Clear coating antimicrobial compositions, methods of preparation, and uses thereof for conferring antimicrobial activity to a surface
Described herein are clear coating antimicrobial compositions, methods of preparation, and uses thereof for conferring antimicrobial activity to a surface. One particular composition comprises at least one antimicrobial, a vinyl acetal derivative polymer binder and a solvent for solubilizing said at least one antimicrobial and said vinyl acetal derivative polymer binder. Another particular composition, comprises at least one antimicrobial and a binder polymer/solvent selected from an acrylic acid polymer, a polyester-based polymer, an epoxy-based polymer, and mixtures thereof.
1 . A clear coating antimicrobial composition for conferring antimicrobial activity to a hard surface, comprising:
at least one antimicrobial, wherein said least one antimicrobial comprises at least one quaternary ammonium compound, and wherein the composition comprises more than 1% w/w quaternary ammonium compound;
a vinyl acetal derivative polymer binder;
an organic solvent for solubilizing said at least one antimicrobial and said vinyl acetal derivative polymer binder; and
a carrier;
wherein said composition provides durable antimicrobial activity once applied on a hard surface.
2 . The clear coating antimicrobial composition of claim 1 , wherein said organic solvent is selected from the group consisting of polar protic solvent, dipolar aprotic solvent and mixtures thereof.
3 . The clear coating antimicrobial composition of claim 2 , wherein said polar protic solvent is selected from the group consisting of ethanol, n-butanol, methanol, propanol, isopropanol, acetic acid, diacetone alcohol and mixtures thereof.
4 . The clear coating antimicrobial composition of claim 1 , wherein said vinyl acetal derivative polymer binder is selected from the group derived from any aldehyde and polyvinyl alcohol consisting of poly(vinyl butyral) and poly(vinyl formal) and mixtures thereof.
5 . The clear coating antimicrobial composition of claim 1 , wherein the organic solvent comprises at least one alcohol.
6 . The clear coating antimicrobial composition of claim 5 , comprising at least 1% w/w alcohol, or at least 5% w/w alcohol, or at least 10% w/w alcohol, or at least 25% w/w alcohol, or at least 50% w/w alcohol, or at least 60% w/w alcohol, at least 70% w/w alcohol, or at least 75% w/w alcohol, or at least 80% w/w alcohol, or at least 85% w/w alcohol, or at least 90% w/w alcohol, or at least 95% w/w alcohol, or at least 98% w/w alcohol, based on the total weight of the composition.
7 . The clear coating antimicrobial composition of claim 1 , wherein said organic solvent comprises a mixture of ethanol and butanol.
8 . The clear coating antimicrobial composition of claim 7 , wherein said mixture of ethanol and butanol comprises about 70 w/w % to about 98 w/w % ethanol and about 30 w/w % to about 2 w/w % butanol, based on the total weight of the composition.
9 . The clear coating antimicrobial composition of claim 1 , wherein said organic solvent comprises a mixture of ethanol: diacetone alcohol or a mixture of isopropanol: diacetone alcohol.
10 . The clear coating antimicrobial composition of claim 1 , wherein said at least one antimicrobial is selected from the group consisting of quaternary ammonium compounds, metal ion-containing compounds, chelating agents, amino acid-based surfactants, antibiotics, compounds having a guanidine moiety, antifungal agents, antiviral agents and mixtures thereof.
11 . The clear coating antimicrobial composition of claim 1 , wherein the composition comprises 1.1% w/w to about 5% w/w quaternary ammonium compound, based on the total weight of the composition.
12 . The clear coating antimicrobial composition of claim 1 , wherein the carrier is selected from the group consisting of cellulose polymers, acrylic polymers, glycol polymers, polyvinyl alcohols, pyrrolidones and mixtures thereof.
13 . The clear coating antimicrobial composition of claim 12 , wherein the cellulose polymer is selected from the group consisting of hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), hydroxyethylcellulose (HEC), hydroxyethyl methyl cellulose (HEMC), methylcellulose (MC), sodium carboxymethyl cellulose (NaCMC), ethylcellulose (EC), and mixtures thereof.
14 . The clear coating antimicrobial composition of claim 1 , wherein the composition is comprised of 1% w/w to less than 5% w/w of the polymer binder, based on the total weight of the composition.
