IP Library › Granted Patent US 12667646
Granted Patent B2
US 12667646 · App. 18/786,855 · Granted Jun 30, 2026

Engineering mechanically functional human cartilage and method of making same

Inventors: Sarindr Bhumiratana (Oceanside, NY); Gordana Vunjak-Novakovic (New York, NY)
Assignee: The Trustees of Columbia University in the City of New York
A61L27/3612A61F2/30756A61L27/3608A61L27/3834A61L27/425A61L27/46A61L27/50A61L27/56A61F2002/30762A61F2002/30766A61F2/3094A61L2400/06A61L2430/06A61L2430/10
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Quick Facts
Patent No.
US 12667646
App. No.
18/786,855
Granted
Jun 30, 2026
Kind
B2
Abstract

Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.

Claims (17)

1 . An anatomical scaffold comprising:

a porous substrate; and

condensed mesenchymal bodies attached to the porous substrate.

2 . The scaffold of claim 1 , wherein the condensed mesenchymal bodies penetrate the porous substrate.

3 . The scaffold of claim 1 , wherein the condensed mesenchymal bodies form a dense cellular layer disposed on the porous substrate.

4 . The scaffold of claim 3 , wherein the dense cellular layer of condensed mesenchymal bodies and the porous substrate form a stratified structure.

5 . The scaffold of claim 1 , wherein the porous substrate is decellularized bone.

6 . The scaffold of claim 5 , wherein the condensed mesenchymal bodies are interdispersed in pores of the decellularized bone.

7 . The scaffold of claim 1 , wherein the porous substrate comprises calcium phosphate or hydroxyapatite.

8 . A method for generating osteochondral construct, the method comprising:

culturing human mesenchymal stem cells to form condensed mesenchymal bodies; and

attaching the condensed mesenchymal bodies on a porous substrate.

9 . The method of claim 8 , wherein the condensed mesenchymal bodies penetrate the porous substrate.

10 . The method of claim 8 , wherein the condensed mesenchymal bodies form a dense layer on the porous substrate.

11 . The method of claim 8 , wherein the porous substrate is decellularized bone.

12 . The method of claim 11 , wherein the condensed mesenchymal bodies are interdispersed in pores of the decellularized bone.

13 . The method of claim 8 , wherein the porous substrate comprises calcium phosphate or hydroxyapatite.