IP Library Granted Patent US 12667647
Granted Patent B2
US 12667647 · App. 19/230,548 · Granted Jun 30, 2026

Scaffold composite, and preparation method and use thereof

Inventors: Weichao Li (Kunming City, CN); Hongran Ge (Kunming City, CN); Yuncheng Bai (Kunming City, CN); Yayu Zhao (Kunming City, CN); Wen Lei (Kunming City, CN); Chunyan Shen (Kunming City, CN)
Assignee: Kunming University of Science and Technology
A61L27/443
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Quick Facts
Patent No.
US 12667647
App. No.
19/230,548
Granted
Jun 30, 2026
Kind
B2
Abstract

A scaffold composite, and a preparation method and use thereof are provided. The preparation method includes: mixing a graphene oxide (GO) dispersion and a polylactic acid (PLA) dispersion, and subjecting a resulting mixed solution to curing and melt extrusion in sequence to obtain a 3-dimensional (3D)-printable GO/PLA composite wire; subjecting the 3D-printable GO/PLA composite wire to 3D printing to obtain a scaffold; and annealing the scaffold to obtain the scaffold composite.

Claims (21)

1 . A method for preparing a scaffold composite, comprising:

mixing a graphene oxide (GO) dispersion and a polylactic acid (PLA) dispersion, and subjecting a resulting mixed dispersion to curing and melt extrusion in sequence to obtain a 3-dimensional (3D)-printable GO/PLA composite wire;

subjecting the 3D-printable GO/PLA composite wire to 3D printing to obtain a scaffold; and

annealing the scaffold to obtain the scaffold composite;

wherein the annealing is conducted in an oven;

the annealing is conducted at an oven temperature of 120° C. for 2 h;

the melt extrusion is conducted at a screw speed of 16 rotations/minute (r/min); and

wherein a mass ratio of GO to PLA in the 3D-printable GO/PLA composite wire is in a range of 0.001:1 to 0.0025:1.

2 . The method of claim 1 , wherein a solvent in the GO dispersion and a solvent in the PLA dispersion comprise independently one or more selected from the group consisting of difluoromethane, fluorobenzene, N, N-dimethylacetamide (DMAc), and N, N-dimethylformamide (DMF).

3 . The method of claim 1 , wherein the mixing is conducted under stirring at a temperature of 28° C. to 35° C. for 40 minutes to 80 minutes; and

the PLA dispersion is prepared by mixing PLA with an organic solvent at a temperature of 28° C. to 35° C. for 90 minutes to 180 minutes.

4 . The method of claim 1 , wherein the curing is conducted by vacuum drying; and

the vacuum drying is conducted at a temperature of 50° C. to 70° C. for 24 hours.

5 . The method of claim 1 , wherein the melt extrusion is conducted at a die temperature of 190° C. to 210° C.

6 . A scaffold composite prepared by the method of claim 1 .

7 . The scaffold composite of claim 6 , wherein a solvent in the GO dispersion and a solvent in the PLA dispersion comprise independently one or more selected from the group consisting of difluoromethane, fluorobenzene, N, N-dimethylacetamide (DMAc), and N, N-dimethylformamide (DMF).

8 . The scaffold composite of claim 6 , wherein the mixing is conducted under stirring at a temperature of 28° C. to 35° C. for 40 minutes to 80 minutes; and

the PLA dispersion is prepared by mixing PLA with an organic solvent at a temperature of 28° C. to 35° C. for 90 minutes to 180 minutes.

9 . The scaffold composite of claim 6 , wherein the curing is conducted by vacuum drying; and

the vacuum drying is conducted at a temperature of 50° C. to 70° C. for 24 hours.

10 . The scaffold composite of claim 6 , wherein the melt extrusion is conducted at a die temperature of 190° C. to 210° C.