15 . The clear coating antimicrobial composition of claim 1 , wherein the composition is any one from Formulation as defined in the following table, wherein
R represents the vinyl acetal derivative polymer binder polymer,
R 1 represents the carrier
R 2 represents antimicrobial(s), and
R 3 represent the solvent(s):
Particular examples of clear coating antimicrobial compositions
comprising a vinyl acetal derivative polymer binder
Formulation
Number
R*
R 1 **
R 2 ***
R 3
1
PVB
EC
ADBAC
Ethanol:n-Butanol
2
PVB
EC
ADEBAC
Ethanol:n-Butanol
3
PVB
EC
ADBAC:ADEBAC
Ethanol:n-Butanol
4
PVB
EC
DDAC
Ethanol:n-Butanol
5
PVB
EC
DDAC:ADBAC
Ethanol:n-Butanol
6
PVB
EC
ADBAS
Ethanol:n-Butanol
7
PVB
EC
ADBAC:DDAC
Ethanol:n-Butanol
8
PVB
EC
ADBAC:ADBAS
Ethanol:n-Butanol
9
PVB
EC
ADEBAC:DDAC
Ethanol:n-Butanol
10
PVB
EC
ADEBAC:ADBAS
Ethanol:n-Butanol
11
PVB
EC
ADBAC:ADEBAC:DDAC
Ethanol:n-Butanol
12
PVB
EC
ADBAC:ADEBAC:DDAC:ADBAS
Ethanol:n-Butanol
13
PVB
EC
ADBAC:ODDAC:DODAC:DDDAC
Ethanol:n-Butanol
14
PVB
EC
BC
Ethanol:n-Butanol
15
PVB
EC
HTAC
Ethanol:n-Butanol
16
PVB
EC
DTAB
Ethanol:n-Butanol
17
PVB
EC
TTAB
Ethanol:n-Butanol
21
PVB
EC
ADBAC
2-propanol:n-Butanol
22
PVB
EC
ADEBAC
2-propanol:n-Butanol
23
PVB
EC
ADBAC:ADEBAC
2-propanol:n-Butanol
24
PVB
EC
DDAC
2-propanol:n-Butanol
25
PVB
EC
DDAC:ADBAC
2-propanol:n-Butanol
26
PVB
EC
ADBAS
2-propanol:n-Butanol
26
PVB
EC
ADBAC:DDAC
2-propanol:n-Butanol
27
PVB
EC
ADBAC:ADBAS
2-propanol:n-Butanol
28
PVB
EC
ADEBAC:DDAC
2-propanol:n-Butanol
29
PVB
EC
ADEBAC:ADBAS
2-propanol:n-Butanol
30
PVB
EC
ADBAC:ADEBAC:DDAC
2-propanol:n-Butanol
31
PVB
EC
ADBAC:ADEBAC:DDAC:ADBAS
2-propanol:n-Butanol
32
PVB
EC
ADBAC:ODDAC:DODAC:DDDAC
2-propanol:n-Butanol
33
PVB
EC
BC
2-propanol:n-Butanol
34
PVB
EC
HTAC
2-propanol:n-Butanol
35
PVB
EC
DTAB
2-propanol:n-Butanol
36
PVB
EC
TTAB
2-propanol:n-Butanol
40
PVB
EC
ADBAC
Ethanol:Diacetone
alcohol
41
PVB
EC
ADEBAC
Ethanol:Diacetone
alcohol
42
PVB
EC
ADBAC:ADEBAC
Ethanol:Diacetone
alcohol
43
PVB
EC
DDAC
Ethanol:Diacetone
alcohol
44
PVB
EC
DDAC:ADBAC
Ethanol:Diacetone
alcohol
45
PVB
EC
ADBAS
Ethanol:Diacetone
alcohol
46
PVB
EC
ADBAC:DDAC
Ethanol:Diacetone
alcohol
47
PVB
EC
ADBAC:ADBAS
Ethanol:Diacetone
alcohol
48
PVB
EC
ADEBAC:DDAC
Ethanol:Diacetone
alcohol
49
PVB
EC
ADEBAC:ADBAS
Ethanol:Diacetone
alcohol
50
PVB
EC
ADBAC:ADEBAC:DDAC
Ethanol:Diacetone
alcohol
51
PVB
EC
ADBAC:ADEBAC:DDAC:ADBAS
Ethanol:Diacetone
alcohol
52
PVB
EC
ADBAC:ODDAC:DODAC:DDDAC
Ethanol:Diacetone
alcohol
53
PVB
EC
BC
Ethanol:Diacetone
alcohol
54
PVB
EC
HTAC
Ethanol:Diacetone
alcohol
55
PVB
EC
DTAB
Ethanol:Diacetone
alcohol
56
PVB
EC
TTAB
Ethanol:Diacetone
alcohol
60
PVB
EC
ADBAC
2-propanol:Diacetone
alcohol
61
PVB
EC
ADEBAC
2-propanol:Diacetone
alcohol
62
PVB
EC
ADBAC:ADEBAC
2-propanol:Diacetone
alcohol
63
PVB
EC
DDAC
2-propanol:Diacetone
alcohol
64
PVB
EC
DDAC:ADBAC
