Embolization microcatheter for delivery of beads to peripheral vessels
An embolization microcatheter including an elongated main body and a distal section, the distal section comprising an off-setting portion and a winding portion, wherein the winding portion comprises about half a loop of a three-dimensional spiral, such that a longitudinal axis of the winding portion is offset and/or disposed at an acute angle relative to a longitudinal axis of the elongated main body, and wherein the off-setting portion is disposed at an angle of between about 60° and about 120° degrees relative to the longitudinal axis of the elongated main body.
1 . An embolization microcatheter comprising an elongated main body and a distal section, the distal section comprising an off-setting portion and a winding portion;
wherein the winding portion comprises about half a loop of a three-dimensional spiral, such that a longitudinal axis of the winding portion is offset and/or disposed at an acute angle relative to a longitudinal axis of the elongated main body;
wherein the off-setting portion is disposed at an angle of between about 60° and about 120° degrees relative to the longitudinal axis of the elongated main body, and wherein the winding portion is configured to maneuver the microcatheter longitudinally in a screw-like motion thereby preventing collapsing and/or vibrating and/or whipping of the distal section of the microcatheter, and
wherein the embolization microcatheter has an average peak tracking force of less than 0.4 N.
2 . The embolization microcatheter of claim 1 , wherein the off-setting portion is curved.
3 . The embolization microcatheter of claim 1 , wherein the longitudinal axis of the winding portion is offset by between about 0.5 mm and about 5 mm relative to the longitudinal axis of the elongated main body.
4 . The embolization microcatheter of claim 1 , wherein the acute angle, at which the longitudinal axis of the winding portion is disposed relative to the longitudinal axis of the elongated main body, is between about 10° and about 60°.
5 . The embolization microcatheter of claim 1 , wherein a length of the winding portion measures between about 5 mm and about 20 mm.
6 . The embolization microcatheter of claim 1 , wherein a ratio of the length of the winding portion to a radius or mean radius, defined by the half a loop, is between about 2 and about 20.
7 . The embolization microcatheter of claim 1 , wherein the three-dimensional spiral is right-handed.
8 . The embolization microcatheter of claim 1 , wherein the three-dimensional spiral is left-handed.
9 . The embolization microcatheter of claim 1 , wherein the three-dimensional spiral is a helix.
10 . The embolization microcatheter of claim 1 , wherein the distal section is pre-shaped.
11 . The embolization microcatheter of claim 1 , wherein the main body and the offsetting portion together define a non-planar curve.
12 . The embolization microcatheter of claim 1 , wherein the elongated main body further comprises a filter section comprising a plurality of side openings formed in a wall of the elongated main body.
13 . The embolization microcatheter of claim 12 , wherein the side openings are in the form of slits having a length between about 200 μm and about 800 μm and a width between about 25 μm and about 100 μm.
14 . The embolization microcatheter of claim 1 , comprising a wall comprising an inner layer, an outer layer, and a skeleton intercalated between the inner layer and the outer layer.
15 . The embolization microcatheter of claim 14 , wherein an outer layer section of the outer layer, on the distal section, is more flexible than an outer layer section of the outer layer, on the elongated main body.
16 . The embolization microcatheter of claim 1 , wherein the distal section is dimensioned such that, when inserted into a tortuous blood vessel, different portions of the distal section contact opposite sides of the tortuous blood vessel at different longitudinal positions of the tortuous blood vessel.
17 . The embolization microcatheter of claim 1 , configured for guide-wire free navigation.
18 . The embolization microcatheter of claim 1 , wherein the off-set portion is configured to minimize interference of a user's field of view by the winded portion.
19 . A method for producing an embolization microcatheter distal section that defines a non-planar curve, the method comprising:
providing a 3-dimensional mandrel comprising an off-setting portion and a winding portion, wherein the winding portion comprises about half a loop of a three-dimensional spiral, such that a longitudinal axis of the winding portion is offset and/or disposed at an acute angle relative to a longitudinal axis of the elongated main body; and
wherein the off-setting portion is disposed at an angle of between about 60° and about 120° degrees relative to the longitudinal axis of the elongated main body;
in a heat chamber forming the embolization microcatheter tube on the mandrel, thereby producing the embolization microcatheter having the shape of the mandrel.