Taste-modulation of cooling agents in beverages
View Patent ↗A beverage is a drinkable liquid. Described here is a beverage containing a cooling agent that will exert cooling sensations in the upper center of the chest and make a subject feel comfortable. The cooling agent is an agent that targets TRPM8 receptors on nerve cell membranes. The beverage can be imbibed without unpleasant taste and the goal is to make the whole body feel cooler for about 20 min or more after drinking. By choosing the right molecule and right concentration, cooling intensity, location, and duration in the chest is controlled. Surprisingly, the cooling agent was also effective when consumed with warm or hot beverages. The beverage contains selected 1-diisopropyl-phosphinoyl-alkanes and taste-modulating agents selected from sweeteners, extracts from hops, ginger, or cinchona. Various uses of this cooling beverage are proposed.
1 . A beverage comprising: a liquid, a 1-diisopropyl-phosphinoyl-nonane (DIPA-1-9), and neotame, wherein the neotame is present in the beverage at a concentration of 0.05 to 0.2 mg/mL.
2 . The beverage of claim 1 wherein 1-diisopropyl-phosphinoyl-nonane (DIPA-1-9) is present in the beverage at a concentration of 0.01 to 1.0 mg/mL.