2-propanol:Diacetone
alcohol
65
PVB
EC
ADBAS
2-propanol:Diacetone
alcohol
66
PVB
EC
ADBAC:DDAC
2-propanol:Diacetone
alcohol
67
PVB
EC
ADBAC:ADBAS
2-propanol:Diacetone
alcohol
68
PVB
EC
ADEBAC:DDAC
2-propanol:Diacetone
alcohol
69
PVB
EC
ADEBAC:ADBAS
2-propanol:Diacetone
alcohol
70
PVB
EC
ADBAC:ADEBAC:DDAC
2-propanol:Diacetone
alcohol
71
PVB
EC
ADBAC:ADEBAC:DDAC:ADBAS
2-propanol:Diacetone
alcohol
72
PVB
EC
ADBAC:ODDAC:DODAC:DDDAC
2-propanol:Diacetone
alcohol
73
PVB
EC
BC
2-propanol:Diacetone
alcohol
74
PVB
EC
HTAC
2-propanol:Diacetone
alcohol
75
PVB
EC
DTAB
2-propanol:Diacetone
alcohol
76
PVB
EC
TTAB
2-propanol:Diacetone
alcohol
80
PVB
EC
ADBAC
Ethanol
81
PVB
EC
ADEBAC
Ethanol
82
PVB
EC
ADBAC:ADEBAC
Ethanol
83
PVB
EC
DDAC
Ethanol
84
PVB
EC
DDAC:ADBAC
Ethanol
85
PVB
EC
ADBAS
Ethanol
86
PVB
EC
ADBAC:DDAC
Ethanol
87
PVB
EC
ADBAC:ADBAS
Ethanol
88
PVB
EC
ADEBAC:DDAC
Ethanol
89
PVB
EC
ADEBAC:ADBAS
Ethanol
90
PVB
EC
ADBAC:ADEBAC:DDAC
Ethanol
91
PVB
EC
ADBAC:ADEBAC:DDAC:ADBAS
Ethanol
92
PVB
EC
ADBAC:ODDAC:DODAC:DDDAC
Ethanol
93
PVB
EC
BC
Ethanol
94
PVB
EC
HTAC
Ethanol
95
PVB
EC
DTAB
Ethanol
96
PVB
EC
TTAB
Ethanol
100
PVB
EC
ADBAC
2-propanol
101
PVB
EC
ADEBAC
2-propanol
102
PVB
EC
ADBAC:ADEBAC
2-propanol
103
PVB
EC
DDAC
2-propanol
104
PVB
EC
DDAC:ADBAC
2-propanol
105
PVB
EC
ADBAS
2-propanol
106
PVB
EC
ADBAC:DDAC
2-propanol
107
PVB
EC
ADBAC:ADBAS
2-propanol
108
PVB
EC
ADEBAC:DDAC
2-propanol
109
PVB
EC
ADEBAC:ADBAS
2-propanol
110
PVB
EC
ADBAC:ADEBAC:DDAC
2-propanol
111
PVB
EC
ADBAC:ADEBAC:DDAC:ADBAS
2-propanol
112
PVB
EC
ADBAC:ODDAC:DODAC:DDDAC
2-propanol
113
PVB
EC
BC
2-propanol
114
PVB
EC
HTAC
2-propanol
115
PVB
EC
DTAB
2-propanol
116
PVB
EC
TTAB
2-propanol
120
PVB
EC
ADBAC
n-Butanol
121
PVB
EC
ADEBAC
n-Butanol
122
PVB
EC
ADBAC:ADEBAC
n-Butanol
123
PVB
EC
DDAC
n-Butanol
124
PVB
EC
DDAC:ADBAC
n-Butanol
125
PVB
EC
ADBAS
n-Butanol
126
PVB
EC
ADBAC:DDAC
n-Butanol
127
PVB
EC
ADBAC:ADBAS
n-Butanol
128
PVB
EC
ADEBAC:DDAC
n-Butanol
129
PVB
EC
ADEBAC:ADBAS
n-Butanol
130
PVB
EC
ADBAC:ADEBAC:DDAC
n-Butanol
131
PVB
EC
ADBAC:ADEBAC:DDAC:ADBAS
n-Butanol
132
PVB
EC
ADBAC:ODDAC:DODAC:DDDAC
n-Butanol
133
PVB
EC
BC
n-Butanol
134
PVB
EC
HTAC
n-Butanol
135
PVB
EC
DTAB
n-Butanol
136
PVB
EC
TTAB
n-Butanol
140
PVB
EC
ADBAC
Diacetone alcohol
141
PVB
EC
ADEBAC
Diacetone alcohol
142
PVB
EC
ADBAC:ADEBAC
Diacetone alcohol
143
PVB
EC
DDAC
Diacetone alcohol
144
PVB
EC
DDAC:ADBAC
Diacetone alcohol
145
PVB
EC
ADBAS
Diacetone alcohol
146
PVB
EC
ADBAC:DDAC
Diacetone alcohol
147
PVB
EC
ADBAC:ADBAS
Diacetone alcohol
147
PVB
EC
ADEBAC:DDAC
Diacetone alcohol
148
PVB
EC
ADEBAC:ADBAS
Diacetone alcohol
149
PVB
EC
ADBAC:ADEBAC:DDAC
Diacetone alcohol
150
PVB
EC
ADBAC:ADEBAC:DDAC:ADBAS
Diacetone alcohol
151
PVB
EC
ADBAC:ODDAC:DODAC:DDDAC
Diacetone alcohol
152
PVB
EC
BC
Diacetone alcohol
153
PVB
EC
HTAC
Diacetone alcohol
154
PVB
