Paraxanthine-based bioactive composition and method of use thereof
The disclosed compositions and methods relate to compositions for human consumption comprising paraxanthine and a cholinergic agent and/or theanine. The disclosed compositions are useful for promoting cognitive function, energy, athletic performance and providing neuroprotective anti-oxidative effects.
1 . A method for improving physical performance in a subject, comprising: providing the subject with a composition comprising about 50 mg to about 800 mg of paraxanthine and an effective amount of alpha-GPC (L-alpha glycerylphosphorylcholine).
2 . The method of claim 1 , wherein paraxanthine is present in the composition in an amount from about 50 mg to about 400 mg.
3 . The method of claim 2 , wherein the alpha-GPC is present in the composition in an amount from about 50 mg to about 400 mg.
4 . The method of claim 2 , wherein the composition is substantially free of caffeine.
5 . The method of claim 2 , wherein administration of the composition to a subject produces a synergistic increase in physical performance relative to the administration of a comparable dose of paraxanthine or alpha-GPC.
6 . The method of claim 1 further comprising a paraxanthine congener or paraxanthine analog selected from the group consisting of caffeine, methyl caffeine, theobromine, theophylline, liberine, methylliberine, theacrine and combinations thereof.
7 . The method of claim 6 , wherein the paraxanthine congener or paraxanthine analog is caffeine.
8 . A method of improving cognitive function in a subject comprising administering to the subject a composition comprising about 50 mg to about 800 mg of paraxanthine and an effective amount of alpha-GPC.
9 . The method of claim 8 , wherein administration of the composition increases one or more of attention, information acquisition, information processing, working memory, short-term memory, long-term memory, anterograde memory, retrograde memory, memory retrieval, discrimination learning, decision-making, inhibitory response control, attentional set-shifting, delayed reinforcement learning, reversal learning, the temporal integration of voluntary behavior, speed of processing, reasoning, problem solving and/or social cognition.
10 . The method of claim 9 , wherein administration of the composition enhances dopaminergic tone, cholinergic tone, and/or brain BDNF levels.
11 . The method of claim 8 , wherein administration of the composition is neuroprotective against oxidative stress.
12 . The method of claim 8 further comprising a paraxanthine congener or paraxanthine analog selected from the group consisting of caffeine, methyl caffeine, theobromine, theophylline, liberine, methylliberine, theacrine and combinations thereof.
13 . The method of claim 8 , wherein the alpha-GPC is present in the composition in an amount from about 50 mg to about 400 mg.
14 . The method of claim 8 , wherein the composition is substantially free of caffeine.
15 . The method of claim 8 , wherein administration of the composition to a subject produces a synergistic increase in cognitive function relative to the administration of a comparable dose of paraxanthine or alpha-GPC.
16 . A method for enhancing energy in a subject comprising administering to the subject a composition comprising about 50 mg to about 800 mg of paraxanthine and an effective amount of alpha-GPC.