IP Library › Granted Patent US 12667597
Granted Patent B2
US 12667597 · App. 18/279,040 · Granted Jun 30, 2026

Probiotic compositions useful in the prevention and/or treatment of gastrointestinal disorders

Inventors: Rosella Malanchin (Origgio, IT); Cristiana Piangiolino (Origgio, IT); Silvia Castegnaro (Origgio, IT); Federica Carlomagno (Origgio, IT); Chiara Pesciaroli (Origgio, IT)
Assignee: SYNBALANCE SRL
A61K35/747A61K35/745A61P1/00
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Quick Facts
Patent No.
US 12667597
App. No.
18/279,040
Granted
Jun 30, 2026
Kind
B2
Abstract

In particular, this invention refers to a composition comprising a probiotic combination comprising: a) at least one strain of the genus Lactobacillus selected from the species Lactobacillus plantarum ; and c) at least one strain belonging to the genus Bifidobacterium selected from the species Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium infantis ; wherein said composition is for use in a method for the prevention and/or treatment of chronic inflammatory bowel disease (Inflammatory Bowel Disease IBD).

Claims (80)

1 . A composition comprising a probiotic combination consisting of:

a) at least one strain of the genus Lactobacillus selected from the species Lactobacillus plantarum ; and

c) at least one strain belonging to the genus Bifidobacterium selected from the species Bifidobacterium lactis, Bifidobacterium longum , and Bifidobacterium infantis;

wherein said probiotic combination consists of:

a strain of Lactobacillus plantarum PBS067 in combination with a strain of Bifidobacterium lactis BL050, Bifidobacterium longum BLG240 and Bifidobacterium infantis BI221.

2 . The composition according to claim 1 , wherein said probiotic combination consists of a strain of Lactobacillus plantarum PBS067 in combination with a strain of Bifidobacterium lactis BL050, Bifidobacterium longum BLG240 and Bifidobacterium infantis BI221, wherein said strains are present in a weight ratio of 1:1.7:5:5 or 1:1:1:1 ratio expressed in CFU.

3 . The composition according to claim 1 , wherein said composition is formulated for oral administration.

4 . The composition according to claim 1 , wherein said composition is as follows:

INGREDIENTS

% wt/wt

BILLION/DOSE

L. plantarum PBS067

1.25

1

B. lactis BL050

1.25

1

B. infantis BI221

1.375

1

B. longum BLG240

2

1

FOS

68

—

Aroma

1.25

—

Vitamin B6

0.022

—

Sucralose

0.08

—

Silicon dioxide

1

—

Maltodextrin

23.773

—

5 . A method for treating a chronic inflammatory bowel disease, comprising administering to a subject in need thereof a composition of claim 1 .

6 . The method of claim 5 , wherein the subject has Crohn's disease or ulcerative colitis.

7 . The method of claim 5 , comprising administering to a subject in need thereof a composition wherein the probiotic combination consists of a strain of Lactobacillus plantarum PBS067 in combination with a strain of Bifidobacterium lactis BL050, Bifidobacterium longum BLG240 and Bifidobacterium infantis BI221.

8 . The method of claim 7 , wherein said strains are present in the composition in a weight ratio of 1:1.7:5:5 or 1:1:1:1 ratio expressed in CFU.

9 . The method of claim 5 , wherein in the composition is administered orally.

10 . The method of claim 5 , wherein in the composition comprises:

INGREDIENTS

% wt/wt

BILLION/DOSE

L. plantarum PBS067

1.25

1

B. lactis BL050

1.25

1

B. infantis BI221

1.375

1

B. longum BLG240

2

1

FOS

68

—

Aroma

1.25

—

Vitamin B6

0.022

—

Sucralose

0.08

—

Silicon dioxide

1

—

Maltodextrin

23.773

—