IP Library › Granted Patent US 12667552
Granted Patent B2
US 12667552 · App. 17/413,991 · Granted Jun 30, 2026

Dietary butyrate

Inventors: Elizabeth Forbes-Blom (Epalinges, CH); Martinas Kuslys (Grosshoechstetten, CH); Ralf Heine (Berlin, DE); Amaury Patin (Lausanne, CH)
Assignee: Societe des Produits Nestle S.A.
A61K31/23A23L33/12A23L33/21A23L33/40A23P10/40A61K31/231A61K45/06A23V2002/00
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Quick Facts
Patent No.
US 12667552
App. No.
17/413,991
Granted
Jun 30, 2026
Kind
B2
Abstract

A compound having the formula (1), (2), (3) or (4), or combinations thereof, for use in the prevention or treatment of dehydration, and/or in the treatment of diarrhea, wherein R1, R2, R3, R4, R5 and R6 are independently, a long chain fatty acid having between 16 and 20 carbons.

Claims (10)

1 . A method for the prevention or treatment of dehydration due to diarrhea in a subject in need thereof, the method comprising orally administering to the subject a compound having a formula selected from the group consisting of:

or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently, a long chain fatty acid having from 16 to 20 carbons to the subject.

2 . The method according to claim 1 , wherein the method comprises administering the compound in combination with an oral rehydration solution (ORS).

3 . The method according to claim 1 , wherein the compound is present in a form selected from the group consisting of an oral rehydration solution (ORS), a nutritional composition, a dietary supplement, an infant formula and a follow on-formula.

4 . The method according to claim 1 , wherein a combination of the compound having formula (1) and the compound having formula (2) is administered.

5 . The method according to claim 1 , wherein a combination of the compound having formula (1) and the compound having formula (2) is administered, and wherein the combination is present in a composition that comprises the compound having formula (1) in an amount of at least 10% by weight of total butyrate moiety containing triglycerides in the composition, and the compound having formula (2) in an amount of at least 10% by weight of the total butyrate moiety containing triglycerides in the composition.

6 . The method according to claim 1 , wherein the compound having the formula (4) is present in a composition that comprises the compound having formula (4) as a main butyrate moiety containing triglyceride in the composition, wherein the compound of formula (4) provides at least 20%, by weight of total butyrate moiety containing triglycerides in the composition.

7 . The method according to claim 1 , wherein a combination of the compound having formula (1), the compound having formula (2), the compound having formula (3) and the compound having formula (4) is administered.

8 . The method according to claim 1 , wherein R 1 , R 2 , R 3 , R 4 , R 5 and/or R 6 is selected from the group consisting of oleic acid, palmitic acid, and linoleic acid.

9 . The method according to claim 1 , wherein each of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is oleic acid.