Compounds

1 . A compound of formula (I):

wherein:

R 1 is C 1-4 alkyl or C 3-5 cycloalkyl;

R 2 is C 1-4 alkyl; or

R 1 and R 2 join to form a 5-7 membered heterocycloalkyl;

R 3 is selected from the group consisting of C 1-3 alkyl and halo;

R 4 is selected from the group consisting of C 1-3 alkyl, halo, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, NR 4a R 4b and 4-7 membered heterocycloalkyl;

wherein:

R 4a is selected from the group consisting of H and C 1-3 alkyl;

R 4b is selected from the group consisting of H and C 1-3 alkyl;

m is 0, 1 or 2;

n is 0, 1 or 2;

and R 5 , R 6 and R 7 are defined as follows:

(a) R 6 is

 and R 7 is absent;

R 5 is selected from the group consisting of H, halo, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, SC 1-3 alkyl, SC 1-3 haloalkyl, OC 3-10 cycloalkyl, NR 5b R 5c and 4-7 membered heterocycloalkyl, wherein the OC 3-10 cycloalkyl and 4-7 membered heterocycloalkyl are optionally substituted by one or more R 5a ;

wherein:

R 5a is selected from the group consisting of halo and C 1-3 alkyl, or two R 5a groups which are attached to the same carbon atom join to form a C 3-6 cycloalkyl or 4-7 membered heterocycloalkyl ring;

R 5b is selected from the group consisting of H and C 1-3 alkyl; and

R 5c is selected from the group consisting of C 1-3 alkyl and C 3-6 cycloalkyl; and

R 8 is selected from the group consisting of C 3-6 cycloalkyl, NR 8b R 8c and 4-10 membered heterocycloalkyl, wherein the C 3-6 cycloalkyl and 4-10 membered heterocycloalkyl are optionally substituted by one or more R 8a , wherein:

R 8a is selected from the group consisting of C 1-3 alkyl, C 1-3 alkyl substituted by OH, C 1-2 alkyl substituted by OC 1-2 alkyl, C 1-3 alkoxy, halo and C 1-3 haloalkyl;

R 8b is selected from the group consisting of H, C 1-3 alkyl and C 3-6 cycloalkyl;

R 8c is selected from the group consisting of H, C 1-3 alkyl and C 3-6 cycloalkyl;

or:

(b) R 7 is

 and

(i) R 6 is H and R 5 is selected from the group consisting of H, halo, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, SC 1-3 alkyl, SC 1-3 haloalkyl, OC 3-10 cycloalkyl, NR 5b R 5c and 4-7 membered heterocycloalkyl, wherein the OC 3-10 cycloalkyl and 4-7 membered heterocycloalkyl are optionally substituted by one or more R 5a ;

wherein:

R 5a is selected from the group consisting of halo and C 1-3 alkyl, or two R 5a groups which are attached to the same carbon atom join to form a C 3-6 cycloalkyl or 4-7 membered heterocycloalkyl ring,

R 5b is selected from the group consisting of H and C 1-3 alkyl; and

R 5c is selected from the group consisting of C 1-3 alkyl and C 3-6 cycloalkyl;

or

(ii) R 5 is H and R 6 is selected from the group consisting of H, halo, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, SC 1-3 alkyl, SC 1-3 haloalkyl, OC 3-10 cycloalkyl, NR 6b R 6c and 4-7 membered heterocycloalkyl, wherein the OC 3-10 cycloalkyl and 4-7 membered heterocycloalkyl are optionally substituted by one or more R 6a ;

wherein:

R 6a is selected from the group consisting of halo and C 1-3 alkyl, or two R 6a groups which are attached to the same carbon atom join to form a C 3-6 cycloalkyl or 4-7 membered heterocycloalkyl ring,

R 6b is selected from the group consisting of H and C 1-3 alkyl; and

R 6c is selected from the group consisting of C 1-3 alkyl and C 3-6 cycloalkyl;

or

(iii) R 5 and R 6 join to form a 4-8 membered heterocyclic ring;

and

R 8 is selected from the group consisting of C 3-6 cycloalkyl, NR 8b R 8c and 4-10 membered heterocycloalkyl, wherein the C 3-6 cycloalkyl and 4-10 membered heterocycloalkyl are optionally substituted by one or more R 8a wherein:

R 8a is selected from the group consisting of C 1-3 alkyl, C 1-3 alkyl substituted by OH, C 1-2 alkyl substituted by OC 1-2 alkyl, C 1-3 alkoxy, halo and C 1-3 haloalkyl;

R 8b is selected from the group consisting of H, C 1-3 alkyl and C 3-6 cycloalkyl; and

R 8c is selected from the group consisting of H, C 1-3 alkyl and C 3-6 cycloalkyl;

or a pharmaceutically acceptable salt and/or solvate thereof.

