Gas treatment delivery systems and methods
The present disclosure provides apparatuses and systems for delivering a measureable absorbed-dose of a gaseous activating agent to a fluid including a biological liquid and/or cells. The apparatuses or systems include a gas-fluid contact device configured to controllably rotate or oscillate a control member having an interior surface in contact with the fluid and a control system configured to control rotation or oscillation of the contact member by the gas-fluid contact device. In some embodiments, the control system is further configured to control absorption of the gaseous activating agent by the fluid. The present disclosure also provides methods of treating a fluid including a biological liquid or cells with a gaseous activating agent to controllably activate the fluid.
1 . An apparatus for treating a fluid comprising a biological liquid and/or cells or particles derived from a biological liquid with an activating agent, the apparatus comprising:
a gas-fluid contact device configured to controllably rotate a contact member, the contact member configured to receive the fluid and having an interior surface configured to be in contact with the received fluid;
a gas inlet line configured to receive a gas comprising the activating agent from a gas source for delivery to the contact member;
one or more first sensors for analyzing a composition of the gas from the gas source to be delivered to the gas-fluid contact device;
a gas outlet line for outputting gas from the contact member;
one or more second sensors for analyzing a composition of the gas output from the gas-fluid contact device; and
a control system configured to:
control rotation of the contact member by the gas-fluid contact device, and control one or both of a flow rate of the gas into the contact member and a composition of the gas flowing into the contact member;
continuously or periodically determine a current total amount of activating agent absorbed by or reacted with the fluid based on measurements from the one or more first sensors and the one or more second sensors;
determine a current rate of activating agent absorption by or reaction with the fluid; and
cease flow of the gas comprising the activating agent to the contact member and/or initiate flow of a purge gas into the contact member before the current total amount of activating agent absorbed by or reacted with the fluid equals a total pre-specified desired amount based, at least in part, on the current total amount of activating agent absorbed by or reacted with the fluid and the current rate of activating agent absorption by or reaction with the fluid such that after all the activating agent has been purged, the total pre-specified desired amount of activating agent absorbed by or reacted with the fluid has been achieved without exceeding a pre-specified limit.
2 . The apparatus of claim 1 , wherein the control system is configured to determine the current rate of activating agent absorption by or reaction with the fluid based on the composition of the gas delivered to the gas-fluid contact device and flowing into the contact member, the composition of the gas flowing out of the contact member and output from gas-fluid contact device, and the flow rate of gas through the gas-fluid contact device and into the contact member.
3 . The apparatus of claim 1 , wherein the control system is configured to alter one or both of the composition of the gas delivered to the gas-fluid contact device and into the contact member and the flow rate of the gas delivered to the gas-fluid contact device and into the contact member based, at least in part, on the determined current rate of activating agent absorption by or reaction with the fluid.
4 . The apparatus of claim 1 , wherein the control system is further configured to continuously or periodically determine a current estimate of a total activating agent contact time required to achieve the total pre-specified desired amount of the activating agent absorbed by or reacted with the fluid based, at least in part, on the determined current rate of activating agent absorption of or reaction by the fluid.
5 . The apparatus of claim 1 , wherein the gas-fluid contact device further comprises a first fluid tube configured to be connected with a first fluid line for delivering the fluid to be treated into the contact member.
6 . The apparatus of claim 5 , wherein the first fluid tube is also configured for removal of the treated fluid from the contact member.
7 . The apparatus of claim 1 , wherein the gas-fluid contact device further comprises a second fluid tube configured to be connected with a second fluid line for removal of the treated fluid from the contact member.
8 . The apparatus of claim 1 , wherein the apparatus is configured to enable at least a portion of the gas-fluid contact device that engages the contact member to be rotatably or pivotably tilted to facilitate removal of the fluid from the contact member via gravity.
9 . The apparatus of claim 1 , further comprising a pivotable joint enabling a portion of the gas-fluid contact device that engages the contact member to be tilted relative to another portion of the apparatus to facilitate removal of the treated fluid from the contact member via gravity.
10 . The apparatus of claim 1 , wherein the apparatus further comprises a rotating joint configured to:
sealably and rotatably couple the contact member to the gas-fluid contact device;
connect the gas inlet line with the contact member;
connect the gas outlet line with the contact member; and
remain connected to the gas inlet line and the gas outlet line during rotation of the contact member.