EC
DTAB
Diacetone alcohol
155
PVB
EC
TTAB
Diacetone alcohol
*PVB = Polyvinylbutyral;
**EC = Ethyl cellulose;
***ADBAC = N-alkyl dimethyl benzyl ammonium chloride; ADEBAC = N-alkyl dimethyl ethylbenzyl ammonium chloride; DDAC = Didecyl dimethyl ammonium chloride; ADBAS = N-alkyl dimethyl benzyl ammonium saccharinate; ODDAC = Octyl decyl dimethyl ammonium chloride; DODAC = Dooctyl dimethyl ammonium chloride; DDDAC = Didecyl dimethyl ammonium chloride; BC = Benzethonium chloride; HTAC = Hexadecyl trimethyl ammonium chloride; DTAB = Decyl trimethyl ammonium bromide; TTAB = Tetra trimethyl ammonium bromide.
16 . The clear coating antimicrobial composition of claim 1 , further comprising an additive, wherein the additive enhances any of the following properties of the composition or final coating derived therefrom: preservation properties, mechanical properties, thermal properties, electrical properties, barrier properties, rheology properties, scavenging properties, exfoliation properties, fire-retardant properties, permeability properties, surfactant properties, rust-proofing properties, olfactive properties, wetting properties, drying properties, adhesion properties and levelling properties.
17 . The clear coating antimicrobial composition of claim 1 , wherein the composition consists essentially of polyvinyl butyral (PVB), ethylcellulose and quaternary ammonium(s) dispersed into ethanol and n-butanol.
18 . The clear coating antimicrobial composition of claim 1 , wherein the composition consists essentially of polyvinyl butyral (PVB), ethylcellulose and N-alkyl dimethyl benzyl ammonium chloride (ADBAC) dispersed in ethanol and butanol.
19 . A clear coating antimicrobial composition for conferring antimicrobial activity to a hard surface, comprising:
(i) N-alkyl dimethyl benzyl ammonium chloride (ADBAC);
(ii) polyvinylbutyral (PVB);
(iii) a carrier;
(iv) a solvent for solubilizing said (i) and (ii), wherein said solvent comprises a mixture of ethanol and butanol; and
(v) ethylcellulose (EC).
20 . An article of manufacture comprising the clear coating antimicrobial composition as defined in claim 1 , wherein said article is selected from the group consisting of plastics, polymers, steel, glass, wood, ceramic, concrete, walls, paper, cellulose, foams, fibers, filters, and leather.
21 . A method for conferring antimicrobial activity to a hard surface, comprising contacting said surface with the clear coating antimicrobial composition as defined in claim 1 .
22 . The method of claim 21 , comprising spraying or brushing the hard surface with said clear coating antimicrobial composition, and wherein said hard surface is selected from the group consisting of furniture, partition curtains, handrails, doors, doorknobs, medical equipment, walls, floors, elevators, air vents, air filters.