2 . A compound of formula (I) according to claim 1 :

wherein:

R 1 is C 1-4 alkyl or C 3-5 cycloalkyl;

R 2 is C 1-4 alkyl; or

R 1 and R 2 join to form a 5-7 membered heterocycloalkyl;

R 3 is selected from the group consisting of C 1-3 alkyl and halo;

R 4 is selected from the group consisting of C 1-3 alkyl, halo, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, NR 4a R 4b and 4-7 membered heterocycloalkyl;

wherein:

R 4a is selected from the group consisting of H and C 1-3 alkyl;

R 4b is selected from the group consisting of H and C 1-3 alkyl;

m is 0, 1 or 2;

n is 0, 1 or 2;

and R 5 , R 6 and R 7 are defined as follows:

(a) R 6 is

 and R 7 is absent;

R 5 is selected from the group consisting of H, halo, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, SC 1-3 alkyl, SC 1-3 haloalkyl, OC 3-10 cycloalkyl, NR 5b R 5c and 4-7 membered heterocycloalkyl, wherein the OC 3-10 cycloalkyl and 4-7 membered heterocycloalkyl are optionally substituted by one or more R 5a ;

wherein:

R 5a is selected from the group consisting of halo and C 1-3 alkyl, or two R 5a groups which are attached to the same carbon atom join to form a C 3-6 cycloalkyl or 4-7 membered heterocycloalkyl ring;

R 5b is selected from the group consisting of H and C 1-3 alkyl; and

R 5c is selected from the group consisting of C 1-3 alkyl and C 3-6 cycloalkyl; and

R 8 is selected from the group consisting of C 3-6 cycloalkyl, NR 8b R 8c and 4-8 membered heterocycloalkyl, wherein the C 3-6 cycloalkyl and 4-8 membered heterocycloalkyl are optionally substituted by one or more R 8a , wherein:

R 8a is selected from the group consisting of C 1-3 alkyl, halo and C 1-3 haloalkyl;

R 8b is selected from the group consisting of H, C 1-3 alkyl and C 3-6 cycloalkyl;

R 8c is selected from the group consisting of H, C 1-3 alkyl and C 3-6 cycloalkyl;

or:

(b) R 7 is

 and

(i) R 6 is H and R 5 is selected from the group consisting of H, halo, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, SC 1-3 alkyl, SC 1-3 haloalkyl, OC 3-10 cycloalkyl, NR 5b R 5c and 4-7 membered heterocycloalkyl, wherein the OC 3-10 cycloalkyl and 4-7 membered heterocycloalkyl are optionally substituted by one or more R 5a ;

wherein:

R 5a is selected from the group consisting of halo and C 1-3 alkyl, or two R 5a groups which are attached to the same carbon atom join to form a C 3-6 cycloalkyl or 4-7 membered heterocycloalkyl ring,

R 5b is selected from the group consisting of H and C 1-3 alkyl; and

R 5c is selected from the group consisting of C 1-3 alkyl and C 3-6 cycloalkyl;

or

(ii) R 5 is H and R 6 is selected from the group consisting of H, halo, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, SC 1-3 alkyl, SC 1-3 haloalkyl, OC 3-10 cycloalkyl, NR 6b R 6c and 4-7 membered heterocycloalkyl, wherein the OC 3-10 cycloalkyl and 4-7 membered heterocycloalkyl are optionally substituted by one or more R 6a ;

wherein:

R 6a is selected from the group consisting of halo and C 1-3 alkyl, or two R 6a groups which are attached to the same carbon atom join to form a C 3-6 cycloalkyl or 4-7 membered heterocycloalkyl ring,

R 6b is selected from the group consisting of H and C 1-3 alkyl; and

R 6c is selected from the group consisting of C 1-3 alkyl and C 3-6 cycloalkyl;

or

(iii) R 5 and R 6 join to form a 4-8 membered heterocyclic ring;

and

R 8 is selected from the group consisting of C 3-6 cycloalkyl, NR 8b R 8c and 4-8 membered heterocycloalkyl, wherein the C 3-6 cycloalkyl and 4-8 membered heterocycloalkyl are optionally substituted by one or more R 8a wherein:

R 8a is selected from the group consisting of C 1-3 alkyl, halo and C 1-3 haloalkyl;

R 8b is selected from the group consisting of H, C 1-3 alkyl and C 3-6 cycloalkyl; and

R 8c is selected from the group consisting of H, C 1-3 alkyl and C 3-6 cycloalkyl;

or a pharmaceutically acceptable salt and/or solvate thereof.

