IP Library › Granted Patent US 12667735
Granted Patent B2
US 12667735 · App. 17/621,317 · Granted Jun 30, 2026

Methods for reducing pain during photodynamic therapy of actinic keratosis

Inventor: Edward V. Maytin (Cleveland, OH)
Assignee: Sun Pharmaceutical Industries, Inc.
A61N5/062A61K41/0061A61P29/00A61N2005/0663
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Quick Facts
Patent No.
US 12667735
App. No.
17/621,317
Granted
Jun 30, 2026
Kind
B2
Abstract

This present invention and its embodiments relates to methods for reducing pain during photodynamic therapy of actinic keratosis. The present invention also relates to methods of treating actinic keratosis with reduced pain during photodynamic therapy of actinic keratosis.

Claims (23)

1 . A method of reducing pain during a photodynamic therapy of actinic keratoses comprising:

(a) applying a pharmaceutical composition comprising 20% w/v solution of 5-aminolevulinic acid on an affected area of skin of a patient;

(b) illuminating the affected area with a blue light source applied at an intensity of 10 mW/cm 2 with a pre-illumination gap of no more than 10 minutes; and

(c) maintaining the illumination for at least 45 minutes;

wherein the method does not include a pre-treatment preparation.

2 . The method according to claim 1 , wherein the blue light source delivers a light having a wavelength of 417 nm±5 nm.

3 . The method according to claim 1 , wherein the actinic keratoses is of face and/or scalp.

4 . The method according to claim 1 , wherein the illumination of step (c) is carried out for at least 60 minutes.

5 . The method according to claim 1 , wherein the method results in a significantly reduced VAS pain score as compared to a photodynamic therapy with a pre-illumination gap of at least 60 minutes.

6 . The method according to claim 5 , wherein the resulting VAS pain score is less than 1.0.

7 . The method according to claim 5 , wherein the resulting VAS pain score is 0.5+0.5.

8 . The method according to claim 5 , wherein the resulting VAS pain score is 0.0.

9 . A method of treating actinic keratoses comprising:

(a) applying a pharmaceutical composition comprising 20% w/v solution of 5-aminolevulinic acid on an affected area of skin of a patient;

(b) illuminating the affected area with a blue light source applied at an intensity of 10 mW/cm 2 with a pre-illumination gap of no more than 10 minutes; and

(c) maintaining the illumination for at least 45 minutes;

wherein the method does not include a pre-treatment preparation.

10 . The method according to claim 9 , wherein the blue light source delivers a light having a wavelength of 417 nm±5 nm.

11 . The method according to claim 9 , wherein the illumination of step (c) is carried out for at least 60 minutes.

12 . The method according to claim 9 , wherein the method results in a significantly reduced VAS pain score as compared to a photodynamic therapy with a pre-illumination gap of at least 60 minutes.

13 . The method according to claim 12 , wherein the resulting VAS pain score is less than 1.0.

14 . The method according to claim 12 , wherein the resulting VAS pain score is 0.5±0.5.

15 . The method according to claim 12 , wherein the resulting VAS pain score is 0.0.