IP Library Granted Patent US 12667594
Granted Patent B2
US 12667594 · App. 17/241,412 · Granted Jun 30, 2026

Hyaluronic composition

Inventors: Timothy Ganey (Tampa, FL); Harry Thomas Temple (Miami, FL); Shabnam Namin (Miami, FL)
Assignee: Vivex Biologics Group, Inc.
A61K35/58A61K8/735A61K8/987A61K31/728A61K35/32A61K35/35A61K38/1841A61K38/39A61K47/02A61L27/10A61L27/12A61L27/26A61L27/3608A61L27/3612A61L27/56A61Q17/005A61L2400/06A61L2400/12A61L2430/06A61L2430/24
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Quick Facts
Patent No.
US 12667594
App. No.
17/241,412
Granted
Jun 30, 2026
Kind
B2
Abstract

A composition has hyaluronic acid and one or more materials as an admixture. The hyaluronic acid is derived from a fascia tissue layer of an alligator, the fascia layer located below a hide and above muscle tissue. The one or more materials as the admixture to the hyaluronic acid can be a carrier, diluent or excipient. The hyaluronic acid is extracted from the fascia tissue layer in the form of an oil having an oily viscosity with a molecular weight of 30,000 or greater. The oil extracted includes the hyaluronic acid and includes sodium or salts of hyaluronic acid. The oil extracted is anti-inflammatory to human tissue.

Claims (12)

1 . A composition comprising:

hyaluronic acid obtained from a fascia tissue layer of an alligator, wherein the fascia layer is located below a hide and above muscle tissue, wherein the hyaluronic acid is extracted from the fascia tissue layer in the form of an oil having an oily viscosity with a molecular weight of 30,000 Da or greater, and wherein the extracted oil comprises hyaluronic acid and sodium or salts of hyaluronic acid;

one or more polymer materials as an admixture to the hyaluronic acid and sodium or salts of hyaluronic acid in the oil as a carrier, diluent, or excipient, wherein the hyaluronic acid is infused in the carrier, diluent, or excipient; wherein the carrier is of high porosity exhibiting 50 or greater void volume with a variable pore size of 50 to 1000 microns; wherein the high porosity carrier has a plurality of open cells or pores; wherein some of the open cells or pores are interconnected forming passages through the carrier; wherein some of the open cells or pores are separated by windows, the windows being of a 10 micron thickness or greater; wherein the carrier is an osteoconductive/osteoinductive material for inducing bone growth and repair;

wherein the composition is a hyaluronic acid foam that further comprises micro and nano sized ceramic particles selected from a group consisting of hydroxyapatite, calcium phosphates, silicates, B-TCP tetracalcium phosphate, and calcium carbonate, and combinations thereof; and cartilage particles or cartilage fluff imbued in the foam configured for use in cartilage tissue repair.

2 . The composition of claim 1 , wherein the composition of the hyaluronic acid foam further comprises demineralized bone in the form of fibers and/or particles imbued in the hyaluronic acid foam.

3 . The composition of claim 1 , wherein the composition further comprises acellular biologic materials including exosomes, vesicles, cell fragments, ligands, lipid rafts, organelles, or a combination thereof.

4 . The composition of claim 1 , further comprising TGF-b added to the hyaluronic acid foam.

5 . A composition comprising:

hyaluronic acid obtained from a fascia tissue layer of an alligator, wherein the fascia layer is located below a hide and above muscle tissue, wherein the hyaluronic acid is extracted from the fascia tissue layer in the form of an oil having an oily viscosity with a molecular weight of 30,000 or greater, and wherein the extracted oil comprises the hyaluronic acid and sodium or salts of hyaluronic acid; and

one or more polymer materials as an admixture to the hyaluronic acid and sodium or salts of hyaluronic acid in the oil as a carrier, diluent, or excipient, wherein the one or more polymer materials comprises collagen and amniotic fluid,

wherein the composition is reconstituted as a paste or gel configured for use in for topical cosmetics, skin treatments or wound care or hand sanitization.

6 . The composition of claim 5 , further comprising a non-alcohol based germicidal agent.