Methods for treating ocular
Disclosed herein are methods for treating or preventing ophthalmic and dermatologic conditions in a patient, including ocular surface conditions such as blepharitis. The methods can include topically administering directly to an ocular surface of one or more eyes of a patient in need of treatment thereof an effective amount of an isoxazoline parasiticide, formamidine parasiticide, or other active ingredient, formulated into an ophthalmic composition, the ophthalmic composition further comprising a pharmaceutically acceptable vehicle. Compositions are also disclosed.
1 . A method for treating an ocular Demodex mite infestation, comprising topically administering to one or more of the eye, eyelid, or eyelashes of a human patient in need of treatment thereof an effective amount of a composition comprising spinosad and an isoxazoline parasiticide.
2 . The method of claim 1 , wherein the composition is formulated as an eye drop.
3 . The method of claim 1 , wherein the composition is formulated as an ointment.
4 . The method of claim 1 , wherein the composition is formulated as a cream.
5 . The method of claim 1 , wherein the composition is formulated as an emulsion.
6 . The method of claim 1 , wherein the composition is formulated as a suspension.
7 . The method of claim 1 , wherein the Demodex mite infestation comprises one or more of Demodex folliculorum mites and Demodex brevis mites.
8 . The method of claim 1 , wherein the isoxazoline parasiticide comprises lotilaner.
9 . The method of claim 1 , wherein the composition further comprises tea tree oil.
10 . The method of claim 1 , wherein the ocular Demodex mite infestation causes blepharitis.
11 . The method of claim 1 , wherein the ocular Demodex mite infestation causes meibomian gland dysfunction.
12 . The method of claim 1 , wherein the ocular Demodex mite infestation causes ocular rosacea.
13 . The method of claim 1 , wherein the composition further comprises an antibiotic agent.
14 . The method of claim 1 , further comprising confirming the presence of Demodex mites prior to the topically administering.
15 . The method of claim 14 , wherein confirming the presence of Demodex mites comprises identifying cylindrical dandruff, identifying Demodex mites, or testing for the presence of a biomarker associated with Demodex mites.
16 . The method of claim 1 , wherein the composition comprises an additional agent having miticidal activity against the Demodex mite.
17 . The method of claim 16 , wherein the additional agent is selected from the group consisting of: ivermectin, moxidectin, metronidazole, and amitraz.
18 . A method for treating meibomian gland dysfunction caused by an ocular Demodex mite infestation, comprising topically administering to one or more of the eyelid or eyelashes of a human patient in need of treatment thereof an effective amount of a composition comprising spinosad and an isoxazoline parasiticide.
19 . A method for treating Demodex blepharitis , comprising topically administering to one or more of the eyelid or eyelashes of a human patient in need of treatment thereof an effective amount of a composition comprising spinosad and an isoxazoline parasiticide.