Microfluidic flow channel structure and microfluidic chip
A microfluidic flow channel structure and a microfluidic chip are described. The microfluidic flow channel structure includes a main chamber, wherein the main chamber includes at least two division zones and a reaction zone, and the at least two division zones are respectively connected with the reaction zone, wherein each division zone includes a first division wall, and the first division wall is provided with an opening for liquid inlet; a diversion structure is arranged at the opening of at least one division zone, and the diversion structure at least includes a first diversion wall, which is arranged opposite the first division wall; a first division channel is formed between the first diversion wall and the first division wall, and the first division channel includes at least two liquid outlets.
1 . A microfluidic flow channel structure, comprising a main chamber, the main chamber comprises at least two division zones and a reaction zone, and the at least two division zones are respectively connected with the reaction zone, wherein:
a division zone of the at least two division zones comprises a first division wall, and the first division wall is provided with an opening for liquid inlet;
a diversion structure is arranged at the opening of the division zone of the at least two division zones, and the diversion structure at least comprises a first diversion wall, which is arranged opposite the first division wall;
a first division channel is formed between the first diversion wall and the first division wall;
the opening serves as a liquid inlet of the first division channel, and the first division channel comprises at least two liquid outlets;
each division zone is in a single-input and double-output structure;
the at least two division zones are adjacent to form four liquid paths for sample liquid to enter the reaction zone;
the reaction zone is a conical reaction zone, and the conical reaction zone is in an outlet region of the single-input and double-output structure; and
the microfluidic flow channel structure further comprises a liquid outlet zone, and the liquid outlet zone comprises a plurality of liquid outlet channels, and each liquid outlet channel is connected with the reaction zone.
2 . The microfluidic flow channel structure according to claim 1 , wherein
the division zone of the at least two division zones further comprises a second division wall,
one end of the first division wall is connected with the second division wall,
the diversion structure further comprises a second diversion wall,
one end of the first diversion wall is connected with the second diversion wall,
the second diversion wall is arranged opposite the second division wall,
a second division channel is formed between the second diversion wall and the second division wall, and
the second division channel is communicated with the first division channel.
3 . The microfluidic flow channel structure according to claim 2 , wherein
the division zone of the at least two division zones further comprises a third division wall,
one end of the first division wall away from the second division wall is connected with the third division wall,
the diversion structure further comprises a third diversion wall,
one end of the first diversion wall away from the second diversion wall is connected with the third diversion wall,
the third diversion wall is arranged opposite the third division wall, and
a third division channel is formed between the third diversion wall and the third division wall; and
the third division channel is communicated with the first division channel.
4 . The microfluidic flow channel structure according to claim 3 , wherein
for any two adjacent division zones, the third diversion wall of the first division zone and the third diversion wall of the second division zone share a division wall structure, and
a side of the division wall structure facing the first division zone serves as the third division wall of the first division zone, and a side of the division wall structure away from the first division zone serves as the third division wall of the second division zone.
5 . The microfluidic flow channel structure according to claim 4 , wherein,
in a plane parallel to the microfluidic flow channel structure, the third division wall is arcuate or linear and the third diversion wall is arcuate or linear.
6 . The microfluidic flow channel structure according to claim 4 , wherein
the division wall structure has a U-shaped cross section in a plane parallel to the microfluidic flow channel structure.
7 . The microfluidic flow channel structure according to claim 3 , wherein,
in a plane parallel to the microfluidic flow channel structure, the third division wall is arcuate or linear and the third diversion wall is arcuate or linear.
8 . The microfluidic flow channel structure according to claim 3 , wherein
in a plane parallel to the microfluidic flow channel structure, the second division wall is arcuate or linear and the second diversion wall is arcuate or linear.
9 . The microfluidic flow channel structure according to claim 2 , wherein
for any two adjacent division zones, one end of the first division wall of the first division zone is connected with one end of the first division wall of the second division zone, the other end of the first division wall of the first division zone is connected with the second division wall of the second division zone, and the other end of the first division wall of the second division zone is connected with the second division wall of the second division zone;
the division zone of the at least two division zones further comprise a third diversion wall, and one end of the first diversion wall away from the second diversion wall is connected with the third diversion wall; and
a third division channel is formed between the third diversion wall of the first division zone and the third diversion wall of the second division zone, and the third division channel is communicated with the first division channel of the first division zone and the first division channel of the second division zone.
10 . The microfluidic flow channel structure according to claim 2 , wherein
in a plane parallel to the microfluidic flow channel structure, the second division wall is arcuate or linear and the second diversion wall is arcuate or linear.
11 . The microfluidic flow channel structure according to claim 2 , wherein
the second division wall has a U-shaped cross section in a plane parallel to the microfluidic flow channel structure.
12 . The microfluidic flow channel structure according to claim 2 , wherein
the second division wall is provided with an opening.
13 . The microfluidic flow channel structure according to claim 2 , wherein
in a plane parallel to the microfluidic flow channel structure, the first division wall is arcuate, linear or bending, and the first diversion wall is arcuate, linear or bending.
14 . The microfluidic flow channel structure according to claim 1 , wherein
in a plane parallel to the microfluidic flow channel structure, the first division wall is arcuate, linear or bending, and the first diversion wall is arcuate, linear or bending.
15 . The microfluidic flow channel structure according to claim 1 , wherein
the reaction zone comprises a first reaction wall and a second reaction wall, wherein
the first reaction wall and the second reaction wall are oppositely arranged to form a reaction zone inlet, a reaction channel and a reaction zone outlet, and
the width of the reaction zone channel gradually decreases from the reaction zone inlet to the reaction zone outlet.
16 . The microfluidic flow channel structure according to claim 15 , wherein in the plane parallel to the microfluidic flow channel structure,
the first reaction wall and the second reaction wall are arcuate; or
the first reaction wall and the second reaction wall are linear or bending; or
the first reaction wall comprises at least two reaction wall sub-sections connected in sequence, wherein at least one reaction wall sub-section is arcuate and at least one reaction wall sub-section is linear; the second reaction wall comprises at least two reaction wall sub-sections connected in sequence, wherein at least one reaction wall sub-section is arcuate and at least one reaction wall sub-section is linear.
17 . The microfluidic flow channel structure according to claim 1 , further comprising,
at least two mixing zones, each mixing zone is connected with at least one division zone;
each said mixing zone comprises a liquid inlet port, a mixing flow channel and a liquid outlet port; and
the liquid inlet ports of the at least two mixing zones are communicated, and the liquid outlet port of each mixing zone is communicated with the opening in the first division wall of one division zone.
18 . The microfluidic flow channel structure according to claim 17 , wherein,
the mixing flow channel is a serpentine channel.
19 . A microfluidic chip comprising the microfluidic flow channel structure according to claim 1 .