3 . A compound of formula (I) according to claim 1 :

wherein:

R 1 is C 1-4 alkyl or C 3-5 cycloalkyl;

R 2 is C 1-4 alkyl; or

R 1 and R 2 join to form a 5-7 membered heterocycloalkyl;

R 3 is selected from the group consisting of C 1-3 alkyl and halo;

R 4 is selected from the group consisting of C 1-3 alkyl, halo, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy and 4-7 membered heterocycloalkyl;

R 6 is

 and R 7 is absent; or

R 7 is

wherein:

when R 6 is

 and R 7 is absent:

R 5 is selected from the group consisting of H, halo, C 1-3 alkoxy, C 1-3 haloalkoxy, SC 1-3 alkyl, SC 1-3 haloalkyl, OC 3-10 cycloalkyl, NR 5b R 5c and 4-7 membered heterocycloalkyl, wherein the OC 3-10 cycloalkyl and 4-7 membered heterocycloalkyl are optionally substituted by one or more R 5a ;

wherein:

R 5a is selected from the group consisting of halo and C 1-3 alkyl, or two R 5a groups which are attached to the same carbon atom join to form a C 3-6 cycloalkyl or 4-7 membered heterocycloalkyl ring;

R 5b is selected from the group consisting of H and C 1-3 alkyl; and

R 5c is selected from the group consisting of C 1-3 alkyl and C 3-6 cycloalkyl; and

R 8 is selected from the group consisting of C 3-6 cycloalkyl, N(C 1-3 alkyl) 2 and 4-8 membered heterocycloalkyl, wherein the C 3-6 cycloalkyl and 4-8 membered heterocycloalkyl are optionally substituted by one or more R 8a , wherein R 8a is selected from the group consisting of C 1-3 alkyl, halo and C 1-3 haloalkyl;

or:

when R 7 is

R 6 is H and R 5 is selected from the group consisting of H, halo, C 1-3 alkoxy, C 1-3 haloalkoxy, SC 1-3 alkyl, SC 1-3 haloalkyl, OC 3-10 cycloalkyl, NR 5b R 5c and 4-7 membered heterocycloalkyl, wherein the OC 3-10 cycloalkyl and 4-7 membered heterocycloalkyl are optionally substituted by one or more R 5a ;

wherein:

R 5a is selected from the group consisting of halo and C 1-3 alkyl, or two R 5a groups which are attached to the same carbon atom join to form a C 3-6 cycloalkyl or 4-7 membered heterocycloalkyl ring,

R 5b is selected from the group consisting of H and C 1-3 alkyl; and

R 5c is selected from the group consisting of C 1-3 alkyl and C 3-6 cycloalkyl;

or

R 5 is H and R 6 is selected from the group consisting of H, halo, C 1-3 alkoxy, C 1-3 haloalkoxy, SC 1-3 alkyl, SC 1-3 haloalkyl, OC 3-10 cycloalkyl, NR 6b R 6c and 4-7 membered heterocycloalkyl, wherein the OC 3-10 cycloalkyl and 4-7 membered heterocycloalkyl are optionally substituted by one or more R 6a ;

wherein:

R 6a is selected from the group consisting of halo and C 1-3 alkyl, or two R 6a groups which are attached to the same carbon atom join to form a C 3-6 cycloalkyl or 4-7 membered heterocycloalkyl ring,

R 6b is selected from the group consisting of H and C 1-3 alkyl; and

R 6c is selected from the group consisting of C 1-3 alkyl and C 3-6 cycloalkyl;

or

R 5 and R 6 join to form a 4-7 membered heterocyclic ring; and

R 8 is selected from the group consisting of C 3-6 cycloalkyl, N(C 1-3 alkyl) 2 and 4-8 membered heterocycloalkyl, wherein the C 3-6 cycloalkyl and 4-8 membered heterocycloalkyl are optionally substituted by one or more R 8a wherein R 8a is selected from the group consisting of C 1-3 alkyl, halo and C 1-3 haloalkyl;

m is 0, 1 or 2; and

n is 0, 1 or 2;

or a pharmaceutically acceptable salt and/or solvate thereof.

4 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 1 wherein R 1 is methyl and R 2 is methyl.

5 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 1 wherein m is 2 and R 3 is methyl or wherein m is 1 and R 3 is chloro.

