient base, from 50 to 75 wt. % water, and wherein the 3-component combination is present in an amount of from 1 to 10 wt. % of the emollient composition.
5 . The composition of claim 1 , wherein the emollient composition has a pH of from 4.2 to 4.85.
6 . The composition of claim 1 , wherein the emollient composition is an emulsion that further comprises water, glyceryl stearate, squalene, glycerin, PEG-100 stearate, petrolatum, dimethicone, phenoxyethanol, citric acid, palmitic acid, xanthan gum, potassium hydroxide, disodium EDTA, sorbic acid, capric acid, and one or more additional lipids.
7 . The composition of claim 1 , wherein the linoleic acid and conjugated linoleic acid are present at a weight ratio of about 1:1.