Medication monitoring based on local field potential
A method for determining an efficacy of medication treatment for a patient includes determining, by one or more processors, based on a local field potential (LFP) activity of the patient, when the patient takes medication and/or a duration of when the medication is effective. The method further includes outputting, by the one or more processors, an indication of when the patient takes the medication and/or the duration of when the medication is effective to facilitate a treatment for the patient.
1 . A method for determining an efficacy of medication treatment for a patient, the method comprising:
generating, by one or more processors and based on processing one or more bioelectric signals sensed from the patient, an indication of a local field potential (LFP) activity of the patient;
determining, by the one or more processors, at least one of:
when the patient takes medication based on a decrease of a magnitude of the LFP activity of the patient; or
a duration of when the medication is effective based on a duration during which the magnitude of the LFP activity of the patient satisfies a range of LFP values; and
outputting, by the one or more processors, at least one of an indication of when the patient takes the medication or the duration of when the medication is effective to facilitate a treatment for the patient.
2 . The method of claim 1 , wherein determining the duration of when the medication is effective comprises:
determining, based on the LFP activity of the patient and after the patient takes the medication, when the medication is effective for treatment of the patient;
determining, based on the LFP activity of the patient and after the medication is effective for treatment of the patient, when the medication is not effective for treatment of the patient; and
determining the duration of when the medication is effective based on when the medication is effective for treatment of the patient and when the medication is not effective for treatment of the patient.
3 . The method of claim 2 , further comprising:
outputting, by the one or more processors, an instruction to request a user input to confirm that the medication is not currently effective for treatment of the patient in response to determining that the medication is not effective for treatment of the patient;
determining, by the one or more processors, whether the user input responsive to the request indicates that the medication is not effective for treatment of the patient; and
storing, by the one or more processors, an indication of whether the user input responsive to the request indicates that the medication is not effective for treatment of the patient and an indication of the LFP activity of the patient during the duration of when the medication is effective.
4 . The method of claim 1 , wherein the duration during which the magnitude of the LFP activity of the patient satisfies the range of LFP values comprises a duration during which the magnitude of the LFP activity of the patient is within the range of LFP values.
5 . The method of claim 1 , further comprising determining when the medication is not effective for treatment of the patient based on determining that the magnitude of the LFP activity of the patient does not satisfy the range of LFP values.
6 . The method of claim 5 , wherein determining that the magnitude of the LFP activity of the patient does not satisfy the range of LFP values comprises determining that the magnitude of the LFP activity of the patient is outside of the range of LFP values.
7 . The method of claim 1 , further comprising receiving, by the one or more processors, an indication of the range of LFP values.
8 . The method of claim 1 , further comprising receiving, by the one or more processors, an indication of when the patient takes the medication.
9 . The method of claim 1 , further comprising:
determining, by the one or more processors, based on the LFP activity of the patient and after the patient takes the medication, that the patient is overmedicated by the medication; and
outputting, by the one or more processors, an indication that the patient is overmedicated by the medication in response to determining that the patient is overmedicated.
10 . The method of claim 1 , further comprising:
sensing, by the one or more processors, the one or more bioelectric signals of brain of the patient, wherein the one or more bioelectric signals comprise the LFP activity of the patient; and
applying, by the one or more processors, electrical stimulation therapy based on the one or more bioelectric signals of the brain of the patient.
11 . The method of claim 1 , further comprising determining, based on the LFP activity of the patient, whether the medication is more effective than another medication.
12 . The method of claim 1 , further comprising determining, based on the duration of when the medication is effective, whether the medication is more effective than another medication.
13 . The method of claim 1 , further comprising determining, based on the LFP activity of the patient, whether a combination of the medication and a first stimulation is more effective than another combination of a second medication and a second stimulation.
14 . The method of claim 1 , further comprising determining, based on the duration of when the medication is effective, whether a combination of the medication and a first stimulation is more effective than another combination of a second medication and a second stimulation.
15 . The method of claim 1 , further comprising comparing the duration of when the medication is effective to a baseline duration of when the medication is effective.
16 . The method of claim 1 , further comprising modifying a stimulation for the patient based on one or more of the LFP activity of the patient or the duration of when the medication is effective.
17 . A system for providing stimulation to a patient, the system comprising:
sensing circuitry configured to sense one or more bioelectric signals from a patient; and
processing circuitry configured to:
generate, based on processing the one or more bioelectric signals sensed from the patient, an indication of a local field potential (LFP) activity of the patient;
determine, based on the LFP activity of the patient, at least one of:
when the patient takes medication based on a decrease of a magnitude of the LFP activity of the patient; or
a duration of when the medication is effective based on a duration during which the magnitude of the LFP activity of the patient satisfies a range of LFP values; and
output at least one of an indication of when the patient takes the medication or the duration of when the medication is effective to facilitate a treatment for the patient.
18 . A non-transitory computer-readable storage medium having stored thereon instructions that, when executed, cause processing circuitry to:
generate, based on processing one or more bioelectric signals sensed from a patient, an indication of a local field potential (LFP) activity of the patient;
determine, based on the LFP activity of the patient, at least one of:
when the patient takes medication based on a decrease of a magnitude of the LFP activity of the patient; or
a duration of when the medication is effective based on a duration during which the magnitude of the LFP activity of the patient satisfies a range of LFP values; and
output at least one of an indication of when the patient takes the medication or the duration of when the medication is effective to facilitate a treatment for the patient.