IP Library Granted Patent US 12667553
Granted Patent B2
US 12667553 · App. 19/215,283 · Granted Jun 30, 2026

Application of medium-chain fatty acid mixed structural lipid in improving diet-induced disorders of glucose and lipid metabolism

Inventors: Fengqin Feng (Hangzhou, CN); Minjie Zhao (Hangzhou, CN); Xiyu Fu (Hangzhou, CN); Jing Wang (Hangzhou, CN); Liangyong Guo (Hangzhou, CN)
Assignee: Hangzhou Kangyuan Food Technology Co., LTD
A61K31/23A61P3/06A61P3/08
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Quick Facts
Patent No.
US 12667553
App. No.
19/215,283
Granted
Jun 30, 2026
Kind
B2
Abstract

The present disclosure provides an application of a medium-chain fatty acid mixed structural lipid in improving diet-induced disorders of glucose (Glu) and lipid metabolism. The medium-chain fatty acid mixed structural lipid includes capric lauric triglyceride and capric lauric diglyceride, and a mass percentage content ratio of capric acid to lauric acid in the medium-chain fatty acid mixed structure lipid is 1:1-1:4. In the present disclosure, it is found that adding medium-chain fatty acid mixed glyceride rich in lauric acid into high-energy feed can improve diet-induced disorders of Glu and lipid metabolism, including but not limited to reducing a serum Glu level, improving Glu homeostasis, reducing a serum low density lipoprotein cholesterol (LDL-C) level and improving expressions of genes related to Glu and lipid metabolism.

Claims (28)

1 . A medium-chain fatty acid mixed structural lipid, comprising capric lauric triglyceride and capric lauric diglyceride, wherein a mass percentage content ratio of capric acid to lauric acid in the medium-chain fatty acid mixed structure lipid is 1:1-1:4;

the capric lauric triglyceride is monocapric dilauric triglyceride and dicaapric monolauric triglyceride; and the capric lauric diglyceride is monocapric monolauric diglyceride;

in percentage by mass, the medium-chain fatty acid mixed structural lipid comprises:

monocapric dilauric triglyceride not less than 30%;

15-30% of dicaapric monolauric triglyceride; and

20-25% of monocapric monolauric diglyceride; and

wherein preparation of the medium-chain fatty acid mixed structural lipid comprises:

mixing the capric acid, the lauric acid and glycerol at 45-75° C., fully liquefying and evenly mixing a mixture, adding immobilized lipase or a chemical catalyst, pumping vacuum or adding molecular sieves, maintaining heat reaction for 4-12 h, filtering and removing solids, and removing unreacted fatty acid, glycerol and monoglyceride by molecular distillation or a chemical method to obtain the medium-chain fatty acid mixed structural lipid.

2 . The medium-chain fatty acid mixed structure lipid according to claim 1 , wherein,

the monocapric dilauric triglyceride is at least one of 1-capric-2,3-dilaurin glycerol ester and 1,3-dilaurin-2-capric glycerol ester;

the dicaapric monolauric triglyceride is at least one of 1,2-dicaapric-3-laurin glycerol ester and 1,3-dicaapric-2-laurin glycerol ester; and

the monocapric monolauric diglyceride is at least one of 1-capric-3-laurin diglyceride, 1-capric-2-laurin diglyceride and 2-capric-1-laurin diglyceride.

3 . A food additive for treating Glu homeostasis, regulating cholesterol metabolism, reducing lipid synthesis in liver, and improving disorders of Glu and lipid metabolism induced by high-fat diet wherein the food additive comprises the medium-chain fatty acid mixed structural lipid according to claim 1 .

4 . A food additive for treating Glu homeostasis, regulating cholesterol metabolism, reducing lipid synthesis in liver, and improving disorders of Glu and lipid metabolism induced by high-fat diet wherein the food additive comprises the medium-chain fatty acid mixed structural lipid according to claim 2 .

5 . A high-energy feed for administration to a subject wherein the high-energy feed comprises the food additive according to claim 3 .

6 . A high-energy feed for administration to a subject wherein the high-energy feed comprises the food additive according to claim 4 .

7 . A method of using a medium-chain fatty acid mixed structural lipid comprising:

providing a medium-chain fatty acid mixed structural lipid according to claim 1 ; and

adding the medium-chain fatty acid mixed structural lipid to a health care product or food.

8 . A method of using a medium-chain fatty acid mixed structural lipid comprising:

providing a medium-chain fatty acid mixed structural lipid according to claim 2 ; and

adding the medium-chain fatty acid mixed structural lipid to a health care product or food.

9 . The method according to claim 7 wherein the health care product comprises a soft capsule.

10 . The method according to claim 8 , wherein the health care product comprises a soft capsule.

11 . The high-energy feed according to claim 5 , wherein the high energy feed has a fat-to-energy ratio in a range of 35-70%.

12 . The high-energy feed according to claim 5 , wherein the high energy feed has a fat-to-energy ratio of 45%.

13 . The high-energy feed according to claim 6 , wherein the high energy feed has a fat-to-energy ratio in a range of 35-70%.

14 . The high-energy feed according to claim 6 , wherein the high energy feed has a fat-to-energy ratio of 45%.