Composition for preventing, improving or treating benign prostatic hyperplasia or alopecia, comprising heat-killed probiotics as active ingredient
Provided is a pharmaceutical composition for preventing or treating benign prostatic hyperplasia or alopecia, comprising lactic acid bacteria of Enterococcus genus as an active ingredient. The pharmaceutical composition of the present invention can replace the conventional therapeutic agents against treating benign prostatic hyperplasia or alopecia, such as finasteride or dutasteride. In particular, by introducing heat-killed probiotics of Enterococcus faecalis , the effect of preventing or treating benign prostatic hyperplasia or alopecia can be further enhanced.
1 . A method of treating benign prostatic hyperplasia (BPH) in a subject, the method comprising orally administering to the subject a composition comprising heat-killed probiotics of Enterococcus faecalis EF-2001 as an active ingredient.
2 . The method of claim 1 , wherein the administering reduces expression of an androgen receptor (AR) signaling factor selected from estrogen receptors (ER), androgen receptor (AR), and prostate specific antigen (PSA).
3 . The method of claim 1 , wherein the administering increases expression of Bax and/or decreases expression of Bcl-2 in prostate tissue.
4 . The method of claim 1 , wherein the administering reduces expression of a proliferation marker selected from proliferating cell nuclear antigen (PCNA) and Cyclin D1.