Cell-penetrating peptide and use thereof
The present disclosure relates to novel cell penetrating peptides and uses thereof. Since 12 types of cell-penetrating peptides according to the present disclosure were confirmed to have excellent cell permeability and an excellent substance delivery effect in vitro and in vivo, the cell-penetrating peptides are expected to be useful in the field of research, and in the field of diagnosis or treatment of various diseases, by being capable of effectively delivering a substance with biological activity into the body, such as cells and tissues.
1 . An in vivo method of substance delivery, comprising treating cells with a complex comprising a cell-penetrating peptide and a biologically active material conjugated to a terminal of the cell-penetrating peptide, wherein the cell-penetrating peptide consists of any one amino acid sequence selected from the group consisting of SEQ ID NOs: 1 to 12.
2 . The in vivo method of substance delivery of claim 1 , wherein the cell is any one selected from the group consisting of brain endothelial cells, cancer cells, blood cells, lymphocytes, immune cells, stem cells, induced pluripotent stem cells (iPSCs), neural stem cells (NSCs), T cells, B cells, natural killer cells (NK cells), macrophages, microglia, neurons, astrocytes, and muscle cells.