Automated library preparation system
An automated library preparation system ( 1 ) includes a consumable item storage module ( 10 ) for storing a consumable item; a dispatching transfer module ( 30 ) capable of moving along a predetermined direction; a biochemical reaction module ( 20 ) including a plurality of biochemical reaction devices ( 21 a, 21 b ) which are arranged in turn along the predetermined direction, each of the plurality of biochemical reaction devices being configured to perform one subprocess of sample preparation for gene sequencing, the dispatching transfer module ( 30 ) being configured to grab the consumable item ( 2 ) stored in the consumable item storage module, the dispatching transfer module being further configured to transfer the consumable item to the plurality of biochemical reaction devices when sliding along the predetermined direction; and a control module configured to control the consumable item storage module, the biochemical reaction module, and the dispatching transfer module to work collaboratively.
1 . An automated library preparation system, comprising:
a plurality of consumable item storage devices configured for storing a consumable item;
at least two dispatching transfer devices movable in a first direction; and
a plurality of biochemical reaction devices which are spaced apart in the first direction, each of the plurality of biochemical reaction devices being configured to perform one subprocess of sample preparation for gene sequencing, wherein each of the at least two dispatching transfer devices is configured to grab a consumable item stored in a corresponding consumable item storage device of the plurality of consumable item storage devices, each of the at least two dispatching transfer devices is further configured to transfer a consumable item to the plurality of biochemical reaction devices as the at least two dispatching transfer devices sliding in the first direction;
each of the plurality of consumable item storage devices comprises a storage rack for storing a consumable item, a discharging support plate, a discharging manipulator, a horizontal guide rail, and a vertical guide rail, the discharging manipulator is slidably disposed on the horizontal guide rail and the vertical guide rail and is configured to clamp a storage item in the storage rack and transfer the clamped consumable item to the discharging support plate;
each of the at least two dispatching transfer devices comprises a dispatching transfer assembly, the dispatching transfer assembly comprises a dispatching manipulator, a consumable item buffer plate arranged at a first end of the dispatching manipulator, and a clamping jaw arranged at a second end of dispatching manipulator, and the dispatching manipulator is configured to drive the clamping jaw to clamp a consumable item on the discharging support plate and transfer clamped consumable item to the consumable buffer plate.
2 . The automated library preparation system of claim 1 , wherein the automated library preparation system comprises at least two processing areas which are separated from each other, each of the at least two processing areas encloses a closed chamber, the at least two processing areas are arranged in the first direction, at least one of the plurality of biochemical reaction devices is located in each of the at least two processing areas.
3 . The automated library preparation system of claim 2 , wherein a transfer window device is arranged between two adjacent processing areas of the at least two processing areas, the transfer window is configured to maintain separation between the two adjacent processing areas when one of the at least two dispatching transfer devices transfers a consumable item from one of the two adjacent processing areas of the plurality of processing areas to the other of the two adjacent processing areas of the plurality of processing areas, the transfer window device comprises a front automatic door and a rear automatic door, when one of the at least two dispatching transfer devices transfers a consumable item from one of the two adjacent processing areas of the plurality of processing areas to the other of the two adjacent processing areas of the plurality of processing areas, one of the front automatic door and the rear automatic door is opened, and the other of the front automatic door and the rear automatic door is closed to maintain separation between the two adjacent processing areas.
4 . The automated library preparation system of claim 3 , wherein the transfer window device further comprises a separating block the front automatic door is disposed on a first side of the separating block, the rear automatic door is disposed on a second side of the separating block which is opposite to the first side of the separating block, the separating block defines a consumable item accommodation chamber, the consumable item accommodation chamber is configured to accommodate a consumable item transferred from one of the two adjacent processing areas of the plurality of processing areas, the front automatic door and the rear automatic door are configured to close opposite sides of the consumable item accommodation chamber when the front automatic door and the rear automatic door are closed.
5 . The automated library preparation system of claim 2 , wherein the plurality of consumable item storage devices are respectively located in the at least two processing areas, one of the plurality of consumable item storage devices in a corresponding processing area of the at least two processing areas is configured to provide a consumable item for a corresponding biochemical reaction device of the plurality of the biochemical reaction devices in the corresponding processing area.
6 . The automated library preparation system of claim 5 , wherein corresponding consumable item storage devices of the plurality of consumable item storage devices in one of the at least two processing areas comprises a normal temperature type consumable item storage device and a low-temperature type consumable item storage device, the normal temperature type consumable item storage device is configured to provide a room temperature storage environment for storing a consumable item, the low-temperature type consumable item storage device is configured to provide a low-temperature storage environment for storing a consumable item.
7 . The automated library preparation system of claim 5 , wherein the at least two dispatching transfer devices are respectively disposed in each of the two processing areas, each of the at least two dispatching transfer devices comprises a slide rail extending in the first direction, the dispatching transfer assembly is slidably arranged on the slide rail.
8 . The automated library preparation system of claim 1 , further comprising a film sealing device and a film peeling device, the film sealing device being configured to apply a packaging film on a consumable item, the film peeling device being configured to remove the packaging film on a consumable item.
9 . The automated library preparation system of claim 1 , further comprising a centrifuge device, the centrifuge device being configured to centrifugally process liquid in a consumable item.