11 . The apparatus of claim 10 , wherein the rotating joint is further configured to receive the fluid to be treated from a first fluid line and to remain connected to the first fluid line during rotation of the contact member.
12 . The apparatus of claim 11 , wherein the rotating joint comprises:
a gas inlet tube configured to connect with the gas inlet line;
a gas outlet tube configured to connect with the gas outlet line; and
a first fluid tube configured to connect with the first fluid line.
13 . The apparatus of claim 12 , wherein the rotating joint further comprises a second fluid tube configured to connect with a second fluid line for draining the treated fluid from the contact member.
14 . The apparatus of claim 12 , wherein the first fluid tube is a first fluid inlet and outlet tube and the first fluid line is a first inlet and outlet fluid line.
15 . The apparatus of claim 1 , wherein the apparatus is configured for providing the treated fluid for infusion into a patient without exposing the treated fluid to open air.
16 . The apparatus of claim 1 , wherein the apparatus is configured for obtaining the fluid from a patient, treating the fluid, and providing the treated fluid for reinfusion into the patient without exposing the treated fluid to open air.
17 . An apparatus for treating a fluid comprising a biological liquid and/or cells or particles derived from a biological liquid with an activating agent, the apparatus comprising:
a gas-fluid contact device configured to controllably rotate a contact member, the gas-fluid contact device comprising one or more rollers configured to contact an outer surface of the contact member to drive rotation of the contact member, at least one of the one or more rollers driven by a motor, the contact member configured to receive the fluid and having an interior surface configured to be in contact with the received fluid;
a gas inlet line configured to receive a gas comprising the activating agent from a gas source for delivery to the contact member;
one or more first sensors for analyzing a composition of the gas from the gas source to be delivered to the gas-fluid contact device;
a gas outlet line for outputting gas from the contact member;
one or more second sensors for analyzing a composition of the gas output from the gas-fluid contact device; and
a control system configured to:
control rotation of the contact member by the gas-fluid contact device, and control one or both of a flow rate of the gas into the contact member and a composition of the gas flowing into the contact member;
continuously or periodically determine a current total amount of activating agent absorbed by or reacted with the fluid based on measurements from the one or more first sensors and the one or more second sensors;
determine a current rate of activating agent absorption by or reaction with the fluid; and
cease flow of the gas comprising the activating agent to the contact member and/or initiate flow of a purge gas into the contact member before the current total amount of activating agent absorbed by or reacted with the fluid equals a total pre-specified desired amount based, at least in part, on the current total amount of activating agent absorbed by or reacted with the fluid and the current rate of activating agent absorption by or reaction with the fluid such that after all the activating agent has been purged, the total pre-specified desired amount of activating agent absorbed by or reacted with the fluid has been achieved without exceeding a pre-specified limit.
18 . An apparatus for treating a fluid comprising a biological liquid and/or cells or particles derived from a biological liquid with an activating agent, the apparatus comprising:
a gas-fluid contact device configured to controllably rotate a contact member, the contact member configured to receive the fluid and having an interior surface configured to be in contact with the received fluid;
a gas inlet line configured to receive a gas comprising the activating agent from a gas source for delivery to the contact member;
one or more first sensors for analyzing a composition of the gas from the gas source to be delivered to the gas-fluid contact device;
a gas outlet line for outputting gas from the contact member;
one or more second sensors for analyzing a composition of the gas output from the gas-fluid contact device; and
a control system configured to:
control rotation of the contact member by the gas-fluid contact device, and control one or both of a flow rate of the gas into the contact member and a composition of the gas flowing into the contact member;
continuously or periodically determine a current total amount of activating agent absorbed by or reacted with the fluid based on measurements from the one or more first sensors and the one or more second sensors;
determine a current rate of activating agent absorption by or reaction with the fluid; and
cease flow of the gas comprising the activating agent to the contact member and/or initiate flow of a purge gas into the contact member before the current total amount of activating agent absorbed by or reacted with the fluid equals a total pre-specified desired amount based, at least in part, on the current total amount of activating agent absorbed by or reacted with the fluid and the current rate of activating agent absorption by or reaction with the fluid such that after all the activating agent has been purged, the total pre-specified desired amount of activating agent absorbed by or reacted with the fluid has been achieved without exceeding a pre-specified limit,
wherein the apparatus is configured for between 8% and 35% of a volume of the contact member be filled with the fluid during rotation of the contact member.