Composition for preventing, treating or alleviating diabetes, comprising LGI3-derived peptide as an active ingredient
View Patent ↗The present invention relates to a composition and the like, for preventing, treating or alleviating diabetes, comprising an LGI3-derived peptide as an effective component. The composition comprising, as an active ingredient, an LGI3-derived peptide comprising an amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 2 of the present invention exhibits an inhibitory effect on weight gain, elevation of blood glucose levels, pancreas and liver damage, elevation of blood lipid levels, and an increase of insulin resistance indexes accompanied by diabetes and diabetes-associated metabolic disorders associated with diabetes, and thus can prevent, treat, or alleviate diabetes and metabolic disorders associated with diabetes.
1 . A method of treating pancreatic exocrine insufficiency generated in diabetes in a subject comprising:
administering a pharmaceutically effective amount of a composition comprising a leucine-rich repeat LGI family member 3 (LGI3)-derived peptide comprising an amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 2 as an active ingredient into the subject, and
wherein the LGI3-derived peptide increases zymogen granules of the pancreas and pancreatic weight, and reduces a blood sugar level.
2 . A method of treating a diabetes-associated metabolic disorder in a subject by administering a pharmaceutical composition comprising an effective amount a leucine-rich repeat LGI family member 3 (LGI3)-derived peptide comprising an amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 2 as an active ingredient into the subject wherein the diabetes-associated metabolic disorder is one or more selected from the group consisting of hyperglycemia, liver damage associated with an elevated aspartate aminotransferase (AST) level, and pancreatic damage.