Combination treatment by administering a recombinant apyrase protein in conjunction with a P2Y

1 . A method of treating an ischemic event in a patient, the method comprising sequentially or simultaneously administering to the patient a recombinant apyrase protein comprising the amino acid sequence of SEQ ID NO: 2 and ticagrelor, wherein the ischemic event is ST-segment elevation myocardial infarction (STEMI).

2 . The method according to claim 1 , wherein the method comprises

administering the recombinant apyrase protein to the patient, followed by the sequential administration of ticagrelor; or

administering ticagrelor to the patient, followed by the sequential administration of the recombinant apyrase protein.

3 . The method according to claim 1 , wherein the recombinant apyrase protein is administered to the patient within 24 hours or within 12 hours of ticagrelor the being administered to the patient.

4 . The method according to claim 1 , wherein the method further comprises at least daily administrations of ticagrelor to the patient starting at least 24 hours after the recombinant apyrase protein and ticagrelor are administered to the patient.

5 . The method according to claim 1 , wherein the recombinant apyrase protein is administered at a dose of 10 mg to 1000 mg.

6 . The method according to claim 1 , wherein:

ticagrelor is administered at a dose of between 60 to 200 mg.

7 . The method according to claim 1 , wherein the method further comprises administering aspirin to the patient.

8 . The method according to claim 1 , wherein the recombinant apyrase protein is sequentially or simultaneously administered to the patient in with ticagrelor 24 hours or less, 12 hours or less, or 6 hours or less after onset of the ischemic event.

9 . The method according to claim 6 , wherein ticagrelor is administered at a dose of 180 mg.

10 . The method according to claim 7 , wherein the aspirin is administered at a dose of 50 mg to 325 mg.