IP Library › Granted Patent US 12662513
Granted Patent B2
US 12662513 · App. 16/098,394 · Granted Jun 23, 2026

Peptidic modulators of quorum sensing in

Inventors: Helen E. Blackwell (Middleton, WI); Tian Yang (Madison, WI)
Assignee: Wisconsin Alumni Research Foundation
C07K7/64A61P31/04C07K7/56A61K38/00
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12662513
App. No.
16/098,394
Granted
Jun 23, 2026
Kind
B2
Abstract

Synthetic cyclic peptide modulators of the AgrC quorum sensing system of S. epidermidis. Synthetic agonists and antagonist of AgrC-I are described. Compounds capable of either pan-group or group-selective AgrC receptor inhibition in S. epidermidis were identified. Additionally, compounds that are species selective, and could be applied to selectively modulate either S. epidermidis or S. aureus AgrC receptors were identified. An AgrC-I agonist was found which strongly inhibits S. epidermidis biofilm growth, with a higher potency and efficacy than that of native AIP-I. Methods of modulating virulence in S. epidermidis and related Staphylococcus by contacting a bacterium or a bacterial environment, such as a biofilm, with a modulator of the disclosure are provided. Methods are provided for treating infections of S. epidermidis and related Staphylococcus by administering a therapeutically effective amount of one or more compounds herein to an individual in need thereof.

Claims (29)

1 . A compound which is selected from the peptides of:

 (SEQ ID NO: 176)

K-Y-L-P-(C-S-N-Y-L),

 (SEQ ID NO: 177)

K-Y-V-P-(C-S-N-Y-L),

 (SEQ ID NO: 178)

K-Y-N-V-(C-S-N-Y-L),

 (SEQ ID NO: 179)

K-Y-N-V-(C-A-N-Y-L),

 (SEQ ID NO: 180)

K-Y-N-V-(C-S-A-Y-L),

 (SEQ ID NO: 181)

K-Y-N-V-(C-S-S-Y-L),

 (SEQ ID NO: 94)

A-S-A-(C-A-A-Y-F),

(SEQ ID NO: 95)

A-S-A-(C-S-A-Y-F)

or salts of any thereof.

2 . A method for modulating quorum sensing in S. epidermidis which comprises contacting the bacterium or an environment containing the bacterium with one or more compounds or salts of claim 1 .

3 . A method for inhibiting an AgrC receptor of S. epidermidis or S. aureus which comprises contacting the bacterium or an environment containing the bacterium with one or more compounds or salts of claim 1 .

4 . A pharmaceutical composition for treating Staphylococcus infection which comprises one or more compounds or salts of claim 1 .

5 . The compound of claim 1 which is the peptide:

 (SEQ ID NO: 176)

K-Y-L-P-(C-S-N-Y-L),

 (SEQ ID NO: 94)

A-S-A-(C-A-A-Y-F), 

or

(SEQ ID NO: 95)

A-S-A-(C-S-A-Y-F).