System and method for urodynamic analysis using ultrasound data
Methods and systems for ultrasound-based urodynamic evaluation are presented in the present disclosure. Pre-void and post-void ultrasound data of a bladder is acquired, in addition to a dynamic acquisition during voiding on a sagittal plane that encompasses the bladder, bladder neck and proximal urethra. The dynamic acquisition may be an ultrasound cine scan or a uroflowmetry measurement during voiding. Using semiautomatic segmentation, the volumes are quantified and virtual models are generated. Similarly, the ultrasound cine sagittal images are segmented to determine the deformation pattern of the bladder during voiding. Using an algorithm, a volume interpolation between pre and post void volumes is performed using the deformation profile obtained from the dynamic sagittal images as a constraint. Resolved bladder volumes are then analyzed using a computational fluid dynamics algorithm to derive flow rates and pressures and to calculate indices of contractility (BCI) and bladder obstruction (BOOI).
1 . A method for urodynamic evaluation during voiding of a bladder, the method comprising:
receiving an ultrasound cine scan of a voiding event of a bladder of a subject, wherein the ultrasound cine scan includes images of a first bladder volume before the voiding event, of a second bladder volume after the voiding event, and of the voiding event between the first bladder volume and second bladder volume;
segmenting the images of the first bladder volume and the image of the second bladder volume to determine the first bladder volume and the second bladder volume;
generating a three-dimensional (3D) virtual model of the bladder from each of the first bladder volume and the second bladder volume;
deriving flow information during the voiding event;
generating a flow curve from the flow information;
inputting the 3D virtual model and the flow curve into a computational fluid dynamics (CFD) model; and
generating a report using the inputs of the CFD model.
2 . The method of claim 1 , wherein the first bladder volume is greater than the second bladder volume.
3 . The method of claim 2 , wherein the first bladder volume is at a maximum bladder volume and the second bladder volume is at a minimum bladder volume.
4 . The method of claim 1 , wherein the 3D virtual model is registered to a spherical coordinate system.
5 . The method of claim 1 , wherein deriving the flow information during the voiding event includes segmenting the images to determine a deformation of the bladder.
6 . The method of claim 5 , further comprising defining a series of structural elements across a segmented bladder in the images of the first bladder volume, the second bladder volume, and during the voiding event.
7 . The method of claim 6 , wherein the structural elements are triangles and further comprising enforcing a consistent number of triangles across the image of the first bladder volume, the second bladder volume, and the voiding event, while preserving a shape of the bladder.
8 . The method of claim 7 , further comprising determining at least one of bladder capacity, voiding pressure, flow dynamics, pressure at maximum flow, post voiding residual volume, emptying efficiency, or maximum flow to determine one or more metrics describing function of a urinary tract during voiding.
9 . The method of claim 8 , comprising producing at least one of the images with functional overlays, graphs showing the one or more metrics over time, or metric-correlated indices including at least one of bladder outlet obstruction index (BOOI) or bladder contractility index (BCI).
10 . The method of claim 1 , further comprising receiving a uroflowmetry acquisition during the voiding event.
11 . The method of claim 10 , wherein the uroflowmetry acquisition generates an output including at least one of a urine voiding volume, a urine voiding speed, and a total urine voiding time.
12 . The method of claim 11 , wherein the CFD model receives the output.
13 . The method of claim 1 , wherein the ultrasound cine scan is performed while the subject is in an upright or seated position.
14 . An ultrasound imaging system comprising:
a transducer configured to transmit an ultrasound signal to a region of interest including a bladder of a subject during a voiding event and receive a reflected ultrasound signal from the region of interest;
a processor coupled to the transducer and configured to:
receive the reflected ultrasound signal;
generate a plurality of images from the received signal of the region of interest during the voiding event;
segment a first image of the region of interest to determine a first bladder volume and a second image of the region of interest to determine a second bladder volume;
generate a three-dimensional (3D) virtual model of the bladder from each of the first bladder volume and the second bladder volume;
derive flow information during the voiding event;
generate a flow curve from the flow information;
input the 3D virtual model and the flow curve into a computational fluid dynamics (CFD) model; and
generate a report using the inputs of the CFD model.
15 . The system of claim 14 , wherein the first bladder volume is greater than the second bladder volume.
16 . The system of claim 15 , wherein the first bladder volume is at a maximum bladder volume and the second bladder volume is at a minimum.
17 . The system of claim 14 , wherein the 3D virtual model is registered to a spherical coordinate system.
18 . The system of claim 14 , wherein deriving the flow information during the voiding event includes segmenting the plurality of images to determine a deformation of the bladder.
19 . The system of claim 18 , wherein the processor is further configured to define a series of structural elements across a segmented bladder in each of the images of the first bladder volume, the second bladder volume, and the voiding event.
20 . The system of claim 19 , wherein the structural elements are triangles, and the processor is further configured to enforce a consistent number of triangles across the image of the first bladder volume, the image of the second bladder volume, and the plurality of images during the voiding event, while preserving a shape of the bladder.
21 . The system of claim 20 , wherein the processor is further configured to determine at least one of bladder capacity, voiding pressure, flow dynamics, pressure at maximum flow, post voiding residual volume, emptying efficiency, or maximum flow to determine one or more metrics describing function of a urinary tract during voiding.
22 . The system of claim 21 , wherein the processor is further configured to produce at least one of images with functional overlays, graphs showing the one or more metrics over time, or metric-correlated indices including at least one of bladder outlet obstruction index (BOOI) or bladder contractility index (BCI).
23 . The system of claim 14 , wherein the processor is further configured to receive uroflowmetry acquisition during the voiding event.
24 . The system of claim 23 , wherein the uroflowmetry acquisition generates an output including at least one of a urine voiding volume, a urine voiding speed, and a total urine voiding time.
25 . The system of claim 24 , wherein the CFD model receives the output.
26 . The system of claim 14 , wherein the ultrasound signal is transmitted and received from the region of interest while the subject is in an upright or seated position.