Modified forms of ambroxol for therapeutic use
The invention relates to analog forms of ambroxol and related compounds, compositions comprising same, and methods of preventing and/or treating various diseases and medical conditions involving the administration of analogs of ambroxol and related compounds.
1 . A compound according to Formula I:
wherein
indicates that the associated R or X group can be attached to any available carbon atom on the phenyl ring,
R a is hydroxyl (OH),
R b is H,
R c and R d are each independently selected from H or a C 1-3 alkyl or R c and R d are each part of a 4, 5, 6 or 7 membered ring structure that connects R c and R d ,
each of R 1 to R 14 is independently selected from H and D,
X 1 and X 2 are independently selected from F, Cl, Br, and I, with the proviso that X 1 and X 2 are not both Br; or a pharmaceutically acceptable salt, solvate or prodrug thereof.
2 . The compound according to claim 1 having the following Formula Ia:
3 . The compound according to claim 1 wherein X 1 and X 2 are both F.
4 . The compound according to claim 2 wherein X 1 and X 2 are both F.
5 . The compound according to claim 1 wherein X 1 and X 2 are both Cl.
6 . The compound according to claim 2 , wherein X 1 and X 2 are both Cl.
7 . The compound according to claim 1 , wherein X 1 and X 2 are both I.
8 . The compound according to claim 1 , wherein at least one of R 1 to R 14 is D.
9 . The compound according to claim 1 , wherein R 11 or R 12 is D.
10 . The compound of claim 1 , as part of a composition comprising a pharmaceutically acceptable carrier.
11 . The compound of claim 10 , wherein the composition is a liquid oral pharmaceutical composition.
12 . The compound of claim 10 , wherein the compound of Formula I is in the form of granules having a granular core comprising from about 60 to about 97 weight percent of an active pharmaceutical ingredient and from about 3 to about 40 weight percent of the excipient, wherein the weight percent is based on the total weight of the granular core.
13 . The compound of claim 10 , wherein the compound of Formula I is in the form of granules having a granular core comprising from about 60 to about 97 weight percent of an active pharmaceutical ingredient and from about 3 to about 40 weight percent of the excipient, wherein the weight percent is based on the total weight of the granular core; wherein the granule core is coated with (iv) a water-soluble seal coating in an amount to provide from about 0.5 to about 5 percent weight gain, and (v) an enteric coating in an amount to provide from about 0.5 to about 50 percent weight gain.
14 . A method of preventing and/or treating a disease or medical condition in a subject selected from the group consisting of respiratory diseases and conditions, lysosomal storage disorders (LSDs), and neurological diseases and conditions, said method comprising administering to the subject an effective amount of a compound according to claim 1 .
15 . The method according to claim 14 , wherein the disease or medical condition to be prevented and/or treated is a bronchopulmonary disease, or is Gaucher's disease, Pompe disease or Fabry disease, or is Parkinson's disease, dementia with Lewy bodies, Alzheimer's Disease (AD), Huntington's disease (HD), Amyotrophic Lateral Sclerosis (ALS) (Lou Gehrig's Disease), Frontotemporal Dementia (FTD), Pick's Disease, or Gaucher's Disease.
16 . The method according to claim 14 , wherein the method is for extending life expectancy of a subject, or for treating, inhibiting or reducing aging of a subject, or for treating, inhibiting or reducing an age-related symptom or an age-related disease in a subject, or for increasing the healthspan, lifespan and/or mental acuity of a subject.
17 . The method of claim 14 , wherein said method further comprises administration of one or more suitable anti-beta amyloid antibody or fragment thereof.
18 . The method of claim 17 , wherein the subject is selected by assaying for a biomarker indicative of an at-risk patient or patient in an early stage of development of AD or other amyloid diseases associated with pathological protein misfolding, aggregation and deposition (including Parkinson's disease (PD), Huntington's disease (HD), Amyotrophic Lateral Sclerosis (ALS) (Lou Gehrig's Disease), Pick's Disease, Gaucher's Disease and Frontotemporal degeneration (FTD) disease.
19 . The method according to claim 18 , wherein the subject is selected by assaying for a phosphorylated tau protein (p-tau) indicative of a patient at-risk of AD or a patient in an early stage of development of AD.
20 . The method according to claim 17 , wherein the subject is selected by genotyping of at least one gene or locus indicative of a patient at-risk of AD or other diseases associated with pathological protein misfolding, aggregation and deposition (including Parkinson's disease (PD), Huntington's disease (HD), Amyotrophic Lateral Sclerosis (ALS) (Lou Gehrig's Disease), Pick's Disease, Gaucher's Disease and Frontotemporal degeneration (FTD)) disease.
21 . The method according to claim 20 , wherein the subject is selected by genotyping the ApoE gene or by assaying for p-tau217, p-tau181, p-tau231, p-tau235, and/or N3pG.
22 . The method according to claim 21 , wherein the subject is selected by genotyping for the ε4 allele of the ApoE gene, or by assaying for p-tau217, p-tau181, p-tau231, p-tau235, and/or N3pG.
23 . The method of claim 17 , wherein the compound is administered to the subject in a daily dosage selected from a dosage that:
(i) provides a peak concentration in serum of the subject that is greater than 1 μM such as, for example, 2-50 μM, 2-25 μM or 10-20 μM; or
(ii) provides a peak concentration in brain tissue of the subject that is greater than 3 μM such as, for example, 5-50 μM, 5-25 μM or 10-20 μM; or
(iii) is in the range of about 250-1000 mg/day, 750-1000 mg/day, 1000-2000 mg/day, 1000-1500 mg/day or 1500-2000 mg/day.
24 . The compound according to claim 1 , wherein R 1 is D.
25 . The compound of claim 1 , wherein the C 1-3 alkyl is CH 3 or CH 2 CH 3 ).
26 . The compound of claim 1 , wherein the membered ring structure is —R c —N—R d —(CH2) n — where n is an integer selected from 1, 2, 3 and 4.