IP Library Granted Patent US 12661833
Granted Patent B2
US 12661833 · App. 18/271,756 · Granted Jun 23, 2026

Method and system for producing microstructures

Inventors: Michael Kulik (Urmitz, DE); Olga Grünwald (Koblenz, DE); Philip Roos (Kettig, DE); Nikolaj Tissin (Sinzig, DE)
Assignee: LTS Lohmann Therapie-Systeme AG
B29C43/56B29C39/24B29C39/42B29C43/34B29C43/46B29C2043/3483B29C2043/561B29C2791/006B29L2031/756
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Quick Facts
Patent No.
US 12661833
App. No.
18/271,756
Granted
Jun 23, 2026
Kind
B2
Abstract

The invention relates to a method for producing microstructures, the method including providing a planar mold element, which includes at least one mold opening for the microstructure to be produced, wherein the at least one mold opening has a first opening and a second opening; providing a first formulation at the second opening; generating a negative pressure in the mold opening; and taking up the first formulation through the second opening into the mold opening on account of the negative pressure in the mold opening. The invention further relates to a system for producing microstructures.

Claims (43)

1 . A method for producing microstructures, the method comprising the steps of:

providing a planar mold element, which comprises at least one mold for the microstructure to be produced, each of the at least one mold having a first opening and a second opening, wherein the second opening is located opposite the first opening;

providing a first formulation at the second opening, wherein the formulation contains an active ingredient;

reducing a volume of the at least one mold, wherein reducing the volume of the at least one mold is achieved by a compression of the mold element;

generating a negative pressure in the at least one mold; and

taking up the first formulation through the second opening into the at least one mold on account of the negative pressure in the at least one mold,

wherein the step of reducing the volume of the at least one mold by a compression of the mold element occurs prior to an expansion of the volume of the at least one mold, and

wherein the compression is achieved by pressing and bending of the mold element so as to reduce the volume of the at least one mold.

2 . The method of claim 1 , further comprising the step of expanding the volume of the at least one mold to generate the negative pressure in the at least one mold.

3 . The method according to claim 1 , wherein the compression of the mold element is performed using at least one roll.

4 . The method according to claim 1 , further comprising, prior to the step of generating the negative pressure in the at least one mold, the step of arranging an auxiliary element on a side of the mold element having the first opening.

5 . The method according to claim 1 , further comprising, prior to the step of generating the negative pressure in the at least one mold, the step of closing the first opening of the at least one mold.

6 . The method according to claim 4 , further comprising, after the taking-up of the first formulation into the second opening of the at least one mold, removing the auxiliary element from the mold element.

7 . The method according to claim 1 , wherein the at least one mold is cylindrical or conical.

8 . The method according to claim 1 , wherein the mold element comprises a film.

9 . The method according to claim 1 , further comprising, after the taking-up of the first formulation, the steps of:

providing a second formulation at the first opening, the second formulation being free of an active ingredient; and

taking up the second formulation into the at least one mold through the first opening, the second formulation bonding with the first formulation.

10 . The method according to claim 9 , wherein providing the first formulation is performed using a first formulation element designed as a film, the first formulation element comprising the first formulation; and/or wherein providing the second formulation is performed using a second formulation element designed as a film, the second formulation element comprising the second formulation.

11 . The method according to claim 9 , further comprising the step of demolding the first formulation, which has at least partially solidified to form a microstructure, and the second formulation at the first opening of the at least one mold.

12 . The method according to claim 11 , wherein the demolding step is performed using a cover element comprising a cover film, which cover element is substance-bonded with the first formulation; and/or the step demolding is performed by pulling off the mold element.

13 . The method according to claim 11 , further comprising the step of packaging the demolded microstructure using a blister element.

14 . The method according to claim 1 , wherein the method is performed using a system that is designed to form microstructures.

15 . A method for producing microstructures, the method comprising the steps of:

providing a planar mold element, which comprises at least one mold for the microstructure to be produced, each of the at least one mold having a first opening and a second opening, wherein the second opening is located opposite the first opening;

providing a first formulation at the second opening, wherein the formulation contains an active ingredient;

reducing a volume of the at least one mold, wherein reducing the volume of the at least one mold is achieved by a compression of the mold element;

generating a negative pressure in the at least one mold;

taking up the first formulation through the second opening into the at least one mold on account of the negative pressure in the at least one mold;

providing a second formulation at the first opening, the second formulation being free of an active ingredient;

taking up the second formulation into the at least one mold through the first opening, the second formulation bonding with the first formulation; and

demolding the first formulation, which has at least partially solidified, and the second formulation at the first opening of the at least one mold to form a microstructure,

wherein the step of reducing the volume of the at least one mold by the compression of the at least one mold element occurs prior to an expansion of the volume of the at least one mold.

16 . A method for producing microstructures, the method comprising the steps of:

providing a planar mold element, which comprises at least one mold for the microstructure to be produced, each of the at least one mold having a first opening and a second opening, wherein the second opening is located opposite the first opening;

providing a first formulation at the second opening, wherein the formulation contains an active ingredient;

reducing a volume of the at least one mold, wherein reducing the volume of the at least one mold is achieved by a compression of the mold element;

generating a negative pressure in the at least one mold;

taking up the first formulation through the second opening into the at least one mold on account of the negative pressure in the at least one mold; and

expanding the volume of the at least one mold to generate the negative pressure in the at least one mold,

wherein the step of reducing the volume of the at least one mold by the compression of the mold element occurs prior to an expansion of the volume of the at least one mold,

wherein the compression is achieved by pressing and bending of the mold element so as to reduce the volume of the at least one mold, and

wherein the compression of the mold element is performed using at least one roll.