Integrated insulin delivery system having safety features to prevent hypoglycemia
Systems comprising: an analyte sensor for providing an analyte signal representative of an analyte level; a controller in data communication with the analyte sensor and programmed to provide a recommended medication dose based on the analyte level and a medication type, the controller comprising a user interface for inputting the medication type; and a model-based safety mechanism integrated with the controller for evaluating the recommended medication dose. Wherein the model-based safety mechanism overrides the recommended medication dose and provides a safety medication dose when the model-based safety mechanism detects a risk of insulin deprivation.
1 . An insulin pump for administering a dose of insulin for a user, comprising:
a processor configured to:
cause the insulin pump to administer the dose of insulin to the user, wherein the insulin pump is configured to be worn externally on the user, wherein the insulin pump comprises a reservoir and a cannula, and a communication device:
transmit insulin delivery information to a handheld device;
receive a delivery control signal;
administer, while a current basal rate is suspended, the dose of insulin as an instantaneous bolus based on the delivery control signal; and
resume the current basal rate after the instantaneous bolus is completed;
an integrated control unit with a selectable button, wherein the integrated control unit is configured to:
detect activation of the selectable button; and
transmit, responsive to detecting activation of the selectable button, the delivery control signal to the processor, and wherein the delivery control signal comprises a bolus amount to be administered with the instantaneous bolus.
2 . The system of claim 1 , wherein the control unit comprises a memory configured to store a closed loop algorithm, and wherein the closed loop control algorithm comprises one of a fully closed-loop control algorithm or a semi closed-loop control algorithm.
3 . The system of claim 1 , wherein the insulin pump is implemented as a patch pump.
4 . The system of claim 1 , wherein the analyte sensor is a continuous glucose monitoring (CGM) sensor and the analyte levels comprise continuously monitored analyte data from the CGM sensor.
5 . The system of claim 1 , wherein to predict the future glucose levels, the control unit is further configured to:
detect a sensor signal anomaly in the analyte levels from the analyte sensor; and
adjust, based on the sensor signal anomaly, a closed loop system parameter to maintain the analyte at the target level.
6 . The system of claim 5 , wherein the closed loop system parameter comprises one of a target glucose range, a variance of a glucose estimate, a calibration correction factor, and a factor for terminating closed-loop operation of the control unit.
7 . The system of claim 1 , wherein the target level comprises a range of target analyte values.
8 . The system of claim 1 , wherein the control unit further comprises a memory configured to store a closed loop control algorithm configured to maintain the analyte level at the target level, and wherein the closed loop control algorithm is one of a fully closed-loop diabetes control algorithm and a semi closed-loop diabetes control algorithm.
9 . The system of claim 1 , wherein the delivery control signal includes a parameter associated with one or more of an insulin bolus amount, a bolus type, an insulin bolus delivery time, and an insulin bolus delivery interval.
10 . The system of claim 1 , wherein the control unit is configured to automatically provide the delivery control signal to the insulin pump based on the future glucose level.