Noninvasive determination of resting state diastole hemodynamic information

1 . A method for providing hemodynamic information respective of a patient, the method comprising:

obtaining a three-dimensional electronic model of a coronary artery of the patient;

obtaining a boundary condition model value set that is specific to a midpoint of a diastole period of the patient's cardiac cycle at a resting state of the patient, wherein the boundary condition model value set comprises at least one inflow rate at a boundary of the three-dimensional model and at least one outflow rate at a boundary of the three-dimensional model;

performing a three-dimensional computational fluid dynamics (CFD) simulation of the coronary artery model based on the boundary condition model;

calculating, according to the CFD simulation, a pressure drop between a first location of the coronary artery and a second location of the coronary artery; and

determining, based on the calculated pressure drop and based on a reference pressure, a hemodynamic index value indicative of the presence of a lesion at the location.

2 . The method of claim 1 , further comprising:

creating the electronic model of the coronary artery.

3 . The method of claim 2 , further comprising:

receiving image data respective of the coronary artery; and

creating the electronic model based on the received image data.

4 . The method of claim 1 , wherein the boundary condition model value set comprises:

an inlet flow rate at an inlet of the coronary artery that is representative of a resting state of the patient; and

two or more outlet flow rates calculated according to the inlet flow rate and a flow splitting model.

5 . The method of claim 4 , further comprising:

determining the flow splitting model according to a geometry of the three dimensional model of the coronary artery; and

calculating the two or more outlet flow rates according to the inlet flow rate and the flow splitting model.

6 . A system for providing hemodynamic information respective of a patient, the system comprising:

a non-transitory, computer-readable memory storing instructions; and

a processor configured to execute the instructions to:

obtain a three-dimensional electronic model of a coronary artery of the patient;

obtain a boundary condition model value set that is specific to a midpoint of a diastole period of the patient's cardiac cycle at a resting state of the patient, wherein the boundary condition model value set comprises at least one inflow rate at a boundary of the three-dimensional model and at least one outflow rate at a boundary of the three-dimensional model;

perform a three-dimensional computational fluid dynamics (CFD) simulation of the coronary artery model based on the boundary condition model;

calculate, according to the CFD simulation, a pressure drop between a first location of the coronary artery and a second location of the coronary artery; and

determine, based on the calculated pressure drop and based on a reference pressure, a hemodynamic index value indicative of the presence of a lesion at the location.

7 . The system of claim 6 , wherein the memory stores further instructions that, when executed by the processor, cause the processor to:

create the electronic model of the coronary artery.

8 . The system of claim 7 , wherein the memory stores further instructions that, when executed by the processor, cause the processor to:

receive image data respective of the coronary artery; and

create the electronic model based on the received image data.

9 . The system of claim 6 , wherein the boundary condition model value set comprises:

an inlet flow rate at an inlet of the coronary artery that is representative of a resting state of the patient; and

two or more outlet flow rates calculated according to the inlet flow rate and a flow splitting model.

10 . The system of claim 9 , wherein the memory stores further instructions that, when executed by the processor, cause the processor to:

determine the flow splitting model according to a geometry of the three dimensional model of the coronary artery; and

calculate the two or more outlet flow rates according to the inlet flow rate and the flow splitting model.

11 . A method for providing hemodynamic information respective of a patient, the method comprising:

obtaining a three-dimensional electronic model of an anatomical region of the patient;

obtaining a boundary condition model that is specific to a midpoint of a diastole period of the patient's cycle at a resting state of the patient, wherein the boundary condition model value set comprises at least one inflow rate at a boundary of the three-dimensional model and at least one outflow rate at a boundary of the three-dimensional model;

calculating, based on the three-dimensional model and the boundary condition model, at a first time point in a cardiac cycle of the patient, a first pressure drop across a portion of an anatomical region of a patient;

calculating, based on the three-dimensional model and the boundary condition model, at a second time point in a cardiac cycle of the patient that is different than the first time point, a second pressure drop across the anatomical region portion;

calculating, for a range of time points of the cardiac cycle of the patient, respective pressure drops across the region according to the first and second pressure drops; and

determining, based on the calculated pressure drops for the range of time points and based on a reference pressure, a hemodynamic index value indicative of the presence of a lesion at the location.

12 . The method of claim 11 , wherein:

the anatomical region is a blood vessel; and

the anatomical region portion extends from an inlet of the blood vessel to a location in the blood vessel.

13 . The method of claim 12 , wherein the anatomical region is a coronary artery.

14 . The method of claim 11 , further comprising:

receiving image data respective of the anatomical region of the patient; and

creating the electronic model based on the received image data.

15 . The method of claim 11 , further comprising:

generating a curve of pressure relative to flow rate based on the pressure drops across the region; and

integrating the plot line to calculate the hemodynamic index value.