Methods and materials for tissue ablation
This document relates to methods and materials for tissue ablation. For example, methods for using a composition including one or more ionic liquids (e.g., a composition including a LATTE solution) for tissue ablation are provided. In some cases, a composition including one or more ionic liquids (e.g., a composition including a LATTE solution) can be used to ablate tumor tissue within a mammal having cancer (e.g., to treat the mammal).
1 . A method for ablating at least a portion of a tissue within a mammal, wherein said method comprises percutaneously injecting a composition comprising an ionic liquid into said tissue within said mammal,
wherein said ionic liquid comprises:
(a) a cationic component comprising choline; and
(b) an anionic component comprising geranate;
wherein the composition does not comprise any additional therapeutic agent,
wherein the choline and geranate are in a ratio of 1:1,
wherein said composition is in the form of an aqueous solution or a hydrogel comprising a nanosilicate and is effective to create an ablation zone within said tissue,
wherein when the composition is aqueous, the composition comprises 10-90% (w/w) of the choline geranate, and wherein said composition is effective to reduce the number of cells within said ablation zone.
2 . The method of claim 1 , wherein said mammal is a human.
3 . The method of claim 1 , wherein said tissue is selected from the group consisting of fat tissue, cardiac tissue, connective tissue, bone tissue, synovial tissue, abscess tissue, and cysts.
4 . The method of claim 3 , wherein said percutaneously injecting step comprises a guided injection.
5 . The method of claim 4 , wherein said composition comprising an ionic liquid further comprises a contrast agent.
6 . The method of claim 5 , wherein said contrast agent is selected from the group consisting of indocyanine green, a radiodense contrast agent, iohexol, tantalum nanoparticles, tantalum microparticles, gold nanoparticles, gadolinium, indium 111 , and microbubbles.
7 . The method of claim 1 , wherein said ablation zone is from about 0.1 cm to about 4 cm.
8 . A method for treating a mammal having cancer, wherein said method comprises percutaneously injecting a composition comprising an ionic liquid into a tumor tissue within said mammal,
wherein said ionic liquid comprises:
(a) a cationic component comprising choline; and
(b) an anionic component comprising geranate;
wherein the composition does not comprise any additional therapeutic agent,
wherein the choline and geranate are in a ratio of 1:1,
wherein said composition is in the form of an aqueous solution or a hydrogel comprising a nanosilicate and is effective to create an ablation zone within said tumor tissue,
wherein when the composition is aqueous, the composition comprises 10-90% (w/w) of the choline geranate, and
wherein said composition is effective to reduce the number of cancer cells within said ablation zone.
9 . The method of claim 8 , wherein said mammal is a human.
10 . The method of claim 8 , wherein said cancer is selected from the group consisting of a liver cancer, a bile duct cancer, a pancreatic cancer, a colorectal cancer, a renal cancer, an ovarian cancer, a breast cancer, a prostate cancer, a colon cancer, a bladder cancer, a lung cancer, a thyroid cancer, a melanoma, a brain cancer, a stomach cancer, a cervical cancer, a uterine cancer, a skin cancer, a synovial cancer, an appendiceal cancer, and an adrenal cancer.
11 . The method of claim 8 , wherein said percutaneously injecting step comprises a guided injection, and wherein said composition comprises a contrast agent.
12 . The method of claim 11 , wherein said contrast agent is selected from the group consisting indocvanine green, a radiodense contrast agent, iohexol, tantalum nanoparticles, tantalum microparticles, gold nanoparticles, gadolinium, indium 111 , and microbubbles.
13 . The method of claim 11 , wherein said ionic liquid choline geranate.
14 . The method of claim 11 , wherein said method is effective to maintain said ionic liquid within said ablation zone for from about 1 day to about 30 days.
15 . The method of claim 8 , wherein said method is effective to reduce the size of said cancer by at least 2-fold.
16 . The method of claim 8 , said method comprising identifying said mammal as having said cancer.
17 . The method of claim 1 , wherein said composition is in the form of a hydrogel.
18 . The method of claim 17 , wherein said hydrogel comprises from about 1% (w/v) to about 10% (w/v) of said nanosilicate.
19 . The method of claim 18 , wherein said nanosilicate comprises a smectite clay.
20 . The method of claim 1 , wherein said composition is in the form of an aqueous solution.