6 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 1 wherein n is 1 and R 4 is selected from the group consisting of chloro and fluoro.

7 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 1 wherein:

R 6 is

 and R 7 is absent.

8 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 7 wherein R 5 is C 1-3 alkoxy e.g. methoxy or ethoxy, or OC 3-10 cycloalkyl e.g. cyclobutyloxy or cyclopentyloxy.

9 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 7 which is a compound of formula (IC):

wherein R 1 , R 2 , R 3 , m and R 4 are as defined in claim 1 , R 6 as defined in claim 7 and R 5 is methoxy, ethoxy, cyclopropyloxy or NR 5b R 5c and wherein R 5b and R 5c are as defined in claim 1 .

10 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 1 wherein R 5 is NR 5b R 5c wherein R 5b and R 5c are each methyl.

11 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 1 wherein R 8 is C 3-6 cycloalkyl e.g. cyclopropyl and R 8 is substituted by one R 8a group e.g. methyl, or wherein R 8 is 4-8 membered heterocycloalkyl e.g. e.g. pyrrolidinyl, 7-azanorbornanyl, 3-azabicyclo[3.1.0]hexyl, 6-azaspiro[2.5]octyl or 3-oxa-6-azabicyclo[3.2.1]octyl.

12 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 11 wherein R 8 is pyrrolidinyl e.g. pyrrolidin-1-yl.

13 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 1 which is selected from the list consisting of:

(R)-2-cyclobutoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl) benzamide;

(R)-2-cyclobutoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl) benzamide;

(R)-2-cyclobutoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl) benzamide;

(R)-2-(cyclopentyloxy)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl) benzamide;

(R)-2-(cyclopentyloxy)-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-4-(7-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(cyclopentyloxy)-3-fluoro-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-cyclobutoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(cyclopentyloxy)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(cyclopentyloxy)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-4-(7-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-cyclobutoxy-N-((1-methylcyclopropyl)sulfonyl)benzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(cyclopentyloxy)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-4-(7-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-cyclobutoxy-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-2-(pyrrolidin-1-yl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)—N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(pyrrolidin-1-yl)benzamide;

(R)-2-cyclobutoxy-4-(8-(hexahydropyrazino [2,1-c][1,4]oxazin-8(1H)-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(pyrrolidin-1-yl)benzamide;

(R)-2-cyclobutoxy-4-(8-(hexahydropyrazino [2,1-c][1,4]oxazin-8(1H)-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-6-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-N—(N,N-dimethylsulfamoyl)-6-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(cyclopentyloxy)-3-fluoro-N—(N-isopropyl-N-methylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-cyclobutoxy-3-fluoro-N—(N-isopropyl-N-methylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-6-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N—(N,N-dimethylsulfamoyl)-6-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N—(N,N-dimethylsulfamoyl)-6-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-4-(7-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(cyclopentyloxy)-3-fluoro-N—(N-isopropyl-N-methylsulfamoyl)benzamide;

(R)-4-(7-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-cyclobutoxy-3-fluoro-N—(N-isopropyl-N-methylsulfamoyl)benzamide;

(R)—N—(N-isopropyl-N-methylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(pyrrolidin-1-yl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-6-chloro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-6-chloro-N—(N,N-dimethylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-6-chloro-N—(N,N-dimethylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-3-fluoro-N—(N-isopropyl-N-methylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(cyclobutyl(methyl)amino)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(cyclobutyl(methyl)amino)-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-6-chloro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-cyclobutoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-cyclobutoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(cyclopentyloxy)-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-4-(7-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(cyclopentyloxy)-N—(N,N-dimethylsulfamoyl)-3-fluorobenzamide;

(R)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-2-(pyrrolidin-1-yl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N—(N,N-dimethylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-cyclobutoxy-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-cyclobutoxy-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-4-(7-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-cyclobutoxy-N—(N,N-dimethylsulfamoyl)-3-fluorobenzamide;

(R)-4-(7-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-cyclobutoxy-3-fluoro-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-cyclobutoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(cyclobutyl(methyl)amino)-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-cyclobutoxy-3-fluoro-N—(N-isopropyl-N-methylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-4-(7-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(cyclopentyloxy)-3-fluoro-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(cyclopentyloxy)-3-fluoro-N—(N-isopropyl-N-methylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-4-(7-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-3-fluoro-N-((1-methylcyclopropyl)sulfonyl)benzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-4-(7-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N—(N,N-dimethylsulfamoyl)-3-fluorobenzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-4-(7-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-3-fluoro-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-3-fluoro-N—(N-isopropyl-N-methylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-4-(7-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-3-fluoro-N—(N-isopropyl-N-methylsulfamoyl)benzamide;

