Compositions containing nicotinamide and vitamin B6 and methods of using such compositions for promoting muscle growth
A composition contains Nicotinamide and Vitamin B6, for example pyridoxine. The composition may be an oral nutritional composition, for example an infant formula, a follow up formula, a nutritional supplement, an oral nutritional supplement, a food product. The composition can be administered to an individual in need thereof for promoting muscle growth and/or for maintaining and/or increasing muscle function and/or muscle mass in infants and children. For example, the composition can be useful for increasing muscle function and/or muscle mass by modulating muscle stem cells.
1 . A method for promoting muscle growth and/or increasing muscle function and/or muscle mass in an infant, a young child, or a child in need thereof, the method comprising administering to the infant, young child, or child a composition comprising a combination of Vitamin B6 and Nicotinamide in a therapeutically effective amount.
2 . The method according to claim 1 , wherein promotion of muscle growth is achieved by increasing muscle function and/or muscle mass.
3 . The method according to claim 1 , wherein the vitamin B6 is administered in an amount of 1.0-200 mg vitamin B6 per day.
4 . The method according to claim 1 , wherein the Nicotinamide is administered in an amount of about 0.001 mg/day to about 2000 mg/day.
5 . The method according to claim 1 , wherein the Vitamin B6 and Nicotinamide are present in the composition in a ratio of from about 1:100 to about 1:9.
6 . The method according to claim 1 , wherein the Vitamin B6 and Nicotinamide are present in the composition in a ratio of from about 1:45 to about 1:30.
7 . The method according to claim 1 , wherein the composition is in a form selected from the group consisting of an oral nutritional composition, an infant formula, a follow up formula, a nutritional supplement, an oral nutritional supplement, a medical food, a food supplement, a food product, and a food for special medical purpose (FSMP).
8 . The method according to claim 1 , wherein the composition is in a form selected from the group consisting of a solid powder, a powdered stick, a capsule and a solution.
9 . The method according to claim 1 , wherein the administering of the composition promotes muscle growth in the subject.
10 . The method according to claim 1 , wherein the composition is a food product further comprising a component selected from the group consisting of protein, carbohydrate, fat and mixtures thereof.
11 . The method according to claim 1 , wherein Vitamin B6 is pyridoxine.
12 . A method for promoting muscle growth and/or increasing muscle function and/or muscle mass in an infant, a young child, or a child in need thereof, the method comprising administering to the infant, young child, or child (i) a first composition comprising Vitamin B6 and (ii) a second composition comprising Nicotinamide.
13 . The method according to claim 12 , wherein the first composition is administered to provide 1.0-200 mg of the vitamin B6 per day.
14 . The method according to claim 12 , wherein the second composition is administered to provide about 0.001 mg-about 2000 mg of the Nicotinamide per day.
15 . The method according to claim 12 , wherein the first and second compositions are administered to provide the Vitamin B6 and the Nicotinamide in a ratio of from about 1:100 to about 1:9.
16 . The method according to claim 12 , wherein the first and second compositions are administered to provide the Vitamin B6 and the Nicotinamide in a ratio of from about 1:45 to about 1:30.