Scaffold composite, and preparation method and use thereof
A scaffold composite, and a preparation method and use thereof are provided. The preparation method includes: mixing a graphene oxide (GO) dispersion and a polylactic acid (PLA) dispersion, and subjecting a resulting mixed solution to curing and melt extrusion in sequence to obtain a 3-dimensional (3D)-printable GO/PLA composite wire; subjecting the 3D-printable GO/PLA composite wire to 3D printing to obtain a scaffold; and annealing the scaffold to obtain the scaffold composite.
1 . A method for preparing a scaffold composite, comprising:
mixing a graphene oxide (GO) dispersion and a polylactic acid (PLA) dispersion, and subjecting a resulting mixed dispersion to curing and melt extrusion in sequence to obtain a 3-dimensional (3D)-printable GO/PLA composite wire;
subjecting the 3D-printable GO/PLA composite wire to 3D printing to obtain a scaffold; and
annealing the scaffold to obtain the scaffold composite;
wherein the annealing is conducted in an oven;
the annealing is conducted at an oven temperature of 120° C. for 2 h;
the melt extrusion is conducted at a screw speed of 16 rotations/minute (r/min); and
wherein a mass ratio of GO to PLA in the 3D-printable GO/PLA composite wire is in a range of 0.001:1 to 0.0025:1.
2 . The method of claim 1 , wherein a solvent in the GO dispersion and a solvent in the PLA dispersion comprise independently one or more selected from the group consisting of difluoromethane, fluorobenzene, N, N-dimethylacetamide (DMAc), and N, N-dimethylformamide (DMF).
3 . The method of claim 1 , wherein the mixing is conducted under stirring at a temperature of 28° C. to 35° C. for 40 minutes to 80 minutes; and
the PLA dispersion is prepared by mixing PLA with an organic solvent at a temperature of 28° C. to 35° C. for 90 minutes to 180 minutes.
4 . The method of claim 1 , wherein the curing is conducted by vacuum drying; and
the vacuum drying is conducted at a temperature of 50° C. to 70° C. for 24 hours.
5 . The method of claim 1 , wherein the melt extrusion is conducted at a die temperature of 190° C. to 210° C.
6 . A scaffold composite prepared by the method of claim 1 .
7 . The scaffold composite of claim 6 , wherein a solvent in the GO dispersion and a solvent in the PLA dispersion comprise independently one or more selected from the group consisting of difluoromethane, fluorobenzene, N, N-dimethylacetamide (DMAc), and N, N-dimethylformamide (DMF).
8 . The scaffold composite of claim 6 , wherein the mixing is conducted under stirring at a temperature of 28° C. to 35° C. for 40 minutes to 80 minutes; and
the PLA dispersion is prepared by mixing PLA with an organic solvent at a temperature of 28° C. to 35° C. for 90 minutes to 180 minutes.
9 . The scaffold composite of claim 6 , wherein the curing is conducted by vacuum drying; and
the vacuum drying is conducted at a temperature of 50° C. to 70° C. for 24 hours.
10 . The scaffold composite of claim 6 , wherein the melt extrusion is conducted at a die temperature of 190° C. to 210° C.