2-(((1R,3s,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-(((1R,3s,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(((1R,3,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-2-(pyrrolidin-1-yl)benzamide;

(R)—N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(pyrrolidin-1-yl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(3,3-difluoropiperidin-1-yl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(3,3-difluoropiperidin-1-yl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(3,3-difluoropiperidin-1-yl)-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(3,3-difluoropiperidin-1-yl)-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(dimethylamino)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-6-chloro-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(3,3-difluoropyrrolidin-1-yl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(3,3-difluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(cyclopropyl(methyl)amino)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(cyclopropyl(methyl)amino)-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-((4,4-difluorocyclohexyl)oxy)-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-((4,4-difluorocyclohexyl)oxy)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(3,3-dimethylpyrrolidin-1-yl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(3,3-dimethylpyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(azetidin-1-yl)-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-((adamantan-2-yl)oxy)-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(azetidin-1-yl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(3,3-difluoropyrrolidin-1-yl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-cyclobutoxy-N—(N,N-dimethylsulfamoyl)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-((adamantan-2-yl)oxy)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-((4,4-difluorocyclohexyl)oxy)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-((adamantan-2-yl)oxy)-N—(N,N-dimethylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(cyclopentyloxy)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-6-(trifluoromethyl)benzamide;

N—(N,N-dimethylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-((R)-2-methylpyrrolidin-1-yl)benzamide;

N—(N,N-dimethylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-((S)-2-methylpyrrolidin-1-yl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-6-(trifluoromethyl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-6-chloro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-methyl-6-(pyrrolidin-1-yl)benzamide;

(R)-2-(cyclopentyloxy)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-6-(trifluoromethyl)benzamide;

2-(bicyclo[3.1.0]hexan-3-yloxy)-N—(N,N-dimethylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(bicyclo[3.1.0]hexan-3-yloxy)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(24yrrolidine-1-ylsulfonyl)benzamide;

(R)-2-(cyclopentyloxy)-N—(N,N-dimethylsulfamoyl)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(cyclopentyloxy)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-6-(trifluoromethyl)benzamide;

2-(bicyclo[3.1.0]hexan-3-yloxy)-N—(N,N-dimethylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(bicyclo[3.1.0]hexan-3-yloxy)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-(2-azabicyclo[2.2.1]heptan-2-yl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-(2-azabicyclo[2.2.1]heptan-2-yl)-N—(N,N-dimethylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(cyclopentyloxy)-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-6-(trifluoromethyl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N—(N,N-dimethylsulfamoyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-6-(trifluoromethyl)benzamide;

(R)—N—(N,N-dimethylsulfamoyl)-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-6-(pyrrolidin-1-yl)benzamide;

(R)—N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(5-azaspiro[2.5]octan-5-yl)benzamide;

(R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-((S)-2-methylpyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-2-((R)-2-methylpyrrolidin-1-yl)benzamide;

4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-((R)-2-methylpyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-2-((S)-2-methylpyrrolidin-1-yl)benzamide;

2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(cyclopentyloxy)-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-6-(pyrrolidin-1-yl)benzamide;

(R)-2-(cyclopentyloxy)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-6-(trifluoromethyl)benzamide;

(R)-2-(cyclopentyloxy)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-6-(trifluoromethyl)benzamide;

(R)-2-cyclobutoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-6-(trifluoromethyl)benzamide;

(S)-2-cyclobutoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-cyclobutoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-6-(trifluoromethyl)benzamide;

(R)-2-cyclobutoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-6-(trifluoromethyl)benzamide;

(R)—N—(N,N-dimethylsulfamoyl)-3-fluoro-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-3-fluoro-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(dimethylamino)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(dimethylamino)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(dimethylamino)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(dimethylamino)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-cyclobutoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-5-methyl-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-2-(pyrrolidin-1-yl)benzamide;

(R)-2-cyclobutoxy-4-(8-(3-(ethoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-3-fluoro-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(dimethylamino)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(dimethylamino)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)—N—(N,N-dimethylsulfamoyl)-2-ethoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide; (R)-2-ethoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N—(N,N-dimethylsulfamoyl)-3-fluoro-2-isopropoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-3-fluoro-2-isopropoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-5-chloro-2-(dimethylamino)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-5-chloro-2-(dimethylamino)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-2-(dimethylamino)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-5-(trifluoromethyl)benzamide;

(R)-2-(cyclopentyloxy)-N—(N,N-dimethylsulfamoyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-6-(trifluoromethyl)benzamide;

