IP Library › Granted Patent US 12661334
Granted Patent B2
US 12661334 · App. 17/595,516 · Granted Jun 23, 2026

Dietary butyrate and its uses

Inventors: Amaury Patin (Lausanne, CH); Elizabeth Forbes-Blom (Epalinges, CH); Sameer Kulkarni (Copenhagen, DK)
Assignee: Societe des Produits Nestle S.A.
A61K31/231A61P3/06
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Quick Facts
Patent No.
US 12661334
App. No.
17/595,516
Granted
Jun 23, 2026
Kind
B2
Abstract

Use of a compound having the formula (1), (2), (3) or (4), or combinations thereof, for providing a source of butyrate with improved organoleptic properties wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently a long chain fatty acid having between 16 and 20 carbons the prevention and/or treatment of non alcoholic fatty liver disease.

Claims (12)

1 . A method for the prevention and/or treatment of non alcoholic fatty liver disease, the method comprising administering to an individual in need thereof a composition comprising compounds having the formulas

wherein the compound having formula (5) comprises at least 10% by weight of the total triglycerides in the composition, and wherein the compound having formula (6) comprises at least 10% by weight of the total triglycerides in the composition.

2 . The method according to claim 1 , wherein the compound having formula (5) comprises at least 15% by weight of the total triglycerides in the composition, and wherein the compound having formula (6) comprises at least 20% by weight of the total triglycerides in the composition.

3 . The method according to claim 1 , further comprising administering a compound having the formula

and/or a compound having the formula

4 . A method for the prevention and/or treatment of non alcoholic fatty liver disease, the method comprising administering to an individual in need thereof a composition comprising compounds having the formulas

wherein the compound having formula (5) comprises at least 10% by weight of the total butyrate moiety containing triglycerides in the composition, and wherein the compound having formula (6) comprises at least 10% by weight of the total butyrate moiety containing triglycerides in the composition.

5 . The method according to claim 4 , wherein the compound having formula (5) comprises at least 15%, and wherein the compound having formula (6) comprises at least 20%, by weight of the total butyrate moiety containing triglycerides in the composition.

6 . The method according to claim 4 , wherein the composition further comprises compounds having the formulas

wherein the compound having formula (7) comprises at least 2% by weight of the total butyrate moiety containing triglycerides in the composition, and the compound having formula (8) comprises at least 2% by weight of the total butyrate moiety containing triglycerides in the composition.

7 . The method according to claim 4 , wherein the composition is a nutritional composition.

8 . The method according to claim 1 , wherein the composition is an infant formula, a follow-on formula or a dietary supplement.