Gel containing pirfenidone
The invention relates to a gel composition containing pirfenidone, which is advantageous over other cutaneously administered pharmaceutical forms known in the prior art and which can be used in treatment for the restoration of tissues with fibrotic lesions and for the prevention of fibrotic lesions.
1 . A composition of pirfenidone gel consisting of:
(i) 2-12% pirfenidone;
(ii) 0.4-1.2% of Carbomer 940®;
(iii) 10-30% of N-methylpyrrolidone;
(iv) 5-15% of macrogolglycerol hydroxystearate 40;
(v) 0.2-1% of diazolidinyl urea and iodopropynyl butylcarbamate;
(vi) 0.4-1.2% of triethanolamine; and
(vii) water.
2 . The composition of claim 1 , wherein the composition consists of 8% pirfenidone, 0.5% of Carbomer 940®, 20% of N-methylpyrrolidone, 11.5% of macrogolglycerol hydroxystearate 40, 0.5% of diazolidinyl urea and iodopropynyl butylcarbamate, 0.5% of triethanolamine, and 59% of water.
3 . The composition of claim 1 , wherein the composition is an anti-fibrotic composition.
4 . The composition of claim 1 , wherein the composition is an anti-inflammatory composition.
5 . The composition of claim 1 , wherein the composition consists of:
(i) 8% pirfenidone;
(ii) 0.5% of Carbomer 940®;
(iii) 10-30% of N-methylpyrrolidone;
(iv) 5-15% of macrogolglycerol hydroxystearate 40;
(v) 0.5% of diazolidinyl urea and iodopropynyl butylcarbamate;
(vi) 0.5% of triethanolamine; and
(vii) water.
6 . The composition of claim 5 , wherein the composition is an anti-fibrotic composition.
7 . The composition of claim 5 , wherein the composition is an anti-inflammatory composition.