(R)-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-6-(trifluoromethyl)benzamide;

(R)—N-((6-azaspiro[2.5]octan-6-yl)sulfonyl)-3-fluoro-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-3-fluoro-2-methoxy-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-3-fluoro-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-oxa-8-azabicyclo[3.2.1]octan-8-yl)sulfonyl)-3-fluoro-2-methoxy-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(dimethylamino)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-5-(trifluoromethyl)benzamide;

(R)-2-ethoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-6-(trifluoromethyl)benzamide;

(R)-2-isopropoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-6-(trifluoromethyl)benzamide;

(R)-2-cyclobutoxy-5-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-3-cyclobutoxy-5-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-6-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)spiro[benzo[d][1,3]dioxole-2,1′-cyclobutane]-4-carboxamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-cyclobutoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-cyclobutoxy-4-fluoro-5-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-3-cyclobutoxy-4-fluoro-5-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-cyclobutoxy-N-(((2R,5R)-2,5-dimethylpyrrolidin-1-yl)sulfonyl)-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-cyclobutoxy-N—(N,N-dimethylsulfamoyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-cyclobutoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-3-methyl-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)-4-fluoro-5-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)spiro[benzo[d][1,3]dioxole-2,1′-cyclobutane]-7-carboxamide;

(R)-2-(dimethylamino)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((1-methylcyclopropyl)sulfonyl)-5-(trifluoromethyl)benzamide;

(R)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-2-(trifluoromethoxy)benzamide;

(R)-2-chloro-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-cyclobutoxy-3-fluoro-4-(8-(4-isopropyl-3-(methoxymethyl) piperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(difluoromethoxy)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-cyclobutoxy-4-(8-(4-ethyl-3-(methoxymethyl) piperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-3-fluoro-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-cyclobutoxy-4-(8-(4-cyclopropyl-3-(methoxymethyl) piperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-3-fluoro-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(S)-2-cyclobutoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(S)-2-cyclobutoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-2-(dimethylamino)-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-cyclobutoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(cyclopentyloxy)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-3-chloro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-3-chloro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-cyclobutoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-10-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(cyclopentyloxy)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-10-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-(dimethylamino)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((6-azaspiro[2.5]octan-6-yl)sulfonyl)-2-(dimethylamino)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((6-azaspiro[2.5]octan-6-yl)sulfonyl)-5-chloro-2-(dimethylamino)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-(dimethylamino)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-cyclobutoxy-3-fluoro-4-(8-(3-(isopropoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-5-chloro-2-(dimethylamino)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(azetidin-1-yl)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-amino-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-ethoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(piperidin-1-ylsulfonyl)benzamide;

(R)-2-ethoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(piperidin-1-ylsulfonyl)benzamide;

(R)—N—(N-cyclopentyl-N-methylsulfamoyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-(cyclobutyl(methyl)amino)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(methylamino)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-ethoxy-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-2-(azetidin-1-yl)-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-3-fluoro-N-((4-fluoropiperidin-1-yl)sulfonyl)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-propoxy-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-2-(2,2,2-trifluoroethoxy)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-2-cyclopropoxy-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-4-(7-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-ethoxy-3-fluorobenzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-4-(7-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-ethoxy-3-fluorobenzamide;

N-(((3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl)sulfonyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((octahydro-2H-isoindol-2-yl)sulfonyl)benzamide;

(R)-2-cyclopropoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-cyclopropoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-2-ethoxy-4-(7-ethyl-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-3-fluorobenzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-ethoxy-4-(7-ethyl-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-3-fluorobenzamide;

(R)—N—(N,N-dicyclopropylsulfamoyl)-2-ethoxy-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((3,3-dimethylpyrrolidin-1-yl)sulfonyl)-2-ethoxy-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-ethoxy-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-2-ethoxy-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((2-azaspiro[3.3]heptan-2-yl)sulfonyl)-2-ethoxy-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-oxa-8-azabicyclo[3.2.1]octan-8-yl)sulfonyl)-2-ethoxy-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)-2-(3,3,3-trifluoropropoxy)benzamide;

