Bifunctional protein against PD-1 and TGF-β
Provided in the present disclosure are a bifunctional protein which can bind to PD-1 (programmed death receptor-1) and TGF-β (transforming growth factor-β), the medical use of the bifunctional protein, and a preparation method therefor.
1 . A bifunctional protein, comprising a PD-1 (programmed death receptor-1) binding moiety and a TGF-β (transforming growth factor-β) binding moiety, wherein the bifunctional protein comprises: (1) two identical first polypeptides, the amino acid sequence of the first polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 13; and (2) two identical second polypeptides, the amino acid sequence of the second polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 14.
2 . A pharmaceutical composition, comprising the bifunctional protein according to claim 1 and a pharmaceutically acceptable excipient, diluent or carrier.
3 . A bifunctional protein, comprising a PD-1 (programmed death receptor-1) binding moiety and a TGF-β (transforming growth factor-β) binding moiety, wherein the bifunctional protein comprises: a first polypeptide, the amino acid sequence of the first polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 13; and a second polypeptide, the amino acid sequence of the second polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 14.