Medicament preparation devices, methods, and systems

1 . A system for preparing a medicament for use by a medicament user, comprising:

a proportioning machine having a controller, a pumping actuator, and clamping actuators configured to engage a fluid circuit, the fluid circuit having a pumping portion that engages with the pumping actuator and clamping portions that engage with respective ones of the clamping actuators of the proportioning machine;

the fluid circuit having an empty mixing container attached to the fluid circuit, a first pre-attached concentrate container, and a second pre-attached concentrate container;

a first detachable container having a first concentrated medicament therein;

a second detachable container having a second concentrated medicament therein;

the proportioning machine being configured to flow a fluid from the mixing container into and out of the mixing container to circulate the fluid;

the proportioning machine being configured to flow water and the first and second concentrated medicaments into said mixing container to dilute the first and second concentrated medicaments to make a ready-to-use medicament;

the controller being configured to regulate a clamp on a return line leading to said mixing container to generate a predefined pressure in an outlet line of the fluid circuit which is attachable to an external user of the ready-to-use medicament; and

the predefined pressure being maintained in the outlet line by pressure feedback control, wherein

the controller is configured to control the pumping actuator and the clamping actuators to convey at least one of the first concentrated medicament from the first detachable container and the second concentrated medicament from the second detachable container into a drain line, and to hold the at least one of the first concentrated medicament and the second concentrated medicament in the drain line to inhibit bacterial growth in the drain line.

2 . The system of claim 1 , wherein the controller is further configured to control the pumping actuator and the clamping actuators to convey the first concentrated medicament from the first detachable container through a sterilizing filter into the first pre-attached concentrate container.

3 . The system of claim 2 , wherein the pumping actuator and the clamping actuators include a peristaltic pump, and the peristaltic pump operates in a first direction when the peristaltic pump conveys the first concentrated medicament into the first pre-attached concentrate container.

4 . The system of claim 3 , wherein the controller is further configured to control the peristaltic pump to operate in a second direction, opposite to the first direction, when the first concentrated medicament is conveyed into the mixing container.

5 . The system of claim 4 , wherein the first concentrated medicament is conveyed from the first pre-attached concentrate container into the mixing container.

6 . The system of claim 1 , wherein the controller is further configured to control the pumping actuator and the clamping actuators to convey the second concentrated medicament from the second detachable container through a sterilizing filter into the second pre-attached concentrate container.

7 . The system of claim 6 , wherein the pumping actuator includes a peristaltic pump, and the peristaltic pump operates in a first direction when the peristaltic pump conveys the second concentrated medicament into the second pre-attached concentrate container.

8 . The system of claim 7 , wherein the controller is further configured to control the peristaltic pump to operate in a second direction, opposite to the first direction, when the second concentrated medicament is conveyed into the mixing container.

9 . The system of claim 8 , wherein the second concentrated medicament is conveyed from the second pre-attached concentrate container into the mixing container.

10 . A system for preparing a medicament for use by a medicament user, comprising: a proportioning machine having a controller, a pumping actuator, and clamping actuators configured to engage a fluid circuit, the fluid circuit having a pumping portion that engages with the pumping actuator and clamping portions that engage with respective ones of the clamping actuators of the proportioning machine;

the fluid circuit having an empty mixing container attached to the fluid circuit, a first pre-attached concentrate container, and a second pre-attached concentrate container;

a first detachable container having a first concentrated medicament therein;

a second detachable container having a second concentrated medicament therein;

the proportioning machine being configured to flow a fluid from the mixing container into and out of the mixing container to circulate the fluid;

the proportioning machine being configured to flow water and the first and second concentrated medicaments into said mixing container to dilute the first and second concentrated medicaments to make a ready-to-use medicament;

the controller being configured to regulate a clamp on a return line leading to said mixing container to generate a predefined pressure in an outlet line of the fluid circuit which is attachable to an external user of the ready-to-use medicament; and

the predefined pressure being maintained in the outlet line by pressure feedback control, wherein the controller is further configured to control the clamping portions, the pumping actuator, and the clamping actuators to convey the first concentrated medicament from the first detachable container through a sterilizing filter into the first pre-attached concentrate container, wherein

the pumping actuator includes a peristaltic pump, and the peristaltic pump operates in a first direction when the peristaltic pump conveys the first concentrated medicament into the first pre-attached concentrate container,

the controller is further configured to control the peristaltic pump to operate in a second direction, opposite to the first direction, when the first concentrated medicament is conveyed into the mixing container,

the first concentrated medicament is conveyed from the first pre-attached concentrate container into the mixing container, and

the peristaltic pump operates in the second direction when water is conveyed into the mixing container.

11 . The system of claim 9 , wherein the peristaltic pump operates in the second direction when water is conveyed into the mixing container.

12 . The system of claim 1 , wherein the first and second concentrated medicaments and the ready-to-use medicament are for peritoneal dialysis fluid.

13 . The system of claim 1 , wherein the external user of the ready-to-use medicament is a peritoneal dialysis cycler.

14 . The system of claim 1 , wherein the mixing container is removably connected to the fluid circuit by connectors.

15 . A system for preparing a medicament for use by a medicament user, comprising:

a proportioning machine having a controller, a pumping actuator, and clamping actuators configured to engage a fluid circuit, the fluid circuit having a pumping portion that engages with the pumping actuator and clamping portions that engage with respective ones of the clamping actuators of the proportioning machine;

the fluid circuit having an empty mixing container attached to the fluid circuit, a first pre-attached concentrate container, and a second pre-attached concentrate container;

a first detachable container having a first concentrated medicament therein;

a second detachable container having a second concentrated medicament therein;

the proportioning machine being configured to flow a fluid from the mixing container into and out of the mixing container to circulate the fluid;

the proportioning machine being configured to flow water and the first and second concentrated medicaments into said mixing container to dilute the first and second concentrated medicaments to make a ready-to-use medicament;

the controller being configured to regulate a clamp on a return line leading to said mixing container to generate a predefined pressure in an outlet line of the fluid circuit which is attachable to an external user of the ready-to-use medicament; and

the predefined pressure being maintained in the outlet line by pressure feedback control, wherein

the controller is further configured to control the pumping actuator and the clamping actuators to convey the second concentrated medicament from the second detachable container through a sterilizing filter into the second pre-attached concentrate container,

the pumping actuator includes a peristaltic pump, and the controller is configured to control the peristaltic pump to operate in a first direction when the peristaltic pump conveys the second concentrated medicament into the second pre-attached concentrate container, and

the controller is further configured to control the peristaltic pump to operate in a second direction, opposite to the first direction, when the second concentrated medicament is conveyed from the second pre-attached concentrate container into the mixing container.