23 . The clear coating antimicrobial composition of claim 1 , wherein the at least one quaternary ammonium compound is selected from the group consisting of: akyl dimethyl benzyl ammonium chloride (ADBAC), didecyl dimethyl ammonium chloride (DDAC), benzyldimethyl(2-dodecyloxyethyl)-ammonium chloride, benzyldimethyl(2-hydroxyethyl)ammonium chloride, benzyldimethyl (hexadecylcarbamoylmethyl)ammonium chloride, benzyldimethyl (tetradecylcarboamoylmethyl)ammonium chloride, benzyloxycarbonylmethyl-trimethylammonium chloride, bis-(2-hydroxyethyl)-ciannamyl(2-dodecyloxymethyl)ammonium chloride, benzyltriethylammonium chloride, tetramethylammonium chloride, tetramethylammonium iodide, tetraethylammonium hydroxide, tetramethylammonium hydroxide, benzyltrimethylammonium hydroxide, dimethyldioctadecylammonium chloride, dodecyltrimethylammonium choride, trimethylphenylammonium chloride, octadecyltrimethyl ammonium bromide, tetrabutyl ammonium bromide, tetramethylammonium nitrate, tetrabutylammonium hydroxide, didodecyldimethyl ammonium bromide, didodecyldimethylammonium chloride, dimethyldioctadecyl ammonium bromide, (2-(methacryloyloxy)ethyl)trimethylammonium chloride, dioctyl dimethyl ammonium chloride, tetrapropylammonium chloride, didecyldimethylammonium chloride, bezyldodecyldimethyl ammonium bromide, diallyl dimethyl ammonium chloride, benzalkonium bromide, ammonium bromide, benzyltributylammonium chloride, octyldecyl dimethyl ammonium chloride, tetrabutylammonium hydrogen sulfate, tetrabutylammonium tribromide, methyltributylammonium chloride, bis(hydrogenated tallow)dimethylammonium chloride, N-alkyldimethyl benzyl ammonium chloride, and tetrabutylammonium fluoride trihydrate and mixtures thereof.
24 . A clear coating antimicrobial composition for conferring antimicrobial activity to a hard surface, comprising:
at least one antimicrobial, wherein said least one antimicrobial comprises at least one quaternary ammonium compound;
a vinyl acetal derivative polymer binder;
an organic solvent for solubilizing said at least one antimicrobial and said vinyl acetal derivative polymer binder; and
a carrier;
wherein the at least one quaternary ammonium compound is selected from the group consisting of: akyl dimethyl benzyl ammonium chloride (ADBAC), didecyl dimethyl ammonium chloride (DDAC), benzyldimethyl(2-dodecyloxyethyl)-ammonium chloride, benzyldimethyl(2-hydroxyethyl)ammonium chloride, benzyldimethyl (hexadecylcarbamoylmethyl)ammonium chloride, benzyldimethyl (tetradecylcarboamoylmethyl)ammonium chloride, benzyloxycarbonylmethyl-trimethylammonium chloride, bis-(2-hydroxyethyl)-ciannamyl(2-dodecyloxymethyl)ammonium chloride, benzyltriethylammonium chloride, tetramethylammonium chloride, tetramethylammonium iodide, tetraethylammonium hydroxide, tetramethylammonium hydroxide, benzyltrimethylammonium hydroxide, dimethyldioctadecylammonium chloride, dodecyltrimethylammonium choride, trimethylphenylammonium chloride, octadecyltrimethyl ammonium bromide, tetrabutyl ammonium bromide, tetramethylammonium nitrate, tetrabutylammonium hydroxide, didodecyldimethyl ammonium bromide, didodecyldimethylammonium chloride, dimethyldioctadecyl ammonium bromide, (2-(methacryloyloxy)ethyl)trimethylammonium chloride, dioctyl dimethyl ammonium chloride, tetrapropylammonium chloride, didecyldimethylammonium chloride, bezyldodecyldimethyl ammonium bromide, diallyl dimethyl ammonium chloride, benzalkonium bromide, ammonium bromide, benzyltributylammonium chloride, octyldecyl dimethyl ammonium chloride, tetrabutylammonium hydrogen sulfate, tetrabutylammonium tribromide, methyltributylammonium chloride, bis(hydrogenated tallow)dimethylammonium chloride, N-alkyldimethyl benzyl ammonium chloride, and tetrabutylammonium fluoride trihydrate and mixtures thereof; and
wherein said composition provides durable antimicrobial activity once applied on a hard surface.