Systems and methods for multistage mass spectrometry utilizing an electrostatic ion trap
Systems and methods are disclosed for ion injection into an electrostatic trap. Various aspects of this disclosure provide a mass spectrometer system including a primary ion path including a plurality of quadrupoles; and a secondary ion path coupled to the primary ion path utilizing turning elements. The secondary ion path may include an electrostatic linear ion trap (ELIT), the ELIT being operable to analyze ions diverted from the primary ion path and return them to the primary ion path. The primary ion path may include a time-of-flight mass analyzer. The secondary ion path may be bi-directional. Ions may travel in a first direction when coupled into the secondary ion path using a first turning element in the primary ion path and may travel in a second direction when coupled into the secondary ion path utilizing a second turning element in the primary ion path. The secondary ion path may include a collision quadrupole.
1 . A mass spectrometer system comprising:
a primary ion path comprising a plurality of quadrupoles comprising Q 0 , Q 1 , Q 2 , Q 3 , and Q 4 ; and
a secondary ion path coupled to the primary ion path utilizing turning elements, wherein the secondary ion path comprises an electrostatic linear ion trap (ELIT), the ELIT being operable to analyze ions diverted from the primary ion path and return them to the primary ion path, wherein the turning elements comprise a first turning element and a second turning element, wherein the first turning element is arranged between Q 1 and Q 2 and the second turning element is arranged between Q 3 and Q 4 .
2 . The mass spectrometer system according to claim 1 , wherein the primary ion path comprises a time-of-flight mass analyzer.
3 . The mass spectrometer system according to claim 1 , wherein the secondary ion path is bi-directional.
4 . The mass spectrometer system according to claim 1 , wherein ions travel in a first direction when coupled into the secondary ion path using a first turning element in the primary ion path and travel in a second direction when coupled into the secondary ion path utilizing a second turning element in the primary ion path.
5 . The mass spectrometer system according to claim 1 , wherein the secondary ion path comprises a collision quadrupole.
6 . The mass spectrometer system according to claim 1 , wherein the secondary ion path comprises an accumulation quadrupole.
7 . The mass spectrometer system according to claim 1 , wherein the secondary ion path comprises an injection quadrupole operable to inject ions into the ELIT.
8 . The mass spectrometer system according to claim 1 , wherein one of the plurality of quadrupoles in the primary ion path comprises a bent quadrupole.
9 . The mass spectrometer system according to claim 1 , wherein the secondary ion path is operable to cycle ions multiple times before analyzing the ions in the ELIT.
10 . The mass spectrometer system according to claim 1 , wherein the primary ion path comprises a detector for analyzing ions after passing through the secondary ion path one or more times.
11 . A method for mass spectrometry, the method comprising:
in a mass spectrometry system comprising a primary ion path comprising a plurality of quadrupoles comprising Q 0 , Q 1 , Q 2 , Q 3 , and Q 4 , and a secondary ion path coupled to the primary ion path utilizing turning elements:
analyzing, using an electrostatic linear ion trap (ELIT) in the secondary ion path, ions diverted from the primary ion path unto the secondary ion path by a first turning element; and
returning the ions to the primary ion path using a second turning element, wherein the first turning element is arranged between Q 1 and Q 2 and the second turning element is arranged between Q 3 and Q 4 .
12 . The method according to claim 11 , wherein the primary ion path comprises a time-of-flight mass analyzer.
13 . The method according to claim 11 , wherein the secondary ion path is bi-directional.
14 . The method according to claim 11 , comprising directing ions to travel in a first direction when coupled into the secondary ion path using a first turning element in the primary ion path and directing ions to travel in a second direction when coupled into the secondary ion path utilizing a second turning element in the primary ion path.
15 . The method according to claim 11 , wherein the secondary ion path comprises a collision quadrupole.
16 . The method according to claim 11 , wherein the secondary ion path comprises an accumulation quadrupole.
17 . The method according to claim 11 , comprising injecting ions into the ELIT using an injection quadrupole in the secondary ion path.
18 . The method according to claim 11 , wherein one of the plurality of quadrupoles in the primary ion path comprises a bent quadrupole.
19 . The method according to claim 11 , comprising cycling ions multiple times through the secondary ion path before analyzing the ions in the ELIT.
20 . The method according to claim 11 , comprising analyzing ions using a detector in the primary ion path after passing through the secondary ion path one or more times.