Scaffold structures and compositions facilitating osseointegration
The present discussion relates to the design fabrication and use of synthetic scaffold structure for bone growth. In certain implementations the scaffold structures are comprised of a plurality of repeating structures each defined by a local topology. The local topologies are defined at a subset of points in their respective volumes by various parameters including, but not limited to, shape index, curvedness, mean curvature, and Gauss curvature.
1 . An implantable bone scaffold structure for facilitating bone growth, comprising:
a scaffold volume comprising a plurality of repeating structures defined by surface area and local topology, wherein at least 2.5% of the surface area comprises local topologies with a shape index between −0.45 and 0.84 and a curvedness between 1.4 and 13.5.
2 . The bone scaffold structure of claim 1 , wherein at least 5.0% of the surface area comprises local topologies with a shape index between −0.45 and 0.84 and a curvedness between 1.4 and 13.5.
3 . The bone scaffold structure of claim 1 , wherein at least 10.0% of the surface area comprises local topologies with a shape index between −0.45 and 0.84 and a curvedness between 1.4 and 13.5.
4 . The bone scaffold structure of claim 1 , wherein at least 20% of the surface area comprises local topologies with a shape index between −0.45 and 0.84 and a curvedness between 1.4 and 13.5.
5 . The bone scaffold structure of claim 1 , wherein the local topologies are characterized by a subset of points in their respective surface having a shape index between 0.25 and 0.65.
6 . The bone scaffold structure of claim 1 , wherein the local topologies are characterized by a subset of points in their respective surface having a curvedness between 2 and 10.
7 . The bone scaffold structure of claim 1 , wherein the scaffold structure comprises a sintered ceramic body.
8 . The bone scaffold structure of claim 1 , wherein the scaffold structure comprises a biologically compatible ceramic material.
9 . The bone scaffold structure of claim 8 , wherein the biologically compatible ceramic material comprises one or more of materials in the calcium phosphate (CaP) class of materials, hydroxyapatite (HA) ceramic, tricalcium phosphate (TCP), calcium sulfates, CaP cements, biphasic CaP, beta TCP, silicon nitride, aluminum oxide, zirconium oxide, bioactive glasses, or carbon-silicon.
10 . The bone scaffold structure of claim 1 , wherein the scaffold structure comprises a biologically compatible polymeric material.
11 . The bone scaffold structure of claim 10 , wherein the biologically compatible polymeric material comprises one or more of polycaprolactone (PCL), polyether ether ketone (PEEK), poly(methyl methacrylate) (PMMA), polylactic acid (PLA), polytetrafluoroethylene, or polyurethane.
12 . The bone scaffold structure of claim 1 , wherein the scaffold structure comprises a biologically compatible metal or metal alloy.
13 . The bone scaffold structure of claim 12 , wherein the biologically compatible metal or metal alloy comprises one or more of titanium or titanium alloys, cobalt chrome, or stainless steel.
14 . The bone scaffold structure of claim 1 , wherein the plurality of repeating structures comprise repeating units having unit cell sizes between 100 μm to 2,000 μm.
15 . The bone scaffold structure of claim 1 , wherein the plurality of repeating structures comprise repeating units having unit cell sizes between 300 μm to 1,000 μm.