Compounds for drug delivery across blood-brain barrier
Compounds disclosed herein have been shown to bind to the transferrin receptor making them capable of crossing the blood-brain barrier (BBB) and useful for treating diseases or disorders of the brain, such as cancer, ischemic stroke, Alzheimer's disease, or Parkinson's disease.
1 . A method for the delivery of an agent to the brain in a subject comprising administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a pharmaceutically acceptable excipient, carrier, buffer, stabilizer, or mixture thereof, wherein the composition comprises a compound capable of crossing the blood-brain barrier and an agent, wherein the compound is linked to the agent, and wherein the compound has a structure of:
2 . The method of claim 1 , wherein the subject has a disease or disorder of the brain, and wherein the disease or disorder of the brain is cancer, ischemic stroke, Alzheimer's disease, or Parkinson's disease.