High-pressure embolic material delivery device and related technology
An embolic material delivery device in accordance with at least some embodiments of the present technology achieves a high pressure rating with a small wall thickness. The device includes an elongate conduit body configured to extend intravascularly toward a treatment location including an aneurysm. The conduit body defines an axial lumen through which viscous embolic material is conveyed toward the aneurysm while at least a portion of the liquid embolic material is at very high pressure (e.g., 9,000 psi or greater). The conduit body includes a metal hypotube coaxially disposed around the axial lumen. The hypotube includes cuts configured to increase a flexibility of the conduit body and bridges between the cuts. The conduit body further includes an elastomeric jacket extending around at least a portion of the hypotube. An average wall thickness of the conduit body is within a range of 0.005 to 0.007 inches.
1 . An embolic material delivery device, comprising:
a conduit body configured to extend intravascularly toward a treatment location, wherein the conduit body is elongate, defines an axial lumen, and comprises:
a proximal end portion,
a distal end portion opposite to the proximal end portion along a length of the conduit body, wherein the axial lumen extends between the proximal and distal end portions of the conduit body along a longitudinal axis of the conduit body,
a hypotube comprising an outer surface and an inner surface coaxially disposed around the axial lumen, wherein the hypotube defines a wall thickness between the outer surface and the inner surface, wherein the hypotube defines a plurality of cuts and a plurality of bridges, each bridge interspersed between a respective pair of cuts, wherein the plurality of cuts and the plurality of bridges are circumferentially disposed along a plurality of circumferential turns extending along the length of the conduit body, wherein each bridge has a respective bridge length along at least one of the plurality of circumferential turns between the respective pair of cuts, wherein the plurality of cuts extend through the wall thickness with each cut extending at least partially circumferentially around the hypotube along a respective cut axis, wherein an angle between the cut axis and the longitudinal axis is progressively less orthogonal from the distal end portion of the conduit body to the proximal end portion of the conduit body, and wherein the bridge length increases as the angle decreases, and
a jacket extending around at least a portion of the outer surface of the hypotube and covering the plurality of cuts,
wherein the conduit body is configured to convey liquid embolic material toward the treatment location via the axial lumen while at least a portion of the liquid embolic material is at a pressure of 9,000 psi or greater, and
wherein the jacket is configured to fluidically seal the plurality of cuts such that at least a portion of the conduit body is configured to withstand the pressure of 9,000 psi or greater.
2 . The embolic material delivery device of claim 1 , wherein the plurality of cuts comprise a plurality of slots, each slot comprising one or more sidewalls defined by the wall thickness of the hypotube.
3 . The embolic material delivery device of claim 1 , wherein the conduit body defines an average wall thickness between an outer surface of the conduit body and an inner surface of the conduit body, and the average wall thickness is within a range of 0.004 to 0.008 inches.
4 . The embolic material delivery device of claim 1 , wherein the jacket comprises a main portion and a plurality of protrusions connected to the main portion, and each protrusion extends at least partially into a respective cut to fluidically seal the respective cut such that at least the portion of the conduit body is configured to withstand the pressure of 9,000 psi or greater.
5 . The embolic material delivery device of claim 1 , wherein the hypotube comprises a first material defining a first elastic modulus, and the jacket comprises a second material defining a second elastic modulus less than the first elastic modulus to flexibly bridge the plurality of cuts.
6 . The embolic material delivery device of claim 5 , wherein the second material of the jacket comprises a first composition at a first portion of the conduit body and a second composition at a second portion of the conduit body proximal to the first portion, and the second composition is different from the first composition such that the first portion of the conduit body comprises a greater flexibility than the second portion of the conduit body.
7 . The embolic material delivery device of claim 5 , wherein:
the first material of the hypotube comprises stainless steel, nitinol, polyether ether ketone, or a combination thereof; and
the second material of the jacket comprises polyurethane, poly (ether-amide), nylon, or a combination thereof.
8 . The embolic material delivery device of claim 1 , wherein the length of the conduit body is within a range of 140 cm to 200 cm, and the conduit body is configured to withstand the pressure of 9,000 psi or greater along at least a portion of the length.
9 . The embolic material delivery device of claim 1 , wherein an average spacing between neighboring circumferential turns at a first portion of the conduit body is less than an average spacing between neighboring circumferential turns at a second portion of the conduit body proximal to the first portion, such that the first portion of the conduit body comprises a greater flexibility than the second portion of the conduit body.
10 . The embolic material delivery device of claim 1 , wherein the pressure of 9,000 psi or greater is configured to cause the liquid embolic material to flow through the axial lumen at a flow rate of at least 0.05 mL/minute.
11 . The embolic material delivery device of claim 1 , wherein:
the treatment location includes an intracranial aneurysm,
the embolic material delivery device further comprises an expandable structure carried by the conduit body, and
the expandable structure is configured to be disposed at least partially within the intracranial aneurysm to reduce leakage of liquid embolic material from the intracranial aneurysm into a parent vessel of the intracranial aneurysm.
12 . The embolic material delivery device of claim 1 , wherein each cut has a respective cut length along at least one of the plurality of circumferential turns, where cut lengths for the plurality of cuts are equal.
13 . An embolic material delivery device, comprising:
a conduit body configured to extend intravascularly toward a treatment location, wherein the conduit body is elongate, defines an axial lumen, and comprises:
a proximal end portion,
a distal end portion opposite to the proximal end portion along a length of the conduit body, wherein the axial lumen extends between the proximal and distal end portions of the conduit body along a longitudinal axis of the conduit body,
a hypotube comprising an outer surface and an inner surface coaxially disposed around the axial lumen, wherein the hypotube defines a wall thickness between the outer surface and the inner surface, wherein the hypotube defines a plurality of cuts and a plurality of bridges, each bridge interspersed between a respective pair of cuts, wherein the plurality of cuts and the plurality of bridges are disposed along a plurality of circumferential turns extending along the length of the conduit body, wherein the plurality of cuts extend through the wall thickness with each cut extending at least partially circumferentially around the hypotube along a respective cut axis, and wherein an angle between the cut axis and the longitudinal axis is progressively less orthogonal from the distal end portion of the conduit body to the proximal end portion of the conduit body, and
a jacket extending around at least a portion of the outer surface of the hypotube and covering the plurality of cuts,
wherein each bridge has a respective bridge length measured circumferentially around the hypotube along at least one of the plurality of circumferential turns between the respective pair of cuts, the bridge length increasing from the distal end portion of the conduit body to the proximal end portion of the conduit body, and
wherein each cut has a respective cut length along at least one of the plurality of circumferential turns, wherein the cut length is constant from the distal end portion of the conduit body to the proximal end portion of the conduit body.