(R)-3-ethoxy-2-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-5-fluoro-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-5-fluoro-2-(methoxy-d3)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-ethoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-ethoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-2-ethoxy-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((2-azabicyclo[2.2.1]heptan-2-yl)sulfonyl)-2-ethoxy-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N—(N,N-dicyclopropylsulfamoyl)-2-ethoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-ethoxy-3-fluoro-N-(((3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl)sulfonyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((2-azaspiro[3.3]heptan-2-yl)sulfonyl)-2-ethoxy-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((8-azabicyclo[3.2.1]octan-8-yl)sulfonyl)-2-ethoxy-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-azabicyclo[3.2.1]octan-3-yl)sulfonyl)-2-ethoxy-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((8-azabicyclo[3.2.1]octan-8-yl)sulfonyl)-2-ethoxy-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-azabicyclo[3.2.1]octan-3-yl)sulfonyl)-2-ethoxy-3-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N—(N-cyclopentyl-N-methylsulfamoyl)-3-fluoro-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-3-fluoro-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(piperidin-1-ylsulfonyl)benzamide;

(R)-3-fluoro-N-((4-fluoropiperidin-1-yl)sulfonyl)-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-methylbenzamide;

(R)-5-(dimethylamino)-2-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-ethyl-3-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-ethoxy-4-(10-ethyl-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-5-fluoro-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-(dimethylamino)-4-(10-ethyl-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-5-fluoro-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-5-fluoro-2-(methoxy-d3)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluoro-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-5-fluoro-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-5-fluoro-2-methoxy-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-5-fluoro-2-(methoxy-d3)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-5-fluoro-2-(methoxy-d3)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-3-fluoro-2-(methoxy-d3)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((2-azaspiro[3.3]heptan-2-yl)sulfonyl)-2-(dimethylamino)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(dimethylamino)-5-fluoro-N-(((S)-3-fluoropyrrolidin-1-yl)sulfonyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-(dimethylamino)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-oxa-8-azabicyclo[3.2.1]octan-8-yl)sulfonyl)-2-(dimethylamino)-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N—(N-cyclopropyl-N-methylsulfamoyl)-2-(dimethylamino)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-ethoxy-3-fluoro-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-ethoxy-5-fluoro-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-N—(N,N-dimethylsulfamoyl)-5-fluorobenzamide;

2-ethoxy-5-fluoro-N—(((R)-3-fluoropyrrolidin-1-yl)sulfonyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-5-fluoro-2-methoxy-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-cyclopropoxy-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-2-cyclopropoxy-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-2-fluoro-5-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

N-(((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)sulfonyl)-2-ethoxy-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-ethoxy-5-fluoro-N-(((S)-3-fluoropyrrolidin-1-yl)sulfonyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N—(N-cyclopropyl-N-methylsulfamoyl)-2-ethoxy-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-2-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-5-methyl-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N-((2-oxa-5-azaspiro[3.5]nonan-5-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluorobenzamide;

(R)—N-((2-oxa-6-azaspiro[3.5]nonan-6-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluorobenzamide;

R)—N-((2-oxa-6-azaspiro[3.4]octan-6-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluorobenzamide;

(R)—N-((5-azaspiro[2.4]heptan-5-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluorobenzamide;

R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluoro-N-(piperidin-1-ylsulfonyl)benzamide;

(R)—N—(N,N-dicyclopropylsulfamoyl)-2-(dimethylamino)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N—(N, N-dicyclopropylsulfamoyl)-2-(dimethylamino)-5-fluorobenzamide;

4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluoro-N—(((R)-2-(trifluoromethyl) pyrrolidin-1-yl)sulfonyl)benzamide;

(R)—N-((2-azaspiro[3.3]heptan-2-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-methoxybenzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-methoxybenzamide;

2-(dimethylamino)-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(((S)-3-methoxypiperidin-1-yl)sulfonyl)benzamide;

(R)—N-((2-oxa-6-azaspiro[3.3]heptan-6-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluorobenzamide;

4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-methoxy-N-(((S)-2-(methoxymethyl) pyrrolidin-1-yl)sulfonyl)benzamide;

4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluoro-N-(((S)-3-methoxypyrrolidin-1-yl)sulfonyl)benzamide;

4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluoro-N—(((R)-3-methoxypyrrolidin-1-yl)sulfonyl)benzamide;

2-(dimethylamino)-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N—(((R)-3-methoxypiperidin-1-yl)sulfonyl)benzamide;

2-(dimethylamino)-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N—(((R)-2-(trifluoromethyl) pyrrolidin-1-yl)sulfonyl)benzamide;

4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-methoxy-N—(((R)-2-(methoxymethyl) pyrrolidin-1-yl)sulfonyl)benzamide;

(R)-2-(dimethylamino)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((4-methoxypiperidin-1-yl)sulfonyl)benzamide;

4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluoro-N—(((R)-2-(methoxymethyl) pyrrolidin-1-yl)sulfonyl)benzamide;

(R)-5-chloro-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-N—(N,N-dimethylsulfamoyl)benzamide;

