Therapeutic treatment device with braided microvalve occluder

1 . A therapeutic device for delivery of a therapeutic agent within a vessel of a patient during a vascular procedure, the vessel having a vessel wall, comprising:

a) a flexible catheter sized for introduction into the vessel, the catheter having a proximal end and a distal end, an outer surface, a lumen extending between the proximal and distal ends and opening at a distal orifice; and

b) a filamentary construct mounted on the outer surface of the catheter adjacent the distal end of the catheter, the construct comprising,

i) a plurality of elastic filamentary strands in a tubular braid extending from a proximal end to a distal end, the plurality of elastic filamentary strands having proximal portions, central portions, and distal portions,

the distal portions extend from the central portions distally and taper to the distal end of the tubular braid, the distal end longitudinally fixed to the outer surface of the catheter at a first location proximal of the distal orifice,

the central portions extending proximally from the distal portions and biased to extend radially outward from the outer surface of the catheter, and

the proximal portions inverting relative to the central portions to extend distally and radially inward onto the outer surface, and coupled circumferentially about the outer surface of the catheter at a second location proximally displaced from the first location, and

ii) a material provided onto the proximal portions of the plurality of elastic filamentary strands and at least a portion of the central portions of the plurality of elastic filamentary strands, the material forming a barrier to passage of the therapeutic agent.

2 . The therapeutic device of claim 1 , wherein the proximal portions of the plurality of elastic filamentary strands are longitudinally fixed to the second location.

3 . The therapeutic device of claim 1 , wherein the plurality of elastic filamentary strands are independently movable relative to each other between the proximal and distal ends of the tubular braid.

4 . The therapeutic device of claim 1 , wherein the plurality of elastic filamentary strands comprise a nickel titanium alloy.

5 . The therapeutic device of claim 1 , wherein the material comprises a polymeric material.

6 . The therapeutic device of claim 5 , wherein the polymeric material comprises a fluid impermeable membrane.

7 . The therapeutic device of claim 5 , wherein the polymeric material extends between and across the plurality of elastic filamentary strands.

8 . The therapeutic device of claim 5 , wherein the polymeric material comprises an elastomeric polymer.

9 . The therapeutic device of claim 8 , wherein the elastomeric polymer comprises a thermoplastic urethane.

10 . The therapeutic device of claim 8 , wherein the elastomeric polymer is a silicone.

11 . The therapeutic device of claim 1 , wherein the filamentary construct defines spaces between the distal portions of the plurality of elastic filamentary strands for fluid communication into an interior of the filamentary construct.

12 . A therapeutic device for delivery of a therapeutic agent within a vessel of a patient during a vascular procedure, the vessel having a vessel wall, comprising:

a) a flexible catheter sized for introduction into the vessel, the catheter having a proximal end and a distal end, an outer surface, a lumen extending between the proximal and distal ends and opening at a distal orifice; and

b) a filamentary construct mounted on the outer surface of the catheter adjacent the distal end of the catheter, the construct comprising,

i) a plurality of elastic filamentary strands in a tubular braid extending from a proximal end to a distal end, the plurality of elastic filamentary strands having proximal portions, central portions, and distal portions,

the distal portions extend distally from the central portions and taper to the distal end of the tubular braid, the distal end longitudinally fixed to the outer surface of the catheter at a first location proximal of the distal orifice,

the proximal portions inverting relative to the central portions to extend distally to a second location on the outer surface proximal of the first location, the proximal end longitudinally fixed to the outer surface of the catheter at the second location, and

the central portions extending radially from the catheter; and

ii) a fluid impermeable material provided onto at least the proximal portions of the plurality of elastic filamentary strands and at least a portion of the central portions of the plurality of elastic filamentary strands, the fluid impermeable material forming a barrier to passage of the therapeutic agent.

13 . The therapeutic device of claim 12 , wherein the plurality of elastic filamentary strands are independently movable relative to each other between the proximal and distal ends of the tubular braid.

14 . The therapeutic device of claim 12 , wherein the plurality of elastic filamentary strands comprise a nickel titanium alloy.

15 . The therapeutic device of claim 12 , wherein the fluid impermeable material comprises a polymeric material.

16 . The therapeutic device of claim 15 , wherein the polymeric material comprises a membrane.

17 . The therapeutic device of claim 15 , wherein the polymeric material extends between and across the plurality of elastic filamentary strands.

18 . The therapeutic device of claim 15 , wherein the polymeric material comprises an elastomeric polymer.

19 . The therapeutic device of claim 18 , wherein the elastomeric polymer comprises a thermoplastic urethane.

20 . The therapeutic device of claim 18 , wherein the elastomeric polymer is a silicone.

21 . The therapeutic device of claim 12 , wherein the filamentary construct defines spaces between the distal portions of the plurality of elastic filamentary strands for fluid communication into an interior of the filamentary construct.