Surgical adhesives
A composition including a polymerizable monomer with a phosphate or phosphonate function on the one hand and a methacrylate, acrylate, acrylamide or methacrylamide function on the other hand at a concentration of between 5 and 40% by weight relative to the total weight of the composition,—a photoinitiator at a concentration of between 0.5 and 2% by weight, and a photopolymerizable resin.
1 . A composition as a surgical adhesive for adhesion of a material to a non-mineralized biological tissue, adhesion of non-mineralized biological tissues to one another, adhesion of a glue or a substance at the surface of the non-mineralized biological tissue, as a surgical sealant, to seal or plug orifices created by wire or staple suture or by tissue resection, to seal an orifice, an incision or a tear in the non-mineralized biological tissue, as a hemostatic to stop bleeding, as a dressing on the non-mineralized biological tissue to cover and protect a wound, to reinforce the non-mineralized biological tissue, to fix and stabilize the non-mineralized biological tissue comprising:
between 20% and 40% by weight of a polymerizable monomer,
between 0.25% and 2% by weight of a photoinitiator at a concentration comprised between 0.5 and 2% by weight, and
between 50% and 90% by weight of a photopolymerizable resin.
2 . The composition according to claim 1 , wherein said polymerizable monomer is selected from the group consisting of molecules having the CAS number [14206-25-8], [14235-57-5], [86242-61-7], [932019-41-6], [1980781-17-6], [60161-88-8], [87243-97-8], [1980048-95-0], [918802-80-9], [63411-25-6], [1980064-07-0], [22432-83-3], [1980781-08-5], [252210-28-9], [1114567-37-1], [80730-17-2], [518991-74-7], [87243-96-7], [1980062-84-7], [518991-75-8], [252210-30-3], [22432-84-4], [727415-30-7], [727415-31-8], [784139-89-5] or [1194231-98-5] and mixtures thereof.
3 . The composition according to claim 1 , wherein said polymerizable monomer is of formula I
wherein
R2 is H or CH3;
R1, R1′, R1″ are independently of each other a linear polyether radical, a linear or branched C1-C50 aliphatic radical, a C6-C18 aromatic radical, wherein the carbon chain of said radicals may be interrupted by O, S, OCONH and/or may comprise one or more alcohol function(s);
R1′ is H if c=0;
R1″ is H if a=0;
b is 1;
a or c is 1 or 0.
4 . The composition according to claim 3 , wherein a=0, R2=H or CH3 and R′1 and R1 is a linear C1-C12 aliphatic chain.
5 . The composition according to claim 4 , wherein a=0, c=0, R2=CH3 and R1 is a linear C1-C12 aliphatic chain.
6 . The composition according to claim 3 , wherein the polymerizable monomer of formula I is 10-(phosphonooxy) decyl methacrylate.
7 . The composition according to claim 1 , wherein said photoinitiator is configured to induce polymerization under the effect of UV radiation comprised between 350 and 520 nm.
8 . The composition according to claim 1 , wherein said photoinitiator is camphorquinone associated with Ethyl-4-(dimethylamino)benzoate (EDB).
9 . A non-invasive method for covering and protecting a cutaneous lesion, comprising the steps of:
(i) coating the tissue to be treated with a composition according to claim 1 ,
(ii) inducing the polymerisation of said composition.
10 . The composition of claim 1 , wherein the polymerizable monomer further comprises a phosphate function or a phosphonate function.
11 . The composition of claim 1 , wherein the polymerizable monomer further comprises a methacrylate function, an acrylate function, an acrylamide function, or a methacrylamide function.
12 . The composition according to claim 3 , wherein the polymerizable monomer of formula I is bis[2-(methacryloyloxy)ethyl] phosphate.
13 . The composition according to claim 7 , wherein the UV radiation has an irradiance power between 10 mW/cm 2 and 100 mW/cm 2 .
14 . The composition according to claim 13 , wherein the UV radiation has an irradiance power between 17 mW/cm 2 and 92 mW/cm 2 .