Application of medium-chain fatty acid mixed structural lipid in improving diet-induced disorders of glucose and lipid metabolism
The present disclosure provides an application of a medium-chain fatty acid mixed structural lipid in improving diet-induced disorders of glucose (Glu) and lipid metabolism. The medium-chain fatty acid mixed structural lipid includes capric lauric triglyceride and capric lauric diglyceride, and a mass percentage content ratio of capric acid to lauric acid in the medium-chain fatty acid mixed structure lipid is 1:1-1:4. In the present disclosure, it is found that adding medium-chain fatty acid mixed glyceride rich in lauric acid into high-energy feed can improve diet-induced disorders of Glu and lipid metabolism, including but not limited to reducing a serum Glu level, improving Glu homeostasis, reducing a serum low density lipoprotein cholesterol (LDL-C) level and improving expressions of genes related to Glu and lipid metabolism.
1 . A medium-chain fatty acid mixed structural lipid, comprising capric lauric triglyceride and capric lauric diglyceride, wherein a mass percentage content ratio of capric acid to lauric acid in the medium-chain fatty acid mixed structure lipid is 1:1-1:4;
the capric lauric triglyceride is monocapric dilauric triglyceride and dicaapric monolauric triglyceride; and the capric lauric diglyceride is monocapric monolauric diglyceride;
in percentage by mass, the medium-chain fatty acid mixed structural lipid comprises:
monocapric dilauric triglyceride not less than 30%;
15-30% of dicaapric monolauric triglyceride; and
20-25% of monocapric monolauric diglyceride; and
wherein preparation of the medium-chain fatty acid mixed structural lipid comprises:
mixing the capric acid, the lauric acid and glycerol at 45-75° C., fully liquefying and evenly mixing a mixture, adding immobilized lipase or a chemical catalyst, pumping vacuum or adding molecular sieves, maintaining heat reaction for 4-12 h, filtering and removing solids, and removing unreacted fatty acid, glycerol and monoglyceride by molecular distillation or a chemical method to obtain the medium-chain fatty acid mixed structural lipid.
2 . The medium-chain fatty acid mixed structure lipid according to claim 1 , wherein,
the monocapric dilauric triglyceride is at least one of 1-capric-2,3-dilaurin glycerol ester and 1,3-dilaurin-2-capric glycerol ester;
the dicaapric monolauric triglyceride is at least one of 1,2-dicaapric-3-laurin glycerol ester and 1,3-dicaapric-2-laurin glycerol ester; and
the monocapric monolauric diglyceride is at least one of 1-capric-3-laurin diglyceride, 1-capric-2-laurin diglyceride and 2-capric-1-laurin diglyceride.
3 . A food additive for treating Glu homeostasis, regulating cholesterol metabolism, reducing lipid synthesis in liver, and improving disorders of Glu and lipid metabolism induced by high-fat diet wherein the food additive comprises the medium-chain fatty acid mixed structural lipid according to claim 1 .
4 . A food additive for treating Glu homeostasis, regulating cholesterol metabolism, reducing lipid synthesis in liver, and improving disorders of Glu and lipid metabolism induced by high-fat diet wherein the food additive comprises the medium-chain fatty acid mixed structural lipid according to claim 2 .
5 . A high-energy feed for administration to a subject wherein the high-energy feed comprises the food additive according to claim 3 .
6 . A high-energy feed for administration to a subject wherein the high-energy feed comprises the food additive according to claim 4 .
7 . A method of using a medium-chain fatty acid mixed structural lipid comprising:
providing a medium-chain fatty acid mixed structural lipid according to claim 1 ; and
adding the medium-chain fatty acid mixed structural lipid to a health care product or food.
8 . A method of using a medium-chain fatty acid mixed structural lipid comprising:
providing a medium-chain fatty acid mixed structural lipid according to claim 2 ; and
adding the medium-chain fatty acid mixed structural lipid to a health care product or food.
9 . The method according to claim 7 wherein the health care product comprises a soft capsule.
10 . The method according to claim 8 , wherein the health care product comprises a soft capsule.
11 . The high-energy feed according to claim 5 , wherein the high energy feed has a fat-to-energy ratio in a range of 35-70%.
12 . The high-energy feed according to claim 5 , wherein the high energy feed has a fat-to-energy ratio of 45%.
13 . The high-energy feed according to claim 6 , wherein the high energy feed has a fat-to-energy ratio in a range of 35-70%.
14 . The high-energy feed according to claim 6 , wherein the high energy feed has a fat-to-energy ratio of 45%.