Remedy for hair growth enhancing
The invention relates to the field of cosmetology, dermatology and medicine, and is concerned with the development and production of a combination, and also of a composition based thereon, for hair growth enhancing in mammals and/or for preventing and/or treating alopecia, primarily in humans, and more particularly to combinations based on derivatives of F- and E-type prostaglandins, characterized by the absence of undesirable side-effects, and also to a stable composition comprising said combination. The use of a combination of prostaglandins in a single composition makes it possible to simultaneously activate a plurality of physiological processes, including stimulating a hair follicle to produce a new hair, increasing the local microcirculation in the area adjacent to the hair follicle, and reducing the aggregation of thrombocytes, thereby preventing thrombogenesis in the capillary network. Furthermore, the presence in the combination or in the composition based thereon of modified prostaglandins carrying a group of nitrogen oxide donors enables better penetration of other ingredients of the combination or composition into the skin.
1 . A combination for hair growth enhancing and/or prevention and/or treatment of alopecia in a subject, comprising at least a compound of formula (I) and a compound of formula (II) and/or formula (III),
wherein the compound of formula (I) is:
the compound of formula (II) is:
the compound of formula (III) is:
2 . The combination according to claim 1 , comprising a compound of formula (I), formula (II) and formula (III).
3 . The combination according to claim 1 , comprising a compound of formula (I) and formula (II).
4 . The combination according to claim 1 , comprising a compound of formula (I) and formula (III).
5 . The combination according to claim 1 , wherein alopecia is androgenetic, diffuse or alopecia areata.
6 . A composition for hair growth enhancing and/or prevention and/or treatment of alopecia, comprising the combination according to claim 1 and at least one excipient.
7 . The composition of claim 6 , wherein the components of the combination are in an effective quantity.
8 . The composition of claim 6 , wherein the excipient is a carrier, filler and/or solvent.
9 . The composition of claim 6 , wherein the content of the compound of general formula (I) in the combination is 50-300 μg per 1 mL of the finished composition.
10 . The composition of claim 6 , wherein the content of the compound of general formula (II) in the combination is 50-300 μg per 1 mL of the finished composition.
11 . The composition of claim 6 , wherein the content of the compound of general formula (III) in the combination is 50-200 μg per 1 mL of the finished composition.
12 . A method of hair growth enhancing and/or prevention and/or treatment of alopecia in a subject, comprising administering a composition comprising the combination according to claim 1 and at least one excipient.
13 . The method according to claim 12 , wherein alopecia is androgenetic, diffuse or alopecia areata.
14 . The method according to claim 12 , wherein the composition is applied topically.
15 . The method according to claim 14 , wherein the composition is applied daily or every other day.
16 . The method according to claim 12 , wherein the subject is a human.