Implant for vascular closure

1 . An implantable device for sealing an aperture in a wall of a body vessel, the implantable device comprising:

an external fixation to be disposed on the outside of the vessel wall;

a scaffold to be disposed on the inside of the vessel wall and interfacing with the external fixation, with at least a portion of the scaffold to be disposed through an aperture in the vessel wall, the scaffold comprising:

a base plate;

a neck extending externally at an angle from the base plate, the neck comprising at least one lumen disposed therethrough; and

at least two retaining tabs,

wherein the at least two retaining tabs are disposed circumferentially around an exterior of the scaffold neck and extend radially away from the scaffold neck, and

wherein the at least two retaining tabs interface with a collar of the external fixation, thereby causing the external fixation to be coupled to the scaffold,

wherein the external fixation further comprises a tab disposed at an angle from the collar, the tab comprising a protrusion;

a patch configured to be disposed on the inside of the vessel wall and sandwiched between the external fixation and the scaffold, with the patch capable of substantially covering the full area of the aperture, thereby sealing the aperture; and

a closure pin disposed within the scaffold neck for sealing the at least one lumen after a guidewire is removed from the guidewire lumen; the closure pin comprising:

a cylindrical body;

a tip disposed at the distal end of the cylindrical body that comprises at least one of an angled tip and a stepped tapered tip; and

a substantially cylindrical head disposed at the proximal end of the cylindrical body and comprising a rectangular cutout, the rectangular cutout interfacing with the protrusion on the external fixation,

wherein distally pushing the closure pin into the scaffold neck causes the closure pin to seal the at least one lumen.

2 . The device of claim 1 , wherein the external fixation comprises:

the collar;

a base ring;

an anterior rib connecting the collar and the base ring; and

a posterior post connecting the collar and the base ring.

3 . The device of claim 1 , wherein the scaffold comprises a threaded portion at the base of the neck, the threads of the threaded portion interacting with the opening of the patch to hold the patch against the upper surface of the base plate of the scaffold.

4 . The device of claim 1 , wherein the closure pin comprises at least one of a pair of first and second distally extending arms, a rupture portion, an offset bore, an angled pin, a slidable rod, and an L-shaped closure pin.

5 . The device of claim 1 , wherein the scaffold neck comprises at least one of an internal taper, a gradual tapered portion, a ramp portion, a sleeve portion, an angled surface, and a partial bore.

6 . The device of claim 1 , wherein the aperture is located in a blood vessel, and a longitudinal axis of the patch is to be aligned with a longitudinal axis of the blood vessel when the device is in a sealing position.

7 . The device of claim 1 , wherein a longitudinal dimension of the patch is within a range of about 6 to about 29 mm and a lateral dimension of the patch is within a range of about 4 mm to about 22 mm.

8 . The device of claim 1 , wherein an average thickness of the patch is within a range of 100 μm to 500 μm.

9 . The device of claim 1 , wherein the patch comprises:

a base layer having a thickness within a range of 190-220 μm; and

an electrospun layer having a thickness within a range of 20-80 μm,

wherein a total thickness of the patch is within a range of 210-300 μm.

10 . The device of claim 1 , wherein the patch comprises an opening disposed at the center of the patch, the scaffold neck passing through the opening in the patch.

11 . An implantable device for sealing an aperture in a wall of a body vessel, the implantable device comprising:

an external fixation to be disposed on the outside of the vessel wall when in a sealing position;

a scaffold to be disposed on the inside of the vessel wall when in a sealing position and interfacing with the external fixation, with at least a portion of the scaffold to be disposed through an aperture in the vessel wall, the scaffold comprising;

a base plate;

a neck extending externally at an angle from the base plate, the neck comprising at least one lumen disposed therethrough; and

at least two retaining tabs, each retaining tab comprising:

a first protrusion;

a notch;

a flat portion; and

a second protrusion,

wherein the first protrusion, the notch, the flat portion, and the second protrusion are arranged longitudinally within the retaining tab along an axial direction of the scaffold neck,

wherein the first protrusion and the second protrusion extend out radially from the surface of the scaffold neck,

wherein the first protrusion extends further radially outwardly than the second protrusion,

wherein the notch is disposed at a smaller radius than the second protrusion,

wherein the at least two retaining tabs are disposed circumferentially around an exterior of the scaffold neck and extend radially away from the scaffold neck, and

wherein the at least two retaining tabs interface with a collar of the external fixation, thereby causing the external fixation to be coupled to the scaffold; and

a patch to be disposed on the inside of the vessel wall and sandwiched between the external fixation and the scaffold when in a sealing position, with the patch capable of substantially covering the full area of the aperture, thereby sealing the aperture.