2-(dimethylamino)-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(((S)-2-(trifluoromethyl) pyrrolidin-1-yl)sulfonyl)benzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluoro-N-((4-(trifluoromethyl) piperidin-1-yl)sulfonyl)benzamide;

N-(((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)sulfonyl)-4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluorobenzamide;

4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluoro-N-(((S)-2-(trifluoromethyl) pyrrolidin-1-yl)sulfonyl)benzamide;

(R)-2-(dimethylamino)-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-((4-(trifluoromethyl) piperidin-1-yl)sulfonyl)benzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N—(N, N-dicyclopropylsulfamoyl)-5-fluoro-2-methoxybenzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N—(N-cyclopropyl-N-methylsulfamoyl)-2-ethoxy-5-fluorobenzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-ethoxy-5-fluoro-N-((1-methylcyclopropyl)sulfonyl)benzamide;

(R)—N-((2-azaspiro[3.3]heptan-2-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-ethoxy-5-fluorobenzamide;

N-((8-oxa-3-azabicyclo[3.2.1]octan-3-yl)sulfonyl)-4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-ethoxy-5-fluorobenzamide;

4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluoro-N-(((S)-3-fluoropyrrolidin-1-yl)sulfonyl)benzamide;

4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluoro-N—(((R)-3-fluoropyrrolidin-1-yl)sulfonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-(dimethylamino)-5-fluoro-4-(10-fluoro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-5-fluoro-4-(10-fluoro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-methoxybenzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-cyclopropoxy-N—(N,N-dimethylsulfamoyl)-5-fluorobenzamide;

N-((3-oxa-8-azabicyclo[3.2.1]octan-8-yl)sulfonyl)-4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-cyclopropoxy-5-fluorobenzamide;

(R)-2-(dimethylamino)-5-fluoro-4-(10-fluoro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-5-fluoro-4-(10-fluoro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-methoxy-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-fluoro-5-methyl-N-(pyrrolidin-1-ylsulfonyl)benzamide;

2-(dimethylamino)-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N—(((R)-2-(methoxymethyl) pyrrolidin-1-yl)sulfonyl)benzamide;

2-(dimethylamino)-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(((S)-2-(methoxymethyl) pyrrolidin-1-yl)sulfonyl)benzamide;

N-(((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)sulfonyl)-2-(dimethylamino)-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

2-(dimethylamino)-5-fluoro-N—(((R)-3-fluoropyrrolidin-1-yl)sulfonyl)-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-2-(dimethylamino)-5-fluoro-4-(8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluorobenzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-ethoxy-5-fluorobenzamide;

(R)—N-((2-azaspiro[3.3]heptan-2-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluorobenzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-fluoro-5-methoxy-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-ethoxybenzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-methoxybenzamide;

N-((3-oxa-8-azabicyclo[3.2.1]octan-8-yl)sulfonyl)-4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(dimethylamino)-5-fluorobenzamide;

(R)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N—(N-cyclopropyl-N-methylsulfamoyl)-2-(dimethylamino)-5-fluorobenzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-5-fluoro-2-methoxybenzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-5-fluoro-2-methoxybenzamide;

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-4-(10-chloro-8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-5-fluoro-2-(methoxy-d3)benzamide;

N-((3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl)-4-(10-chloro-8-((R)-3-(methoxymethyl)-4-methylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-5-fluoro-2-(methoxy-d3)benzamide;

(R)-5-chloro-2-(methoxy-d3)-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-5-chloro-2-methoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide;

(R)-5-chloro-2-ethoxy-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-N-(pyrrolidin-1-ylsulfonyl)benzamide; and

(R)—N-((7-azabicyclo[2.2.1]heptan-7-yl)sulfonyl)-2-cyclopropoxy-5-fluoro-4-(8-(3-(methoxymethyl)-4-methylpiperazin-1-yl)-7,10-dimethyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzamide;

or a pharmaceutically acceptable salt and/or solvate of any one thereof.

14 . A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt and/or solvate thereof according to claim 1 and one or more pharmaceutically acceptable diluents or carriers.

15 . A method of treating a disease selected from inflammatory, autoimmune and fibrotic diseases, and cancer, which comprises administering a compound or salt and/or solvate thereof according to claim 1 .

16 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 9 wherein R 1 is methyl and R 2 is methyl.

17 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 9 wherein m is 2 and R 3 is methyl or wherein m is 1 and R 3 is chloro.

18 . The compound or a pharmaceutically acceptable salt and/or solvate thereof according to claim 9 wherein R 4 is selected from the group consisting of chloro and fluoro.