tTG-DGP biomarkers for monitoring celiac disease
The present disclosure relates generally to biomarkers and peptide arrays, and, more particularly, to a method of using a peptide array to identify biomarkers for an autoimmune disease such as, e.g., Celiac disease. Furthermore, a set of novel biomarkers for Celiac disease, having high sensitivity and specificity, are disclosed in addition to method of treatment using the novel biomarkers.
1 . An array comprising an array surface and at least two linear peptide probes, wherein each of the at least two linear peptide probes comprises a binding motif selected from the group consisting of SEQ ID NOS: 1-172, and wherein the at least two peptide probes extend from the array surface.
2 . The array of claim 1 , wherein the array surface is a solid surface or a microparticle.
3 . The array of claim 1 , wherein the at least two peptide probes further comprise a label.
4 . A peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOS: 1-172.
5 . The array of claim 1 , wherein each of the at least two linear peptide probes comprises a binding motif selected from the group consisting of SEQ ID NOS: 1-119 and 121-172.
6 . The peptide of claim 4 , consisting of an amino acid sequence selected from the group consisting of SEQ ID NOS: 1-119 and 121-172.