Therapeutic methods and compositions for treating movement disorders
The invention provides therapeutic methods, pharmaceutical compositions, and unit dose formulations for treating movement disorders, such as using a muscarinic acetylcholine receptor inhibitor in combination with a muscarinic acetylcholine receptor activator to treat dystonia. In some aspects, the invention provides a method of treating a movement disorder in a patient, where the method comprises administering to a patient in need thereof (i) a muscarinic acetylcholine receptor inhibitor in an amount effective to treat the movement disorder and (ii) a muscarinic acetylcholine receptor activator in an amount effective to reduce the frequency and/or magnitude of at least one side effect of the muscarinic acetylcholine receptor inhibitor, to thereby treat the movement disorder.
1 . An oral pharmaceutical composition, comprising:
(i) a muscarinic acetylcholine receptor inhibitor in an amount effective to treat a movement disorder,
(ii) a muscarinic acetylcholine receptor activator in an amount effective to reduce the frequency of at least one side effect of the muscarinic acetylcholine receptor inhibitor, and
(iii) a pharmaceutically acceptable carrier,
wherein the muscarinic acetylcholine receptor inhibitor is (R)-trihexyphenidyl or a pharmaceutically acceptable salt thereof,
wherein the muscarinic acetylcholine receptor activator is bethanechol or a pharmaceutically acceptable salt thereof, and
wherein the pharmaceutical composition comprises the (R)-trihexyphenidyl and the bethanechol in a weight ratio of (R)-trihexyphenidyl to bethanechol of about 1:1.1 to about 1:20.
2 . The oral pharmaceutical composition of claim 1 , wherein the (R)-trihexyphenidyl or pharmaceutically acceptable salt thereof has a stereochemical purity of at least 95% enantiomeric excess.
3 . The oral pharmaceutical composition of claim 1 , wherein the oral pharmaceutical composition is a controlled release formulation.
4 . The oral pharmaceutical composition of claim 1 , wherein the oral pharmaceutical composition is dosed once per day.
5 . The oral pharmaceutical composition of claim 1 , wherein the oral pharmaceutical composition is dosed twice per day.
6 . The oral pharmaceutical composition of claim 1 , wherein the movement disorder is selected from the group consisting of dystonia, primary dystonia, secondary dystonia, multifocal dystonia, tardive dystonia, drug-induced dystonia, cerebral palsy-associated dystonia, focal dystonia, cervical dystonia, blepharospasm, hand dystonia, writer's cramp, musician's dystonia, leg dystonia, foot dystonia, segmental dystonia, generalized dystonia, genetic dystonia, Multiple System Atrophy, Progressive Supranuclear Palsy, tremor, Parkinson's disease, drug-induced Parkinsonism, Huntington's disease, and dementia with Lewy Bodies.
7 . The oral pharmaceutical composition of claim 1 , wherein the side effect is selected from the group consisting of dry mouth, dry eye, blurry vision, tachycardia, constipation, urine retention, impaired vision, nausea, cramping, reduced urinary voiding, flushed skin, fever, reduced sweating, cardiac arrhythmia, and combinations thereof.
8 . The oral pharmaceutical composition of claim 1 , wherein the movement disorder is dystonia.
9 . The oral pharmaceutical composition of claim 1 , wherein the side effect is constipation.
10 . The oral pharmaceutical composition of claim 1 , wherein the side effect is dizziness.
11 . An oral pharmaceutical composition, comprising:
(i) a muscarinic acetylcholine receptor inhibitor in an amount effective to treat a movement disorder
(ii) a muscarinic acetylcholine receptor activator in an amount effective to reduce the frequency of at least one side effect of the muscarinic acetylcholine receptor inhibitor, and
(iii) a pharmaceutically acceptable carrier,
wherein the composition is sufficient to provide an in vivo plasma profile of the muscarinic acetylcholine receptor inhibitor when administered to a subject in need thereof,
wherein the rate of rise of the plasma concentration of the muscarinic acetylcholine receptor inhibitor is less than about 15 ng/mL/hr,
wherein the muscarinic acetylcholine receptor inhibitor is (R)-trihexyphenidyl or a pharmaceutically acceptable salt thereof, wherein the muscarinic acetylcholine receptor activator is bethanechol or a pharmaceutically acceptable salt thereof, and
wherein the oral pharmaceutical composition is a controlled release formulation.
12 . The oral pharmaceutical composition of claim 11 , wherein the magnitude or severity of at least one side effect of the (R)-trihexyphenidyl or a pharmaceutically acceptable salt thereof is reduced in a subject administered the oral pharmaceutical composition compared to a subject administered an immediate release formulation of trihexyphenidyl or a pharmaceutically acceptable salt thereof alone.
13 . The oral pharmaceutical composition of claim 12 , wherein the side effect is selected from the group consisting of dizziness, lightheadedness, headache, drowsiness, confusion, reduced concentration, euphoria, elevated mood, hallucinations, agitation, irritability, sensory disturbances, blurry vision, and impaired vision.
14 . The oral pharmaceutical composition of claim 11 , wherein the movement disorder is selected from the group consisting of dystonia, primary dystonia, secondary dystonia, multifocal dystonia, tardive dystonia, drug-induced dystonia, cerebral palsy-associated dystonia, focal dystonia, cervical dystonia, blepharospasm, hand dystonia, writer's cramp, musician's dystonia, leg dystonia, foot dystonia, segmental dystonia, generalized dystonia, genetic dystonia, Multiple System Atrophy, Progressive Supranuclear Palsy, tremor, Parkinson's disease, drug-induced Parkinsonism, Huntington's disease, and dementia with Lewy Bodies.
15 . The oral pharmaceutical composition of claim 11 , wherein the side effect is selected from the group consisting of dry mouth, dry eye, blurry vision, tachycardia, constipation, urine retention, impaired vision, nausea, cramping, reduced urinary voiding, flushed skin, fever, reduced sweating, cardiac arrhythmia, and combinations thereof.
16 . The oral pharmaceutical composition of claim 11 , wherein the movement disorder is dystonia.
17 . The oral pharmaceutical composition of claim 11 , wherein the side effect is constipation.
18 . The oral pharmaceutical composition of claim 11 , wherein the side effect is dizziness.